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Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output

Schiemann, Julia; Puggioni, Paolo; Dacre, Joshua; Pelko, Miha; Domanski, Aleksander; van Rossum, Mark C.W.; Duguid, Ian

Authors

Julia Schiemann

Paolo Puggioni

Joshua Dacre

Miha Pelko

Aleksander Domanski

Mark C.W. van Rossum

Ian Duguid



Abstract

Neuronal activity in primary motor cortex (M1) correlates with behavioral state, but the cellular mechanisms underpinning behavioral state-dependent modulation of M1 output remain largely unresolved. Here, we performed in vivo patch-clamp recordings from layer 5B (L5B) pyramidal neurons in awake mice during quiet wakefulness and self-paced, voluntary movement. We show that L5B output neurons display bidirectional (i.e., enhanced or suppressed) firing rate changes during movement, mediated via two opposing subthreshold mechanisms: (1) a global decrease in membrane potential variability that reduced L5B firing rates (L5Bsuppressed neurons), and (2) a coincident noradrenaline-mediated increase in excitatory drive to a subpopulation of L5B neurons (L5Benhanced neurons) that elevated firing rates. Blocking noradrenergic receptors in forelimb M1 abolished the bidirectional modulation of M1 output during movement and selectively impaired contralateral forelimb motor coordination. Together, our results provide a mechanism for how noradrenergic neuromodulation and network-driven input changes bidirectionally modulate M1 output during motor behavior.

Journal Article Type Article
Publication Date May 26, 2015
Journal Cell Reports
Print ISSN 2211-1247
Electronic ISSN 2211-1247
Publisher Elsevier (Cell Press)
Peer Reviewed Peer Reviewed
Volume 11
Issue 8
APA6 Citation Schiemann, J., Puggioni, P., Dacre, J., Pelko, M., Domanski, A., van Rossum, M. C., & Duguid, I. (2015). Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output. Cell Reports, 11(8), https://doi.org/10.1016/j.celrep.2015.04.042
DOI https://doi.org/10.1016/j.celrep.2015.04.042
Publisher URL https://www.sciencedirect.com/science/article/pii/S221112471500443X?via%3Dihub
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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