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The evidence for the effectiveness of safety alerts in electronic patient medication record systems at the point of pharmacy order entry: a systematic review (2013)
Journal Article
Ojeleye, O., Avery, A., Gupta, V., & Boyd, M. (2013). The evidence for the effectiveness of safety alerts in electronic patient medication record systems at the point of pharmacy order entry: a systematic review. BMC Medical Informatics and Decision Making, 13(July), Article 10. https://doi.org/10.1186/1472-6947-13-69

Background: Electronic Patient Medication Record (ePMR) systems have important safety features embedded to alert users about potential clinical hazards and errors. To date, there is no synthesis of evidence about the effectiveness of these safety fea... Read More about The evidence for the effectiveness of safety alerts in electronic patient medication record systems at the point of pharmacy order entry: a systematic review.

Specificity factors in cytoplasmic polyadenylation (2013)
Journal Article
Charlesworth, A., Meijer, H. A., & de Moor, C. H. (2013). Specificity factors in cytoplasmic polyadenylation. Wiley Interdisciplinary Reviews: RNA, 4(4), https://doi.org/10.1002/wrna.1171

Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been... Read More about Specificity factors in cytoplasmic polyadenylation.

Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1 (2013)
Journal Article
Hutter, V., Chau, D. Y., Hilgendorf, C., Brown, A., Cooper, A., Zann, V., …Bosquillon, C. (2014). Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 74-82. https://doi.org/10.1016/j.ejpb.2013.06.010

The impact of P-glycoprotein (MDR1, ABCB1) on drug disposition in the lungs as well as its presence and activity in in vitro respiratory drug absorption models remain controversial to date. Hence, we characterised MDR1 expression and the bidirectiona... Read More about Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1.

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor (2013)
Journal Article
Mistry, S. N., Valant, C., Sexton, P. M., Capuano, B., Christopoulos, A., & Scammells, P. J. (2013). Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. Journal of Medicinal Chemistry, 56(12), https://doi.org/10.1021/jm400540b

Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus. Adverse effects, due to indiscriminate... Read More about Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

Post-synthetic modification of conjugated microporous polymers (2013)
Journal Article
Ratvijitvech, T., Dawson, R., Laybourn, A., Khimyak, Y. Z., Adams, D. J., & Cooper, A. I. (2014). Post-synthetic modification of conjugated microporous polymers. Polymer, 55(1), 321-325. https://doi.org/10.1016/j.polymer.2013.06.004

Control over the surface functionality and microporosity in conjugated microporous polymers (CMPs) has been achieved by the post-synthetic modification of amines into amides of with different alkyl chains, one of which was chiral. The surface areas,... Read More about Post-synthetic modification of conjugated microporous polymers.

Delivery of definable number of drug or growth factor loaded poly(DL-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates (2013)
Journal Article
Qutachi, O., Shakesheff, K. M., & Buttery, L. D. (2013). Delivery of definable number of drug or growth factor loaded poly(DL-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates. Journal of Controlled Release, 168(1), https://doi.org/10.1016/j.jconrel.2013.02.029

Embryoid bodies (EBs) generated from embryonic stem cells are used to study processes of differentiation within a three dimensional (3D) cell environment. In many instances however, EBs are dispersed to single cell suspensions with a subsequent monol... Read More about Delivery of definable number of drug or growth factor loaded poly(DL-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates.

Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays (2013)
Journal Article
Hook, A. L., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D. G., …Alexander, M. R. (2013). Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials, 25(18), https://doi.org/10.1002/adma.201204936

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacteria... Read More about Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays.

Medicines use reviews: a potential resource or lost opportunity for general practice? (2013)
Journal Article
Latif, A., Pollock, K., & Boardman, H. F. (2013). Medicines use reviews: a potential resource or lost opportunity for general practice?. BMC Family Practice, 14, Article 57. https://doi.org/10.1186/1471-2296-14-57

Background: Patient non-adherence to medicines represents a significant waste of health resource and lost opportunity for health gain. Medicine management services are a key health policy strategy to encourage patients to take medicines as they are p... Read More about Medicines use reviews: a potential resource or lost opportunity for general practice?.

Synthesis and in vitro and in vivo characterization of highly ?1-Selective ?-Adrenoceptor partial agonists (2013)
Journal Article
Mistry, S. N., Baker, J. G., Fischer, P. M., Hill, S. J., Gardiner, S. M., & Kellam, B. (2013). Synthesis and in vitro and in vivo characterization of highly ?1-Selective ?-Adrenoceptor partial agonists. Journal of Medicinal Chemistry, 56(10), https://doi.org/10.1021/jm400348g

β-Adrenoceptor antagonists boast a 50-year use for symptomatic control in numerous cardiovascular diseases. One might expect highly selective antagonists are available for the human β-adrenoceptor subtype involved in these diseases, yet few truly β1-... Read More about Synthesis and in vitro and in vivo characterization of highly ?1-Selective ?-Adrenoceptor partial agonists.