Outputs (27)

Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses (2023)
Journal Article
Mohd Jaafar, F., Belhouchet, M., Monsion, B., Bell-Sakyi, L., Mertens, P. P. C., & Attoui, H. (2023). Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses. Viruses, 15(9), Article 1908. https://doi.org/10.3390/v15091908

Non-structural protein 4 (NS4) of insect-borne and tick-borne orbiviruses is encoded by genome segment 9, from a secondary open reading frame. Though a protein dispensable for bluetongue virus (BTV) replication, it has been shown to counter the inter... Read More about Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses.

Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells (2023)
Journal Article
Monsion, B., Mohd Jaafar, F., Mertens, P. P., & Attoui, H. (2023). Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells. Biomolecules, 13(6), Article 878. https://doi.org/10.3390/biom13060878

At least 12 serotypes of ‘atypical’ bluetongue virus (BTV-25 to BTV-36) have been identified to date. These atypical serotypes fail to infect/replicate in Culicoides-derived cell lines and/or adult Culicoides vectors and hence can no longer be transm... Read More about Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells.

Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype (2023)
Journal Article
Attoui, H., Mohd Jaafar, F., Monsion, B., Klonjkowski, B., Reid, E., Fay, P. C., Saunders, K., Lomonossoff, G., Haig, D., & Mertens, P. P. C. (2023). Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype. Pathogens, 12(4), Article 602. https://doi.org/10.3390/pathogens12040602

Bluetongue is an economically important disease of domesticated and wild ruminants caused by bluetongue virus (BTV). There are at least 36 different serotypes of BTV (the identity of which is determined by its outer-capsid protein VP2), most of which... Read More about Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype.

Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells (2023)
Journal Article
Mohd Jaafar, F., Monsion, B., Mertens, P. P., & Attoui, H. (2023). Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells. International Journal of Molecular Sciences, 24(7), Article 6845. https://doi.org/10.3390/ijms24076845

Bioinformatic analyses have predicted that orbiviruses encode an additional, small non-structural protein (NS5) from a secondary open reading frame on genome segment 10. However, this protein has not previously been detected in infected mammalian or... Read More about Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells.

Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search (2022)
Journal Article
Fairbanks, E. L., Brennan, M. L., Mertens, P. P. C., Tildesley, M. J., & Daly, J. M. (2022). Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search. Transboundary and Emerging Diseases, 69(4), e671-e681. https://doi.org/10.1111/tbed.14420

African horse sickness (AHS) is a vector-borne disease transmitted by Culicoides spp., endemic to sub-Saharan Africa. There have been many examples of historic and recent outbreaks in the Middle East, Asia and Europe. However, not much is known about... Read More about Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search.

Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model (2021)
Journal Article
Attoui, H., Monsion, B., Klonjkowski, B., Zientara, S., Mertens, P. P. C., & Mohd Jaafar, F. (2021). Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model. Viruses, 13(11), Article 2208. https://doi.org/10.3390/v13112208

Bluetongue virus serotypes 1 to 24 are transmitted primarily by infected Culicoides midges, in which they also replicate. However, “atypical” BTV serotypes (BTV‐25, ‐26, ‐27 and ‐28) have recently been identified that do not infect and replicate in a... Read More about Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model.

Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes (2021)
Journal Article
Fay, P. C., Mohd Jaafar, F., Batten, C., Attoui, H., Saunders, K., Lomonossoff, G. P., Reid, E., Horton, D., Maan, S., Haig, D., Daly, J. M., & Mertens, P. P. C. (2021). Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes. Viruses, 13(8), Article 1455. https://doi.org/10.3390/v13081455

Bluetongue (BT) is a severe and economically important disease of ruminants that is widely distributed around the world, caused by the bluetongue virus (BTV). More than 28 different BTV serotypes have been identified in serum neutralisation tests (SN... Read More about Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes.

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved (2021)
Journal Article
Mohd Jaafar, F., Monsion, B., Belhouchet, M., Mertens, P. P. C., & Attoui, H. (2021). Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved. Viruses, 13(8), Article 1437. https://doi.org/10.3390/v13081437

Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV, Hepacivirus), dengue virus (Flavivirus), African swine fever virus (Asfarviridae) and poliovirus (Picornaviridae). We assess the antiviral effect... Read More about Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved.

An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins (2021)
Journal Article
Guimerà Busquets, M., Pullinger, G. D., Darpel, K. E., Cooke, L., Armstrong, S., Simpson, J., Palmarini, M., Fragkoudis, R., & Mertens, P. P. C. (2021). An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins. Viruses, 13(5), Article 919. https://doi.org/10.3390/v13050919

Arboviruses such as bluetongue virus (BTV) replicate in arthropod vectors involved in their transmission between susceptible vertebrate-hosts. The “classical” BTV strains infect and replicate effectively in cells of their insect-vectors (Culicoides b... Read More about An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins.

Vector Transmission of Animal Viruses (2021)
Book Chapter
Attoui, H., Jaafar, F. M., Fragkoudis, R., & Mertens, P. P. (2021). Vector Transmission of Animal Viruses. In Encyclopedia of Virology (542-551). (Fourth edition). Elsevier. https://doi.org/10.1016/b978-0-12-814515-9.00135-1

Animal “arboviruses” include viruses that are transmitted between their vertebrate hosts by arthropod vectors. They replicate in both their haematophagous arthropod vectors and vertebrate hosts. Vectors become infected after feeding on infected hosts... Read More about Vector Transmission of Animal Viruses.