Outputs (128)

Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering (2020)
Journal Article
Amer, M. H., Alvarez-Paino, M., McLaren, J., Pappalardo, F., Trujillo, S., Wong, J. Q., …Rose, F. R. (2021). Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering. Biomaterials, 266, Article 120450. https://doi.org/10.1016/j.biomaterials.2020.120450

© 2020 The Authors Mesenchymal stem cells are the focus of intense research in bone development and regeneration. The potential of microparticles as modulating moieties of osteogenic response by utilizing their architectural features is demonstrated... Read More about Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering.

Assessing the impact of physicochemical parameters in the predictive capabilities of thermodynamics-based stoichiometric approaches under mesophilic and thermophilic conditions (2020)
Working Paper
Tomi-Andrino, C., Norman, R., Millat, T., Soucaille, P., Winzer, K., Barrett, D. A., …Kim, D. Assessing the impact of physicochemical parameters in the predictive capabilities of thermodynamics-based stoichiometric approaches under mesophilic and thermophilic conditions

Metabolic engineering in the post-genomic era is characterised by the development of new methods for metabolomics and fluxomics, supported by the integration of genetic engineering tools and mathematical modelling. Particularly, constraint-based stoi... Read More about Assessing the impact of physicochemical parameters in the predictive capabilities of thermodynamics-based stoichiometric approaches under mesophilic and thermophilic conditions.

Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use? (2020)
Journal Article
Mody, S., Kirkdale, C. L., Thornley, T., Dickinson, A., Avery, A. J., Knaggs, R., …Bastable, R. (2020). Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use?. Pharmacy, 8(4), Article 185. https://doi.org/10.3390/pharmacy8040185

The misuse of opioids, including codeine which is sold over-the-counter (OTC) in United Kingdom (UK) community pharmacies, is a growing public health concern. An educational Patient Safety Card was developed and piloted to see if it nudged customers... Read More about Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use?.

An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients (2020)
Journal Article
Levy, N., Quinlan, J., El‐Boghdadly, K., Fawcett, W. J., Agarwal, V., Bastable, R. B., …Macintyre, P. E. (2020). An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients. Anaesthesia, 76(4), 520-536. https://doi.org/10.1111/anae.15262

This international multidisciplinary consensus statement was developed to provide balanced guidance on the safe peri‐operative use of opioids in adults. An international panel of healthcare professionals evaluated the literature relating to postopera... Read More about An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients.

Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma (2020)
Journal Article
Almasmoum, H., Airhihen, B., Seedhouse, C., & Winkler, G. S. (2020). Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma. Leukemia & Lymphoma, 62(2), 281-290. https://doi.org/10.1080/10428194.2020.1827243

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Mutations in the highly similar genes B-cell translocation gene 1 (BTG1) and BTG2 are identified in approximately 10–15% of non-Hodgkin lymphoma cases, which may suggest a direct involve... Read More about Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma.

All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2 (2020)
Journal Article
Xue, X., Ball, J. K., Alexander, C., & Alexander, M. R. (2020). All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2. Matter, 3(5), 1433-1441. https://doi.org/10.1016/j.matt.2020.10.006

© 2020 Elsevier Inc. The world faces a severe and acute public health emergency due to the ongoing coronavirus disease 2019 (COVID-19) global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Healthcare workers are... Read More about All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2.

Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function (2020)
Journal Article
Quijano, L. M., Naranjo, J. D., El-Mossier, S. O., Turner, N. J., Pineda Molina, C., Bartolacci, J., …Badylak, S. F. (2020). Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function. Tissue Engineering Part C Methods, 26(10), 528-540. https://doi.org/10.1089/ten.tec.2020.0243

Identification of matrix-bound nanovesicles (MBV) as ubiquitous components of the extracellular matrix (ECM) raises questions regarding their biologic functions and their potential theranostic application. Unlike liquid-phase extracellular vesicles (... Read More about Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function.

Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects (2020)
Journal Article
Woolley, V. C., Teakle, G. R., Prince, G., de Moor, C. H., & Chandler, D. (2020). Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects. Journal of Invertebrate Pathology, 177, Article 107480. https://doi.org/10.1016/j.jip.2020.107480

Hypocrealean entomopathogenic fungi (EPF) (Sordariomycetes, Ascomycota) are natural regulators of insect populations in terrestrial environments. Their obligately-killing life-cycle means that there is likely to be strong selection pressure for trait... Read More about Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects.

Predicting intestinal and hepatic first-pass metabolism of orally administered testosterone 3 undecanoate 4 (2020)
Journal Article
Zgair, A., Dawood, Y., Ibrahim, S. M., Back, H., Kagan, L., Gershkovich, P., & Lee, J. B. (2020). Predicting intestinal and hepatic first-pass metabolism of orally administered testosterone 3 undecanoate 4. Applied Sciences, 10(20), Article 7283. https://doi.org/10.3390/app10207283

The bioavailability of orally administered drugs could be impacted by intestinal and 12 hepatic first-pass metabolism. Testosterone undecanoate (TU), an orally administered ester prodrug 13 of testosterone, is significantly subjected to first-pass me... Read More about Predicting intestinal and hepatic first-pass metabolism of orally administered testosterone 3 undecanoate 4.

Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer (2020)
Journal Article
Hedegaard, C. L., Redondo-Gómez, C., Tan, B. Y., Ng, K. W., Loessner, D., & Mata, A. (2020). Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer. Science Advances, 6(40), Article eabb3298. https://doi.org/10.1126/sciadv.abb3298

Bioengineered three-dimensional (3D) matrices expand our experimental repertoire to study tumor growth and progression in a biologically relevant, yet controlled, manner. Here, we used peptide amphiphiles (PAs) to coassemble with and organize extrace... Read More about Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer.