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Outputs (141)

Oral ketamine vs placebo in patients with cancer-related neuropathic pain (2018)
Journal Article
Fallon, M. T., Wilcock, A., Kelly, C. A., Paul, J., Lewsley, L., Norrie, J., & Laird, B. J. A. (2018). Oral ketamine vs placebo in patients with cancer-related neuropathic pain. JAMA Oncology, 4(6), 870-872. https://doi.org/10.1001/jamaoncol.2018.0131

Ketamine hydrochloride is used as an adjuvant treatment for cancer-related neuropathic pain, but evidence of its effectiveness is limited.1 Findings of a large trial investigating the use of ketamine for general cancer pain were negative, but the pop... Read More about Oral ketamine vs placebo in patients with cancer-related neuropathic pain.

Characterisation of insulin analogues therapeutically available to patients (2018)
Journal Article
Adams, G. G., Meal, A., Morgan, P. S., Alzahrani, Q. E., Zobel, H., Lithgo, R., …Chayen, N. (2018). Characterisation of insulin analogues therapeutically available to patients. PLoS ONE, 13(3), Article e0195010. https://doi.org/10.1371/journal.pone.0195010

The structure and function of clinical dosage insulin and its analogues were assessed. This included ‘native insulins’ (human recombinant, bovine, porcine), ‘fast-acting analogues’ (aspart, glulisine, lispro) and ‘slow-acting analogues’ (glargine, de... Read More about Characterisation of insulin analogues therapeutically available to patients.

Hip precautions after hip operation (HippityHop): protocol for a before and after study evaluating hip precautions following total hip replacement (2018)
Journal Article
Lightfoot, C., Sehat, K., Drury, G., Brewin, C., Coole, C., & Drummond, A. E. (in press). Hip precautions after hip operation (HippityHop): protocol for a before and after study evaluating hip precautions following total hip replacement. British Journal of Occupational Therapy, https://doi.org/10.1177/0308022618757183

Introduction Hip precautions are routinely used despite inconclusive evidence that they reduce dislocations, and concern that they impede activities of daily living. HippityHop compares a change in practice locally from implementing routine hip prec... Read More about Hip precautions after hip operation (HippityHop): protocol for a before and after study evaluating hip precautions following total hip replacement.

Levels of depression in transgender people and its predictors: results of a large matched control study with transgender people accessing clinical services (2018)
Journal Article
Witcomb, G. L., Bouman, W. P., Claes, L., Brewin, N., Crawford, J. R., & Arcelus, J. (2018). Levels of depression in transgender people and its predictors: results of a large matched control study with transgender people accessing clinical services. Journal of Affective Disorders, 235, https://doi.org/10.1016/j.jad.2018.02.051

Background: Depression is a serious disorder which significantly impacts wellbeing and quality of life. Studies exploring mental wellbeing in the transgender population are mostly limited by small, non-homogenous samples and lack of matched controls.... Read More about Levels of depression in transgender people and its predictors: results of a large matched control study with transgender people accessing clinical services.

Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial (2018)
Journal Article
das Nair, R., Mhizha-Murira, J. R., Anderson, P., Carpenter, H., Clarke, S., Groves, S., …Lincoln, N. B. (2018). Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial. Clinical Rehabilitation, 32(6), 777-789. https://doi.org/10.1177/0269215518755426

Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: Multi-centre, mixed-methods feasibi... Read More about Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial.

Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease (2018)
Journal Article
Sargeant, J. A., Bawden, S., Aithal, G. P., Simpson, E. J., Macdonald, I. A., Turner, M. C., …King, J. A. (2018). Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease. European Journal of Applied Physiology, 118(4), 817-828. https://doi.org/10.1007/s00421-018-3818-y

Purpose: This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral... Read More about Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease.

Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune-mediated tumour cell death induced by NAC (2018)
Journal Article
Kaewkangsadan, V., Verma, C., Eremin, J. M., Cowley, G. P., Ilyas, M., & Eremin, O. (2018). Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune-mediated tumour cell death induced by NAC. BMC Cancer, 18, Article 123. https://doi.org/10.1186/s12885-018-4044-z

Background The tumour microenvironment consists of malignant cells, stroma and immune cells. In women with large and locally advanced breast cancers (LLABCs) undergoing neoadjuvant chemotherapy (NAC), tumour-infiltrating lymphocytes (TILs), variou... Read More about Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune-mediated tumour cell death induced by NAC.

Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility (2018)
Journal Article
Cooper, D. J., Scammell, B. E., Batt, M. E., & Palmer, D. (in press). Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility. BMC Medical Research Methodology, 18(1), https://doi.org/10.1186/s12874-017-0464-8

Background: The impracticalities and comparative expense of carrying out a clinical assessment is an obstacle in many large epidemiological studies. The purpose of this study was to develop and validate a series of electronic self-reported line drawi... Read More about Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility.

Therapeutic benefit for late, but not early, passage mesenchymal stem cells on pain behaviour in an animal model of osteoarthritis (2017)
Journal Article
Chapman, V., Markides, H., Sagar, D. R., Xu, L., Burston, J. J., Mapp, P., …El Haj, A. J. (2017). Therapeutic benefit for late, but not early, passage mesenchymal stem cells on pain behaviour in an animal model of osteoarthritis. Stem Cells International, 2017, https://doi.org/10.1155/2017/2905104

Background: Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi... Read More about Therapeutic benefit for late, but not early, passage mesenchymal stem cells on pain behaviour in an animal model of osteoarthritis.