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Functional consequences of pre- and postsynaptic expression of synaptic plasticity

Costa, Rui Ponte; Mizusaki, Beatriz E.P.; Sjöström, P. Jesper; van Rossum, Mark C.W.

Authors

Rui Ponte Costa

Beatriz E.P. Mizusaki

P. Jesper Sjöström

Mark C.W. van Rossum



Abstract

Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.

Journal Article Type Article
Publication Date Jan 2, 2017
Journal Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Print ISSN 0080-4622
Electronic ISSN 1471-2970
Publisher Royal Society, The
Peer Reviewed Peer Reviewed
Volume 372
Issue 1715
APA6 Citation Costa, R. P., Mizusaki, B. E., Sjöström, P. J., & van Rossum, M. C. (2017). Functional consequences of pre- and postsynaptic expression of synaptic plasticity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372(1715), doi:10.1098/rstb.2016.0153
DOI https://doi.org/10.1098/rstb.2016.0153
Keywords synaptic plasticity, Hebbian plasticity, spike-timing-dependent plasticity, homoeostatic plasticity, long-term potentiation, synaptic release
Publisher URL http://rstb.royalsocietypublishing.org/content/372/1715/20160153
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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