Outputs (105)

Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system (2015)
Journal Article
Kurlak, L., Williams, P. J., Bulmer, J. N., Broughton Pipkin, F., & Mistry, H. D. (2015). Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.011

Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiog... Read More about Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system.

Animals and anomalies: an analysis of the UK veterinary profession and the relative lack of state reform (2015)
Journal Article
Hobson-West, P., & Timmons, S. (2016). Animals and anomalies: an analysis of the UK veterinary profession and the relative lack of state reform. Sociological Review, 64(1), 47-63. https://doi.org/10.1111/1467-954X.12254

The sociology of professions literature would predict that the contemporary state would not allow groups to continue unregulated or unreformed. However, this is indeed the case with the UK veterinary profession, with legislation dating back to 1966.... Read More about Animals and anomalies: an analysis of the UK veterinary profession and the relative lack of state reform.

Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target (2015)
Journal Article
Mussai, F., Egan, S. A., Higginbotham-Jones, J., Perry, T., Beggs, A., Odintsova, E., …De Santo, C. (2015). Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target. Blood, 125(15), https://doi.org/10.1182/blood-2014-09-600643

Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation. We s... Read More about Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target.

IL-36α induces maturation of Th1-inducing human MDDC and synergises with IFN-γ to induce high surface expression of CD14 and CD11c (2015)
Journal Article
Higgins, J., Mutamba, S., Mahida, Y. R., Barrow, P., & Foster, N. (2015). IL-36α induces maturation of Th1-inducing human MDDC and synergises with IFN-γ to induce high surface expression of CD14 and CD11c. Human Immunology, 76(4), https://doi.org/10.1016/j.humimm.2015.01.012

We show that IL-36α induced maturation of human MDDCs and stimulated differentiation of IFN-γ producing (Type 1) CD3+ lymphocytes but was not as effective as IL-36β in doing so. For the first time, we also show that IL-36α induced expression of CD14... Read More about IL-36α induces maturation of Th1-inducing human MDDC and synergises with IFN-γ to induce high surface expression of CD14 and CD11c.

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses (2015)
Journal Article
Gao, H., Sun, Y., Hu, J., Qi, L., Wang, J., Xiong, X., …Liu, J. (in press). The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses. Scientific Reports, 5(1), https://doi.org/10.1038/srep08262

PA-X is a novel protein encoded by PA mRNA and is found to decrease the pathogenicity of pandemic 1918 H1N1 virus in mice. However, the importance of PA-X proteins in current epidemiologically important influenza A virus strains is not known. In this... Read More about The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses.

Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development (2015)
Journal Article
Russell, K., Emes, R. D., & Horrocks, P. (2015). Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development. Parasites and Vectors, 8(81), https://doi.org/10.1186/s13071-015-0701-0

Background: Over 2700 genes are subject to stage-specific regulation during the intraerythrocytic development of the human malaria parasite Plasmodium falciparum. Bioinformatic analyses have identified a large number of over-represented motifs in the... Read More about Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development.

Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding (2015)
Journal Article
Ware, S., Voigt, J.-P., & Langley-Evans, S. C. (2015). Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding. Journal of Nutritional Science, 4(e3), https://doi.org/10.1017/jns.2014.64

Fetal exposure to maternal undernutrition has lifelong consequences for physiological and metabolic function. Maternal low-protein diet is associated with an age-related phenotype in rats, characterised by a period of resistance to development of obe... Read More about Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding.

Area of hock hair loss in dairy cows : risk factors and correlation to a categorical scale (2015)
Journal Article
Lim, P., Huxley, J., Green, M. J., Othman, A., Potterton, S., Brignell, C., & Kaler, J. (2015). Area of hock hair loss in dairy cows : risk factors and correlation to a categorical scale. Veterinary Journal, 203(2), https://doi.org/10.1016/j.tvjl.2014.11.005

Data from 3691 dairy cows from 76 farms were used to investigate the risk factors associated with area of hair loss over the lateral aspect of the hock, and the correlation between the area of hair loss as calculated using a hock map and hock lesion... Read More about Area of hock hair loss in dairy cows : risk factors and correlation to a categorical scale.

Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring (2015)
Journal Article
Dellschaft, N. S., Alexandre-Gouabau, M.-C., Gardner, D. S., Antignac, J.-P., Keisler, D. H., Budge, H., …Sebert, S. P. (2015). Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring. Journal of Endocrinology, 224(2), https://doi.org/10.1530/JOE-14-0600

Maternal caloric restriction during late gestation reduces birth weight, but whether long-term adverse metabolic outcomes of intra-uterine growth retardation (IUGR) are dependent on either accelerated postnatal growth or exposure to an obesogenic env... Read More about Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring.

Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome (2015)
Journal Article
Monthoux, C., de Brot, S., Jackson, M., Bleul, U., & Walter, J. (2015). Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome. BMC Veterinary Research, 11(12), https://doi.org/10.1186/s12917-015-0318-8

BACKGROUND:

Skin malformations that resembled manifestations of Ehlers-Danlos-Syndrome were described in a variety of domestic animals during the last century as cutis hyperelastica, hyperelastosis cutis, dermatosparaxis, dermal/collagen dysplasia... Read More about Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome.