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Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

Costa, Rui Ponte; Froemke, Robert C.; Sjöström, P. Jesper; van Rossum, Mark C.W.

Authors

Rui Ponte Costa

Robert C. Froemke

P. Jesper Sjöström

Mark C.W. van Rossum



Abstract

Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. Moreover, learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes.

Journal Article Type Article
Publication Date Aug 26, 2015
Journal eLife
Electronic ISSN 2050-084X
Publisher eLife Sciences Publications
Peer Reviewed Peer Reviewed
Volume 4
Article Number e09457
Pages 1-16
APA6 Citation Costa, R. P., Froemke, R. C., Sjöström, P. J., & van Rossum, M. C. (2015). Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. eLife, 4, 1-16. https://doi.org/10.7554/eLife.09457
DOI https://doi.org/10.7554/eLife.09457
Publisher URL https://elifesciences.org/articles/09457
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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