Outputs (141)

Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities (2014)
Journal Article
Hedgecock, J., Standen, P. J., Beer, C., & Brown, D. (2014). Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities. Journal of Assistive Technologies, 8(3), 111-123. https://doi.org/10.1108/JAT-02-2014-0006

Purpose The purpose of this paper is to identify ways teachers might employ a robot to achieve learning objectives with pupils with intellectual disabilities and potential outcome measures. Design/methodology/approach A series of five case studi... Read More about Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities.

A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients (2014)
Journal Article
Rockliff, H. E., Lightman, S., Rhidian, E., Buchanan, H., Gordon, U., & Vedhara, K. (2014). A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients. Human Reproduction Update, 20(4), https://doi.org/10.1093/humupd/dmu010

BACKGROUND IVF treatment is usually stressful for patients, but individual differences in emotional response do exist. Differences in the stress response may be related to reproductive outcomes as well as to the development of psychiatric problems... Read More about A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients.

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization (2014)
Journal Article
Hill, S. J., May, L. T., Kellam, B., & Woolard, J. (2014). Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization. British Journal of Pharmacology, 171(5), https://doi.org/10.1111/bph.12345

Keywords:adenosine;allosterism;receptor;GPCR;dimerization;biased signalling The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It is released under a variety of physiological and pathophysiological condition... Read More about Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization.

The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study (2014)
Journal Article
Sneller, J., Buchanan, H., & Parekh, S. (2014). The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study. International Journal of Paediatric Dentistry, 24(6), https://doi.org/10.1111/ipd.12086

BACKGROUND: Amelogenesis imperfecta (AI) is a rare inherited dental defect where enamel does not form properly on the teeth. Research has shown that adolescents with AI may experience adverse psychosocial effects; however the impact on parents has n... Read More about The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study.

Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases (2014)
Journal Article
Muñoz-Lobato, F., Rodríguez-Palero, M. J., Naranjo-Galindo, F. J., Shephard, F., Gaffney, C. J., Szewczyk, N. J., …Miranda-Vizuete, A. (2014). Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases. Antioxidants and Redox Signaling, 20(2), 217-235. https://doi.org/10.1089/ars.2012.5051

Aims: Cells have developed quality control systems for protection against proteotoxicity. Misfolded and aggregation-prone proteins, which are behind the initiation and progression of many neurodegenerative diseases (ND), are known to challenge the pr... Read More about Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases.

Update on otitis media – prevention and treatment (2014)
Journal Article
Qureishi, A., Lee, Y., Belfield, K., Birchall, J. P., & Daniel, M. (2014). Update on otitis media – prevention and treatment. Infection and Drug Resistance, 2014(7), https://doi.org/10.2147/IDR.S39637

Acute otitis media and otitis media with effusion are common childhood disorders, a source of significant morbidity, and a leading cause of antibiotic prescription in primary health care. Although effective treatments are available, some shortcomings... Read More about Update on otitis media – prevention and treatment.

Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1? (2013)
Journal Article
Williams, A., Smith, J. R., Allaway, D., Harris, P., Liddell, S., & Mobasheri, A. (2013). Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?. Arthritis Research and Therapy, 15(6), Article R223. https://doi.org/10.1186/ar4424

Introduction: Arthritic diseases are characterized by the degradation of collagenous and noncollagenous extracellular matrix (ECM) components in articular cartilage. The increased expression and activity of matrix metalloproteinases (MMPs) is partly... Read More about Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?.

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells (2013)
Journal Article
Sharquie, I. K., Al-Ghouleh, A., Fitton, P., Clark, M. R., Armour, K. L., Sewell, H. F., …Ghaemmaghami, A. M. (2013). An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells. BMC Immunology, 14(Decemb), Article 12. https://doi.org/10.1186/1471-2172-14-54

Background: Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the u... Read More about An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods (2013)
Journal Article
Charman, C., Venn, A., Ravenscroft, J., & Williams, H. (2013). Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods. British Journal of Dermatology, 169(6), https://doi.org/10.1111/bjd.12590

Background: The Patient-Oriented Eczema Measure (POEM) is a validated, patient-derived assessment measure for monitoring atopic eczema severity, although further information on how different POEM scores translate into disease severity categories is n... Read More about Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods.

Risk factors for wheezing in infants born in Cuba (2013)
Journal Article
Venero-Fernandez, S., Suarez-Medina, R., Mora-Faife, E., Garcia-Garcia, G., Valle-Infante, I., Gomez-Marrero, L., …Fogarty, A. W. (2013). Risk factors for wheezing in infants born in Cuba. QJM: An International Journal of Medicine, 106(11), https://doi.org/10.1093/qjmed/hct143

Background: Cuba is a unique country, and despite limited economic development, has an excellent health system. However, the prevalence of asthma symptoms in children in Havana, Cuba, is unusually high. Aim: As early life exposures are critical t... Read More about Risk factors for wheezing in infants born in Cuba.