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Outputs (1367)

Co-developing frameworks towards environmentally directed pharmaceutical prescribing in Scotland -A mixed methods study (2024)
Journal Article
Niemi, L., Arakawa, N., Glendell, M., Gagkas, Z., Gibb, S., Anderson, C., & Pfleger, S. (2024). Co-developing frameworks towards environmentally directed pharmaceutical prescribing in Scotland -A mixed methods study. Science of the Total Environment, 955, Article 176929. https://doi.org/10.1016/j.scitotenv.2024.176929

The presence of human pharmaceuticals in the aquatic environment is recognised internationally as an important public health and environmental issue. In Scotland, healthcare sustainability targets call for improvements to medicine prescribing and use... Read More about Co-developing frameworks towards environmentally directed pharmaceutical prescribing in Scotland -A mixed methods study.

Delivery of imiquimod to intestinal lymph nodes following oral administration (2024)
Journal Article
Chen, H., Ji, L., Wong, A., Chu, Y., Feng, W., Zhu, Y., Wang, J., Comeo, E., Kim, D.-H., Stocks, M. J., & Gershkovich, P. (in press). Delivery of imiquimod to intestinal lymph nodes following oral administration. International Journal of Pharmaceutics,

Intestinal lymph nodes are involved in the progression of colorectal cancer (CRC). Tumours suppress the activation of dendritic cells (DCs) in draining lymph nodes, diminishing anti-cancer immune response. Imiquimod (IMQ) facilitates DCs activation v... Read More about Delivery of imiquimod to intestinal lymph nodes following oral administration.

Cosmic‐Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station (2024)
Journal Article
Tran, Q. D., Spooner, N., Geoghehan, S., Thavarajah, S. R., Rahman, S., Tran, N. N., Williams, P. M., Jarquin, S. M., Kim, D., Davey, K., Buell, J., Shumbera, M., Gittleman, M., Clements, T., Stoudemire, J., Fisk, I., & Hessel, V. (2024). Cosmic‐Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station. Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202402361

In extreme environments people will have different needs for medicine(s), making it crucial to understand how such environments affect drug efficacy. Ibuprofen, commonly used in tablet formulation on Earth, could fail in space despite standard pharma... Read More about Cosmic‐Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station.

Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma (2024)
Journal Article
Serra, R., Smith, S. J., Rowlinson, J., Gorelick, N., Moloney, C., McCrorie, P., Veal, G. J., Berry, P., Chalmers, A. J., Suk, I., Shakesheff, K. M., Alexander, C., Grundy, R. G., Brem, H., Tyler, B. M., & Rahman, R. (2024). Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma. British Journal of Cancer, https://doi.org/10.1038/s41416-024-02878-2

Background: There is increased pan-cancer specific interest in repurposing the poly adenosine diphosphate-ribose polymerase-1 (PARP-1) inhibitor, olaparib, for newly diagnosed or recurrent isocitrate dehydrogenase wild type glioblastoma. We explore w... Read More about Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma.

Highly porous polycaprolactone microspheres for skeletal repair promote a mature bone cell phenotype in vitro (2024)
Journal Article
Paterson, T. E., Owen, R., Sherborne, C., Bahmaee, H., Harding, A. L., Green, N. H., Reilly, G. C., & Claeyssens, F. (2024). Highly porous polycaprolactone microspheres for skeletal repair promote a mature bone cell phenotype in vitro. Journal of Materials Chemistry B, https://doi.org/10.1039/d4tb01532k

Improving our ability to treat skeletal defects is a critical medical challenge that necessitates the development of new biomaterials. One promising approach involves the use of degradable polymer microparticles with an interconnected internal porosi... Read More about Highly porous polycaprolactone microspheres for skeletal repair promote a mature bone cell phenotype in vitro.

Disassembly of self-assembling peptide hydrogels as a versatile method for cell extraction and manipulation (2024)
Journal Article
Ligorio, C., Martinez-Espuga, M., Laurenza, D., Hartley, A., Rodgers, C. B., Kotowska, A. M., Scurr, D. J., Dalby, M. J., Ordóñez-Morán, P., & Mata, A. (2024). Disassembly of self-assembling peptide hydrogels as a versatile method for cell extraction and manipulation. Journal of Materials Chemistry B, https://doi.org/10.1039/D4TB01575D

Self-assembling peptide hydrogels (SAPHs) are increasingly being used as two-dimensional (2D) cell culture substrates and three-dimensional (3D) matrices due to their tunable properties and biomimicry of native tissues. Despite these advantages, SAPH... Read More about Disassembly of self-assembling peptide hydrogels as a versatile method for cell extraction and manipulation.

Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society (2024)
Journal Article
El-Boghdadly, K., Levy, N. A., Fawcett, W. J., Knaggs, R. D., Laycock, H., Baird, E., Cox, F. J., Eardley, W., Kemp, H., Malpus, Z., Partridge, A., Partridge, J., Patel, A., Price, C., Robinson, J., Russon, K., Walumbe, J., & Lobo, D. N. (2024). Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society. Anaesthesia, 79(11), 1220-1236. https://doi.org/10.1111/anae.16391

This is a consensus document produced by expert members of a Working Party established by the Association of Anaesthetists and the British Pain Society. It has been seen and approved by their Committee and Board respectively. It is supported by the E... Read More about Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society.

Single-step preparation of activated carbons from pine wood, olive stones and nutshells by KOH and microwaves: Influence of ultra-microporous for high CO2 capture (2024)
Journal Article
Duran-Jimenez, G., Rodriguez, J., Stevens, L., Altarawneh, S., Batchelor, A., Jiang, L., & Dodds, C. (2024). Single-step preparation of activated carbons from pine wood, olive stones and nutshells by KOH and microwaves: Influence of ultra-microporous for high CO2 capture. Chemical Engineering Journal, 499, Article 156135. https://doi.org/10.1016/j.cej.2024.156135

Biomass residues are crucial feedstocks for facing climate change challenges due to high-value products, such as producing activated carbons (AC) for carbon capture. Two stages of pyrolysis followed by activation at high temperatures are the most use... Read More about Single-step preparation of activated carbons from pine wood, olive stones and nutshells by KOH and microwaves: Influence of ultra-microporous for high CO2 capture.

Dietary supplementation of nucleotides and oligosaccharides in kittens reduces the expression of circulating miR13p, miR133a3p, miR2063p and miR3835p (2024)
Journal Article
Piccinini, A. M., Albanese, F., Harrison, M., Farquhar, M. J., Holcombe, L. J., Atwal, J., & Watson, P. (in press). Dietary supplementation of nucleotides and oligosaccharides in kittens reduces the expression of circulating miR13p, miR133a3p, miR2063p and miR3835p. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2024.1382436

Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation (2024)
Journal Article
Portelli, M., Ketelaar, M., Bates, S., Csomor, E., Shaw, D., Emsley, J., Brightling, C., Hall, I., Affleck, K., Edwards, M., Nawijn, M., Koppelman, G., Van Oosterhout, A., & Sayers, I. (2024). Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation. Clinical and Experimental Allergy, https://doi.org/10.1111/cea.14562

Introduction: The interleukin-33/interleukin-1 receptor-like-1 (IL-33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with IL1RL1 nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these variants'... Read More about Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation.