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Outputs (43)

Extraction of synaptic input properties in vivo (2017)
Journal Article
Puggioni, P., Jelitai, M., Duguid, I., & van Rossum, M. C. (2017). Extraction of synaptic input properties in vivo. Neural Computation, 29(7), https://doi.org/10.1162/NECO_a_00975

Knowledge of synaptic input is crucial for understanding synaptic integration and ultimately neural function. However, in vivo, the rates at which synaptic inputs arrive are high, so that it is typically impossible to detect single events. We show he... Read More about Extraction of synaptic input properties in vivo.

Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions (2017)
Journal Article
Keck, T., Toyoizumi, T., Chen, L., Doiron, B., Feldman, D. E., Fox, K., Gerstner, W., Haydon, P. G., Hübener, M., Lee, H.-K., Lisman, J. E., Rose, T., Sengpiel, F., Stellwagen, D., Stryker, M. P., Turrigiano, G. G., & van Rossum, M. C. (2017). Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philosophical Transactions B: Biological Sciences, 372(1715), https://doi.org/10.1098/rstb.2016.0158

We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next p... Read More about Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.

Functional consequences of pre- and postsynaptic expression of synaptic plasticity (2017)
Journal Article
Costa, R. P., Mizusaki, B. E., Sjöström, P. J., & van Rossum, M. C. (2017). Functional consequences of pre- and postsynaptic expression of synaptic plasticity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372(1715), https://doi.org/10.1098/rstb.2016.0153

Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci... Read More about Functional consequences of pre- and postsynaptic expression of synaptic plasticity.

Flexible theta sequence compression mediated via phase precessing interneurons (2016)
Journal Article
Chadwick, A., van Rossum, M. C., & Nolan, M. F. (2016). Flexible theta sequence compression mediated via phase precessing interneurons. eLife, 5, Article e20349. https://doi.org/10.7554/eLife.20349

Encoding of behavioral episodes as spike sequences during hippocampal theta oscillations provides a neural substrate for computations on events extended across time and space. However, the mechanisms underlying the numerous and diverse experimentally... Read More about Flexible theta sequence compression mediated via phase precessing interneurons.

Functional consequences of pre- and postsynaptic expression of synaptic plasticity (2016)
Preprint / Working Paper
Costa, R. P., Mizusaki, B. E., Jesper Sjöström, P., & van Rossum, M. C. W. Functional consequences of pre- and postsynaptic expression of synaptic plasticity

Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci... Read More about Functional consequences of pre- and postsynaptic expression of synaptic plasticity.

Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning (2015)
Journal Article
Costa, R. P., Froemke, R. C., Sjöström, P. J., & van Rossum, M. C. (2015). Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. eLife, 4, 1-16. https://doi.org/10.7554/eLife.09457

Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and pos... Read More about Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning.

A unified account of tilt illusions, association fields, and contour detection based on Elastica (2015)
Journal Article
Keemink, S. W., & van Rossum, M. C. (2016). A unified account of tilt illusions, association fields, and contour detection based on Elastica. Vision Research, 126, https://doi.org/10.1016/j.visres.2015.05.021

As expressed in the Gestalt law of good continuation, human perception tends to associate stimuli that form smooth continuations. Contextual modulation in primary visual cortex, in the form of association fields, is believed to play an important role... Read More about A unified account of tilt illusions, association fields, and contour detection based on Elastica.

Stability of neuronal networks with homeostatic regulation (2015)
Journal Article
Harnack, D., Pelko, M., Chaillet, A., Chitour, Y., & van Rossum, M. C. (2015). Stability of neuronal networks with homeostatic regulation. PLoS Computational Biology, 11(7), Article e1004357. https://doi.org/10.1371/journal.pcbi.1004357

Neurons are equipped with homeostatic mechanisms that counteract long-term perturbations of their average activity and thereby keep neurons in a healthy and information-rich operating regime. While homeostasis is believed to be crucial for neural fun... Read More about Stability of neuronal networks with homeostatic regulation.