Skip to main content

Research Repository

See what's under the surface

Advanced Search

Extraction of synaptic input properties in vivo

Puggioni, Paolo; Jelitai, Marta; Duguid, Ian; van Rossum, Mark C.W.

Authors

Paolo Puggioni

Marta Jelitai

Ian Duguid

Mark C.W. van Rossum



Abstract

Knowledge of synaptic input is crucial for understanding synaptic integration and ultimately neural function. However, in vivo, the rates at which synaptic inputs arrive are high, so that it is typically impossible to detect single events. We show here that it is nevertheless possible to extract the properties of the events and, in particular, to extract the event rate, the synaptic time constants, and the properties of the event size distribution from in vivo voltage-clamp recordings. Applied to cerebellar interneurons, our method reveals that the synaptic input rate increases from 600 Hz during rest to 1000 Hz during locomotion, while the amplitude and shape of the synaptic events are unaffected by this state change. This method thus complements existing methods to measure neural function in vivo.

Journal Article Type Article
Publication Date Jul 1, 2017
Journal Neural Computation
Print ISSN 0899-7667
Electronic ISSN 1530-888X
Publisher Massachusetts Institute of Technology Press
Peer Reviewed Peer Reviewed
Volume 29
Issue 7
APA6 Citation Puggioni, P., Jelitai, M., Duguid, I., & van Rossum, M. C. (2017). Extraction of synaptic input properties in vivo. Neural Computation, 29(7), doi:10.1162/NECO_a_00975
DOI https://doi.org/10.1162/NECO_a_00975
Publisher URL https://www.mitpressjournals.org/doi/abs/10.1162/NECO_a_00975
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

Files

ivinf_2016_v7.pdf (946 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations

;