Skip to main content

Research Repository

Advanced Search

Extraction of synaptic input properties in vivo

Puggioni, Paolo; Jelitai, Marta; Duguid, Ian; van Rossum, Mark C.W.

Authors

Paolo Puggioni

Marta Jelitai

Ian Duguid

Mark C.W. van Rossum



Abstract

Knowledge of synaptic input is crucial for understanding synaptic integration and ultimately neural function. However, in vivo, the rates at which synaptic inputs arrive are high, so that it is typically impossible to detect single events. We show here that it is nevertheless possible to extract the properties of the events and, in particular, to extract the event rate, the synaptic time constants, and the properties of the event size distribution from in vivo voltage-clamp recordings. Applied to cerebellar interneurons, our method reveals that the synaptic input rate increases from 600 Hz during rest to 1000 Hz during locomotion, while the amplitude and shape of the synaptic events are unaffected by this state change. This method thus complements existing methods to measure neural function in vivo.

Citation

Puggioni, P., Jelitai, M., Duguid, I., & van Rossum, M. C. (2017). Extraction of synaptic input properties in vivo. Neural Computation, 29(7), https://doi.org/10.1162/NECO_a_00975

Journal Article Type Article
Acceptance Date Feb 1, 2017
Online Publication Date Jun 23, 2017
Publication Date Jul 1, 2017
Deposit Date Feb 7, 2018
Publicly Available Date Mar 28, 2024
Journal Neural Computation
Print ISSN 0899-7667
Electronic ISSN 1530-888X
Publisher Massachusetts Institute of Technology Press
Peer Reviewed Peer Reviewed
Volume 29
Issue 7
DOI https://doi.org/10.1162/NECO_a_00975
Public URL https://nottingham-repository.worktribe.com/output/968046
Publisher URL https://www.mitpressjournals.org/doi/abs/10.1162/NECO_a_00975

Files





You might also like



Downloadable Citations