Outputs (1630)

Neuroinflammation and schizophrenia: The role of Toxoplasma gondii infection and astrocytic dysfunction (2025)
Journal Article
Everett, A., & Elsheikha, H. M. (2025). Neuroinflammation and schizophrenia: The role of Toxoplasma gondii infection and astrocytic dysfunction. Journal of Neuroimmunology, 403, Article 578588. https://doi.org/10.1016/j.jneuroim.2025.578588

Obligate intracellular pathogens such as the protozoan Toxoplasma gondii exploit host cell mechanisms to facilitate their survival and replication. While T. gondii can infect any nucleated mammalian cell, it exhibits a particular affinity for central... Read More about Neuroinflammation and schizophrenia: The role of Toxoplasma gondii infection and astrocytic dysfunction.

Cardiotoxicity of breast cancer drug treatments (2025)
Journal Article
Haque, M., Atallah, N., Patke, R., Harris, A. E., Woodcock, C. L., Varun, D., Thompson, R. L., Jackson-Oxley, J., Okui, C. H., Dean, A., Alsaleem, M., Rakha, E., Irshad, S., Davis, M. B., Jeyapalan, J. N., Mongan, N. P., & Rutland, C. S. (2025). Cardiotoxicity of breast cancer drug treatments. Translational Oncology, 55, Article 102352. https://doi.org/10.1016/j.tranon.2025.102352

Breast cancer (BC) is a leading cause of cancer-related mortality among women worldwide. BC is regarded as a systemic disease. Consequently, the majority of BC patients undergo systemic therapy to reduce the risk of distant metastasis (DM) and associ... Read More about Cardiotoxicity of breast cancer drug treatments.

Whole-Genome Sequencing Analysis Revealed High Genomic Variability, Recombination Events and Mobile Genetic Elements in Streptococcus uberis Strains Isolated from Bovine Mastitis in Colombian Dairy Herds (2025)
Journal Article
Rios Agudelo, P. A., Reyes Vélez, J., Olivera Angel, M., Blanchard, A. M., Cuesta Astroz, Y., Caraballo Guzmán, A., & Torres Lindarte, G. (in press). Whole-Genome Sequencing Analysis Revealed High Genomic Variability, Recombination Events and Mobile Genetic Elements in Streptococcus uberis Strains Isolated from Bovine Mastitis in Colombian Dairy Herds. Antibiotics, 14(3), Article 297. https://doi.org/10.3390/antibiotics14030297

Introduction: Streptococcus uberis is a poorly controlled cause of bovine intramammary infections and a common motivation for the use antibiotics in dairy farms worldwide. Therefore, studying the genomic characteristics of this pathogen is fundamenta... Read More about Whole-Genome Sequencing Analysis Revealed High Genomic Variability, Recombination Events and Mobile Genetic Elements in Streptococcus uberis Strains Isolated from Bovine Mastitis in Colombian Dairy Herds.

Programming of pluripotency and the germ line co-evolved from a Nanog ancestor (2025)
Journal Article
Crowley, D., Simpson, L., Chatfield, J., Forey, T., Allegrucci, C., Sang, F., Holmes, N., Genikhovich, G., Technau, U., Cunningham, D., Silva, E., Mullin, N., Dixon, J. E., Loose, M., Alberio, R., & Johnson, A. D. (2025). Programming of pluripotency and the germ line co-evolved from a Nanog ancestor. Cell Reports, 44(3), Article 115396. https://doi.org/10.1016/j.celrep.2025.115396

Francois Jacob proposed that evolutionary novelty arises through incremental tinkering with pre-existing genetic mechanisms. Vertebrate evolution was predicated on pluripotency—the ability of embryonic cells to form somatic germ-layers and primordial... Read More about Programming of pluripotency and the germ line co-evolved from a Nanog ancestor.

Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts (2025)
Journal Article
Fakae, L. B., Zhong, J., Chan, K. L. A., Mekapothula, S., Cave, G. W., Zhu, X.-Q., Stevenson, C. W., & Elsheikha, H. M. (2025). Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts. Acta Parasitologica, 70(2), Article 63. https://doi.org/10.1007/s11686-024-00941-9

Purpose Acanthamoeba castellanii is an important opportunistic human protozoal pathogen that can cause both skin, ocular and brain infections. Recent studies have established that brews and solvent extract (SE) of green tea (Camellia sinensis) can in... Read More about Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts.

Experiences of End-of-Life Decision-Making in Equine Veterinary and Charity Teams (2025)
Journal Article
Cameron, A., Geldard, M., Mair, T., England, G., Burford, J., Freeman, S., Pollock, K., & Wilson, E. (2025). Experiences of End-of-Life Decision-Making in Equine Veterinary and Charity Teams. Animals, 15(5), Article 678. https://doi.org/10.3390/ani15050678

Veterinary and charity teams are frequently involved in equine end-of-life decisions. These can cause ethical dilemmas and emotional burdens and complicate communication with owners. Semi-structured focus groups explored experiences of making decisio... Read More about Experiences of End-of-Life Decision-Making in Equine Veterinary and Charity Teams.

Prevalence, risk factors, and regional insights of bovine fasciolosis in China: A systematic review and meta-analysis (2025)
Journal Article
Lan, Z., Zhang, Y.-X., Zhang, A.-H., Wang, Y.-Y., Qiu, H.-Y., Gao, J.-F., Cheng, G.-F., Elsheikha, H., & Wang, C.-R. (2025). Prevalence, risk factors, and regional insights of bovine fasciolosis in China: A systematic review and meta-analysis. Acta Tropica, 263, Article 107570. https://doi.org/10.1016/j.actatropica.2025.107570

Fasciolosis, a significant zoonotic disease with considerable economic and public health implications, presents a serious challenge to both animal husbandry and human health. Despite numerous reports on bovine fasciolosis, a comprehensive understandi... Read More about Prevalence, risk factors, and regional insights of bovine fasciolosis in China: A systematic review and meta-analysis.

Genomic and phenotypic characterisation of Pseudomonas aeruginosa isolates from canine otitis externa reveals high-risk sequence types identical to those found in human nosocomial infections (2025)
Journal Article
Secker, B., Shaw, S., Hobley, L., & Atterbury, R. J. (2025). Genomic and phenotypic characterisation of Pseudomonas aeruginosa isolates from canine otitis externa reveals high-risk sequence types identical to those found in human nosocomial infections. Frontiers in Microbiology, 16, Article 1526843. https://doi.org/10.3389/fmicb.2025.1526843

Introduction:

Canine otitis externa (OE) is a frequently-diagnosed condition in veterinary practices worldwide. Pseudomonas aeruginosa is commonly associated with chronic and recalcitrant canine OE, but studies with detailed genomic and phenotypi... Read More about Genomic and phenotypic characterisation of Pseudomonas aeruginosa isolates from canine otitis externa reveals high-risk sequence types identical to those found in human nosocomial infections.

Protective efficacy of a bivalent equine influenza H3N8 virus-like particle vaccine in horses (2025)
Journal Article
O'Kennedy, M. M., Reedy, S. E., Abolnik, C., Khan, A., Smith, T., du Preez, I., Olajide, E., Daly, J., Cullinane, A., & Chambers, T. M. (2025). Protective efficacy of a bivalent equine influenza H3N8 virus-like particle vaccine in horses. Vaccine, 50, Article 126861. https://doi.org/10.1016/j.vaccine.2025.126861

Equine influenza (EI) is a highly contagious acute respiratory disease of wild and domesticated horses, donkeys, mules, and other Equidae. EI is caused by the Equine Influenza virus (EIV), is endemic in many countries and outbreaks still have a sever... Read More about Protective efficacy of a bivalent equine influenza H3N8 virus-like particle vaccine in horses.

Plasma and Urine Pharmacokinetics of Long-Acting Injectable Omeprazole Following Intramuscular Administrations to Healthy Thoroughbred Horses (2025)
Journal Article
Harding, C., Viljanto, M., Hincks, P., Habershon-Butcher, J., & Paine, S. W. (2025). Plasma and Urine Pharmacokinetics of Long-Acting Injectable Omeprazole Following Intramuscular Administrations to Healthy Thoroughbred Horses. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13494

Omeprazole is a gastric acid secretion inhibitor used as an effective anti-ulcer drug. Based on oral administration studies, its International Screening Limit (ISL) was established in plasma and urine at 1 ng/mL with a Detection Time (DT) of 48 h. A... Read More about Plasma and Urine Pharmacokinetics of Long-Acting Injectable Omeprazole Following Intramuscular Administrations to Healthy Thoroughbred Horses.