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Effect of osmotic stress on the expression of TRPV4 and BKCa channels and possible interaction with ERK1/2 and p38 in cultured equine chondrocytes (2014)
Journal Article
Hdud, I. M., Mobasheri, A., & Loughna, P. (2014). Effect of osmotic stress on the expression of TRPV4 and BKCa channels and possible interaction with ERK1/2 and p38 in cultured equine chondrocytes. American Journal of Physiology - Cell Physiology, 306(11), https://doi.org/10.1152/ajpcell.00287.2013

The metabolic activity of articular chondrocytes is influenced by osmotic alterations that occur in articular cartilage secondary to mechanical load. The mechanisms that sense and transduce mechanical signals from cell swelling and initiate volume re... Read More about Effect of osmotic stress on the expression of TRPV4 and BKCa channels and possible interaction with ERK1/2 and p38 in cultured equine chondrocytes.

Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana) (2014)
Journal Article
Nilsson, E. M., Fainberg, H. P., Choong, S. S., Giles, T. C., Sells, J., May, S., …Yon, L. (2014). Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana). PLoS ONE, 9(3), Article e91717. https://doi.org/10.1371/journal.pone.0091717

Adipose tissue (AT) is a dynamic and flexible organ with regulatory roles in physiological functions including metabolism, reproduction and inflammation; secreted adipokines, including leptin, and fatty acids facilitate many of these roles. The Afric... Read More about Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana).

Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins (2014)
Journal Article
Kurtz, S., Grau-Roma, L., Cortey, M., Fort, M., Rodríguez, F., Sibila, M., & Segalés, J. (2014). Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins. Veterinary Research, 45, Article 29. https://doi.org/10.1186/1297-9716-45-29

Porcine circovirus type 2 (PCV2) is the essential infectious agent for PCV2-systemic disease (PCV2-SD, formerly known as postweaning multisystemic wasting syndrome) and other pathological conditions. Recent studies indicated antigenic variability am... Read More about Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins.

Novel gonadal characteristics in an aged bovine freemartin (2014)
Journal Article
Remnant, J., Lea, R. G., Allen, C. E., Huxley, J., Robinson, R. S., & Brower, A. (2014). Novel gonadal characteristics in an aged bovine freemartin. Animal Reproduction Science, 146(1-2), https://doi.org/10.1016/j.anireprosci.2014.02.011

The gonads from a five year old freemartin Holstein animal were subjected to morphological analysis and to immunohistochemistry using antibodies against developmental and functional markers. We demonstrate, for the first time, the retention of anti-m... Read More about Novel gonadal characteristics in an aged bovine freemartin.

Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions (2014)
Journal Article

Toll-like receptors initiate inflammatory responses following the recognition of a wide repertoire of pathogens including bacteria, fungi, protozoa and viruses. They are composed of an extracellular leucine-rich repeat domain responsible for detectin... Read More about Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions.

Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action (2014)
Journal Article
Stocks, M., Alcaraz, L., Bailey, A., Bonnert, R., Cadogan, E., Christie, J., …Young, A. (2014). Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action. ACS Medicinal Chemistry Letters, 5(4), 416-421. https://doi.org/10.1021/ml4005232

A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and se... Read More about Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action.

Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects (2014)
Journal Article
Onoufriadis, A., Shoemark, A., Schmidts, M., Patel, M., Jimenez, G., Liu, H., …Mitchison, H. M. (2014). Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects. Human Molecular Genetics, 23(13), 3362-3374. https://doi.org/10.1093/hmg/ddu046

Primary ciliary dyskinesia (PCD) is an inherited chronic respiratory obstructive disease with randomized body laterality and infertility, resulting from cilia and sperm dysmotility. PCD is characterized by clinical variability and extensive genetic h... Read More about Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects.

Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines (2014)
Journal Article
Smith, C. M., Fry, S. C., Gough, K. C., Patel, A. J., Glenn, S., Goldrick, M., …Andrew, P. W. (2014). Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines. PLoS ONE, 9(2), Article e88144. https://doi.org/10.1371/journal.pone.0088144

Bacterial polysaccharides have numerous clinical or industrial uses. Recombinant plants could offer the possibility of producing bacterial polysaccharides on a large scale and free of contaminating bacterial toxins and antigens. We investigated the f... Read More about Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines.