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Outputs (21)

Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus (2024)
Journal Article
Barnes, M., Chakrabarti, L., & MacColl, A. D. C. (2024). Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus. PLoS ONE, 19(7), Article e0295485. https://doi.org/10.1371/journal.pone.0295485

The three-spined stickleback (Gasterosteus aculeatus) is a teleost fish and a model organism in evolutionary ecology, useful for both laboratory and natural experiments. It is especially valued for the substantial intraspecific variation in morpholog... Read More about Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus.

A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer (2023)
Journal Article
Ebanks, B., Kwiecinska, P., Moisoi, N., & Chakrabarti, L. (2023). A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer. PLoS ONE, 18(7), Article e0276147. https://doi.org/10.1371/journal.pone.0276147

High-resolution respirometry methods allow for the assessment of oxygen consumption by the electron transfer systems within cells, tissue samples, and isolated mitochondrial preparations. As mitochondrial integrity is compromised by the process of cr... Read More about A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer.

A Common Anaesthetic, MS-222, Alters Measurements Made Using High-Resolution Respirometry in the Three-Spined Stickleback (Gasterosteus aculeatus) (2023)
Journal Article
Barnes, M., Ebanks, B., MacColl, A., & Chakrabarti, L. (2023). A Common Anaesthetic, MS-222, Alters Measurements Made Using High-Resolution Respirometry in the Three-Spined Stickleback (Gasterosteus aculeatus). Fishes, 8(1), Article 42. https://doi.org/10.3390/fishes8010042

Submersion in the anaesthetic MS-222 is a well-established and effective method used during the euthanasia of fish, but the consequences of treatment with this anaesthetic for mitochondrial respiration are yet to be established. This is important to... Read More about A Common Anaesthetic, MS-222, Alters Measurements Made Using High-Resolution Respirometry in the Three-Spined Stickleback (Gasterosteus aculeatus).

The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity (2022)
Journal Article
Wallace, M. N., Zobay, O., Hardman, E., Thompson, Z., Dobbs, P., Chakrabarti, L., & Palmer, A. R. (2022). The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity. Frontiers in Neuroanatomy, 16, Article 1034264. https://doi.org/10.3389/fnana.2022.1034264

Minicolumns are thought to be a fundamental neural unit in the neocortex and their replication may have formed the basis of the rapid cortical expansion that occurred during primate evolution. We sought evidence of minicolumns in the primary visual c... Read More about The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.

Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases (2022)
Journal Article
Ebanks, B., & Chakrabarti, L. (2022). Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases. Frontiers in Molecular Biosciences, 9, Article 854321. https://doi.org/10.3389/fmolb.2022.854321

The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites. Since the structura... Read More about Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases.

Sox-positive cell population in the adult cerebellum increases upon tissue degeneration (2021)
Journal Article
Salih, S., Nizamudeen, Z. A., De Melo, N., Chakrabarti, L., & Sottile, V. (2022). Sox-positive cell population in the adult cerebellum increases upon tissue degeneration. Experimental Neurology, 348, Article 113950. https://doi.org/10.1016/j.expneurol.2021.113950

Adult neurogenesis is well-described in the subventricular and subgranular zones of the mammalian brain. Recent observations that resident glia express stem cell markers in some areas of the brain not traditionally associated with neurogenesis hint t... Read More about Sox-positive cell population in the adult cerebellum increases upon tissue degeneration.

Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain (2021)
Journal Article
Sargent, C., Ebanks, B., Hardy, I. C., Davies, T. G. E., Chakrabarti, L., & Stöger, R. (2021). Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain. Frontiers in Insect Science, 1, Article 765179. https://doi.org/10.3389/finsc.2021.765179

Mitochondria are intracellular organelles responsible for cellular respiration with one of their major roles in the production of energy in the form of ATP. Activities with increased energetic demand are especially dependent on efficient ATP producti... Read More about Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain.

Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex (2021)
Journal Article
Ebanks, B., Wang, Y., Katyal, G., Sargent, C., Ingram, T. L., Bowman, A., Moisoi, N., & Chakrabarti, L. (2021). Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. International Journal of Molecular Sciences, 22(21), Article 11606. https://doi.org/10.3390/ijms222111606

Ageing is a major risk factor for many of the most prevalent diseases, including neurode-generative diseases, cancer, and heart disease. As the global population continues to age, behavioural interventions that can promote healthy ageing will improve... Read More about Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex.

Sequence and structure comparison of ATP synthase F0 subunits 6 and 8 in notothenioid fish (2021)
Journal Article
Katyal, G., Ebanks, B., Lucassen, M., Papetti, C., & Chakrabarti, L. (2021). Sequence and structure comparison of ATP synthase F0 subunits 6 and 8 in notothenioid fish. PLoS ONE, 16(10), 1-18. https://doi.org/10.1371/journal.pone.0245822

Mitochondrial changes such as tight coupling of the mitochondria have facilitated sustained oxygen and respiratory activity in haemoglobin-less icefish of the Channichthyidae family. We aimed to characterise features in the sequence and structure of... Read More about Sequence and structure comparison of ATP synthase F0 subunits 6 and 8 in notothenioid fish.