Skip to main content

Research Repository

Advanced Search

Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

Costa, Rui Ponte; Froemke, Robert C.; Sjöström, P. Jesper; van Rossum, Mark C.W.

Authors

Rui Ponte Costa

Robert C. Froemke

P. Jesper Sjöström

Mark C.W. van Rossum



Abstract

Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. Moreover, learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes.

Citation

Costa, R. P., Froemke, R. C., Sjöström, P. J., & van Rossum, M. C. (2015). Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. eLife, 4, 1-16. https://doi.org/10.7554/eLife.09457

Journal Article Type Article
Acceptance Date Aug 25, 2015
Online Publication Date Aug 26, 2015
Publication Date Aug 26, 2015
Deposit Date Feb 7, 2018
Publicly Available Date Feb 7, 2018
Journal eLife
Electronic ISSN 2050-084X
Publisher eLife Sciences Publications
Peer Reviewed Peer Reviewed
Volume 4
Article Number e09457
Pages 1-16
DOI https://doi.org/10.7554/eLife.09457
Public URL http://eprints.nottingham.ac.uk/id/eprint/49628
Publisher URL https://elifesciences.org/articles/09457
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files


rui_15_publ.pdf (1.1 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





You might also like



Downloadable Citations