Functional consequences of pre- and postsynaptic expression of synaptic plasticity

Costa, Rui Ponte; Mizusaki, Beatriz E.P.; Sj�str�m, P. Jesper; van Rossum, Mark C.W.

Abstract

Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.

Citation

Costa, R. P., Mizusaki, B. E., Sjöström, P. J., & van Rossum, M. C. (2017). Functional consequences of pre- and postsynaptic expression of synaptic plasticity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372(1715), https://doi.org/10.1098/rstb.2016.0153

• Journal Article Type: Article
• Acceptance Date: Nov 2, 2016
• Publication Date: Jan 2, 2017
• Deposit Date: Feb 7, 2018
• Publicly Available Date: Feb 7, 2018
• Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• Print ISSN: 0080-4622
• Electronic ISSN: 1471-2970
• Publisher: The Royal Society
• Peer Reviewed: Peer Reviewed
• Volume: 372
• Issue: 1715
• DOI: https://doi.org/10.1098/rstb.2016.0153
• Keywords: synaptic plasticity, Hebbian plasticity, spike-timing-dependent plasticity, homoeostatic plasticity, long-term potentiation, synaptic release
• Public URL: https://nottingham-repository.worktribe.com/output/842311
• Publisher URL: http://rstb.royalsocietypublishing.org/content/372/1715/20160153