Outputs (1686)

In Silico–Based Investigation of the Immunogenicity and Biochemical Attributes of Toxoplasma gondii Apical Membrane Antigen 1 (TgAMA1) (2025)
Journal Article
Foroutan, M., Ghaffari, A. D., Ghaffarifar, F., Karimipour-Saryazdi, A., Birgani, A. A., Majidiani, H., Cortes, H., & Elsheikha, H. M. (2025). In Silico–Based Investigation of the Immunogenicity and Biochemical Attributes of Toxoplasma gondii Apical Membrane Antigen 1 (TgAMA1). Journal of Parasitology Research, https://doi.org/10.1155/japr/3514414

Background: Apical membrane antigen 1 (AMA1) is a highly conserved microneme protein in apicomplexan parasites. In this study, immunoinformatics tools and in silico protein structure prediction were used to characterize the structure, physicochemical... Read More about In Silico–Based Investigation of the Immunogenicity and Biochemical Attributes of Toxoplasma gondii Apical Membrane Antigen 1 (TgAMA1).

Environmental interference and declining male fertility (2025)
Journal Article
Lea, R. G. (2025). Environmental interference and declining male fertility. Reproduction, Fertility and Development, 37(7), Article RD25047. https://doi.org/10.1071/rd25047

Declining human male ‘fertility’ has been equated with a temporal decline in sperm counts, with reports collectively spanning the period between 1934 and 2018. Although sperm quality is impacted by adult male lifestyle choices, e.g. diet, stress and... Read More about Environmental interference and declining male fertility.

Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens (2025)
Journal Article
Hu, Z., Ai, H., Wang, Z., Huang, S., Sun, H., Xuan, X., Chen, M., Wang, J., Yan, W., Sun, J., Pu, J., Brooke, C. B., Chang, K.-C., Sun, Y., & Liu, J. (2025). Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens. npj Vaccines, 10(1), Article 67. https://doi.org/10.1038/s41541-025-01115-y

H9N2 avian influenza virus (AIV) is endemic in poultry worldwide and increasingly zoonotic. Despite the long-term widespread use of inactivated vaccines, H9N2 AIVs remain dominant in chicken flocks. We demonstrated that inactivated vaccines did not p... Read More about Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens.

Extracellular Vesicle-Derived microRNA Crosstalk Between Equine Chondrocytes and Synoviocytes—An In Vitro Approach (2025)
Journal Article
Castanheira, C. I. G. D., Anderson, J. R., Clarke, E. J., Hackl, M., James, V., Clegg, P. D., & Peffers, M. J. (2025). Extracellular Vesicle-Derived microRNA Crosstalk Between Equine Chondrocytes and Synoviocytes—An In Vitro Approach. International Journal of Molecular Sciences, 26(7), Article 3353. https://doi.org/10.3390/ijms26073353

This study describes a novel technique to analyze the extracellular vesicle (EV)-derived microRNA (miRNA) crosstalk between equine chondrocytes and synoviocytes. Donor cells (chon- drocytes, n=8; synoviocytes, n=9) were labelled with 5-ethynyl uridin... Read More about Extracellular Vesicle-Derived microRNA Crosstalk Between Equine Chondrocytes and Synoviocytes—An In Vitro Approach.

Future crop breeding needs to consider future soils (2025)
Journal Article
Raza, S., Pandey, B. K., Hawkesford, M. J., Griffiths, S., Bennett, M. J., & Mooney, S. J. (2025). Future crop breeding needs to consider future soils. Nature Plants, https://doi.org/10.1038/s41477-025-01977-z

Modern crop breeding and seed certification agencies ignore the known spatial heterogeneity of soils and develop cultivars to thrive in a ‘one-size-fits-all’ soil environment. Neglecting the evolving dynamics of soils substantially undermines the cap... Read More about Future crop breeding needs to consider future soils.

Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review (2025)
Journal Article
Kubale, V., Best, A., Mai, S., Smale, T., Alibhai, A., Perez, W., El-Gendy, S. A., Alsafy, M. A., Sturrock, C. J., & Rutland, C. S. (2025). Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review. Cells Tissues Organs, https://doi.org/10.1159/000544776

Introduction:

The cartilago cordis is a structure present within the cardiac skeleton of some, but not all, vertebrate species. This systematic review compared the presence, structure, and function of the cartilago cordis from published works cov... Read More about Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review.

Investigation of the genetic diversity of gut mycobiota of the wild and laboratory mice (2025)
Journal Article
Zhao, J.-X., Elsheikha, H. M., Shang, K.-M., Su, J.-W., Wei, Y.-J., Qin, Y., Zhao, Z.-Y., Ma, H., & Zhang, X.-X. (2025). Investigation of the genetic diversity of gut mycobiota of the wild and laboratory mice. Microbiology Spectrum, Article e02840-24. https://doi.org/10.1128/spectrum.02840-24

Mice are colonized by diverse gut fungi, known as the mycobiota, which have received much less attention than bacterial microbiota. Here, we studied the diversities and structures of cecal fungal communities in wild (Lasiopodomys brandtii, Apodemus a... Read More about Investigation of the genetic diversity of gut mycobiota of the wild and laboratory mice.

Progressive evolution of Streptococcus equi from Streptococcus equi subsp. zooepidemicus and adaption to equine hosts (2025)
Journal Article
Wilson, H. J., Dong, J., van Tonder, A. J., Ruis, C., Lefrancq, N., McGlennon, A., Bustos, C., Frosth, S., Léon, A., Blanchard, A. M., Holden, M., Waller, A. S., & Parkhill, J. (2025). Progressive evolution of Streptococcus equi from Streptococcus equi subsp. zooepidemicus and adaption to equine hosts. Microbial Genomics, 11(3), Article 001366. https://doi.org/10.1099/mgen.0.001366

Streptococcus equi subsp. equi causes the equine respiratory disease ‘strangles’, which is highly contagious, debilitating and costly to the equine industry. S. equi emerged from the ancestral Streptococcus equi subsp. zooepidemicus and continues to... Read More about Progressive evolution of Streptococcus equi from Streptococcus equi subsp. zooepidemicus and adaption to equine hosts.

Tuberculosis in found dead badgers at the edge of the expanding bovine tuberculosis epidemic (2025)
Journal Article
Powell, S. M., Dessi, N., Bennett, M., Wang, B., Robertson, A., Waller, E., Smith, G. C., & Delahay, R. J. (2025). Tuberculosis in found dead badgers at the edge of the expanding bovine tuberculosis epidemic. Scientific Reports, 15(1), Article 10547. https://doi.org/10.1038/s41598-025-86930-y

Bovine tuberculosis (bTB) is a major disease of cattle in the UK, placing a significant economic burden on the taxpayer. The causative agent, Mycobacterium bovis, has a wide host range, including the European badger (Meles meles). While badgers have... Read More about Tuberculosis in found dead badgers at the edge of the expanding bovine tuberculosis epidemic.

Neuroinflammation and schizophrenia: The role of Toxoplasma gondii infection and astrocytic dysfunction (2025)
Journal Article
Everett, A., & Elsheikha, H. M. (2025). Neuroinflammation and schizophrenia: The role of Toxoplasma gondii infection and astrocytic dysfunction. Journal of Neuroimmunology, 403, Article 578588. https://doi.org/10.1016/j.jneuroim.2025.578588

Obligate intracellular pathogens such as the protozoan Toxoplasma gondii exploit host cell mechanisms to facilitate their survival and replication. While T. gondii can infect any nucleated mammalian cell, it exhibits a particular affinity for central... Read More about Neuroinflammation and schizophrenia: The role of Toxoplasma gondii infection and astrocytic dysfunction.