Outputs (16)

Plasma and Urine Pharmacokinetics of Long-Acting Injectable Omeprazole Following Intramuscular Administrations to Healthy Thoroughbred Horses (2025)
Journal Article
Harding, C., Viljanto, M., Hincks, P., Habershon-Butcher, J., & Paine, S. W. (2025). Plasma and Urine Pharmacokinetics of Long-Acting Injectable Omeprazole Following Intramuscular Administrations to Healthy Thoroughbred Horses. Journal of Veterinary Pharmacology and Therapeutics, 48(3), 155-162. https://doi.org/10.1111/jvp.13494

Omeprazole is a gastric acid secretion inhibitor used as an effective anti-ulcer drug. Based on oral administration studies, its International Screening Limit (ISL) was established in plasma and urine at 1 ng/mL with a Detection Time (DT) of 48 h. A... Read More about Plasma and Urine Pharmacokinetics of Long-Acting Injectable Omeprazole Following Intramuscular Administrations to Healthy Thoroughbred Horses.

Pharmacokinetics of meloxicam for medication control in racing greyhounds (2023)
Presentation / Conference Contribution
Morris, T. H., Paine, S. W., Viljanto, M., Colgan, S. A., & Karamatic, S. L. (2023, September). Pharmacokinetics of meloxicam for medication control in racing greyhounds. Paper presented at 23rd International Conference of Racing Analysts and Veterinarians, Hong Kong, China

Recent published disciplinary findings from regulators of greyhound racing in Australia, Great Britain and Ireland have shown overall that the most common non-steroidal anti-inflammatory drug (NSAID) adverse analytical finding is for meloxicam. Whils... Read More about Pharmacokinetics of meloxicam for medication control in racing greyhounds.

Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5‐dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses (2023)
Journal Article
Paine, S. W., Harding, C., Waller, C. C., Zemenova, J., Viljanto, M., Habershon Butcher, J., & Hincks, P. R. (2023). Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5‐dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses. Journal of Veterinary Pharmacology and Therapeutics, 46(6), 365-374. https://doi.org/10.1111/jvp.13387

AbstractCalcium dobesilate (CD) is a synthetic venoactive drug used in veterinary medicine to treat equine navicular disease. Etamsylate is a haemostatic agent used in horses for the treatment of exercise‐induced pulmonary haemorrhage. Both etamsylat... Read More about Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5‐dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses.

Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes (2022)
Journal Article
White, K., Aldurdunji, M., Harris, J., Ortori, C., & Paine, S. (2022). Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes. Pharmacology Research and Perspectives, 10(6), Article e01031. https://doi.org/10.1002/prp2.1031

The translation of new injectable anaesthetic drugs from rodent to humans remains slow, despite the realisation that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the infl... Read More about Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.

Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration (2021)
Journal Article
Pesko, B., Habershon-Butcher, J., Muir, T., Gray, B., Taylor, P., Fenwick, S., Hincks, P., Scarth, J., & Paine, S. (2022). Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration. Journal of Veterinary Pharmacology and Therapeutics, 45(1), 54-62. https://doi.org/10.1111/jvp.13024

Paracetamol is a widely used, non-opioid analgesic and antipyretic drug. Scientific evidence suggests that it is an effective pain treatment in equine medicine. However, there is very little published information about the pharmacokinetics of the dru... Read More about Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration.

Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses (2021)
Journal Article
Paine, S. W., Aldurdunji, M., Garth-Greeves, A., Muir, T., & Hincks, P. R. (2022). Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. Journal of Veterinary Pharmacology and Therapeutics, 45(1), 46-53. https://doi.org/10.1111/jvp.13010

Hydroxyzine and cetirizine are first- and second-generation oral antihistamine drugs, respectively, used to treat allergic reactions in horses. Cetirizine is also a metabolite of hydroxyzine, which may lead to complexities in regulating their use in... Read More about Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses.

Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway (2020)
Journal Article
Burton, L., Scaife, P., Paine, S. W., Mellor, H. R., Abernethy, L., Littlewood, P., & Rauch, C. (2020). Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway. American Journal of Physiology - Cell Physiology, 318(5), C889-C902. https://doi.org/10.1152/ajpcell.00472.2019

Approximately 75% of xenobiotics are primarily eliminated through metabolism; thus the accurate scaling of metabolic clearance is vital to successful drug development. Yet, when data is scaled from in vitro to in vivo, hepatic metabolic clearance, th... Read More about Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway.

The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses (2020)
Journal Article
Paine, S. W., Bright, J., Scarth, J. P., Hincks, P. R., Pearce, C. M., Hannan, C., Machnik, M., & Hillyer, L. (2020). The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses. Journal of Veterinary Pharmacology and Therapeutics, 43(2), 162-170. https://doi.org/10.1111/jvp.12838

In equine and racing practice, detomidine and butorphanol are commonly used in combination for their sedative properties. The aim of the study was to produce detection times to better inform European veterinary surgeons, so that both drugs can be use... Read More about The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses.

Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs (2019)
Journal Article
Morris, T., Paine, S. W., Zahra, P., Li, E., Colgan, S., & Karamatic, S. (2019). Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs. Journal of Veterinary Pharmacology and Therapeutics, 42(5), 505-510. https://doi.org/10.1111/jvp.12775

© 2019 John Wiley & Sons Ltd Medication control in greyhound racing requires information from administration studies that measure drug levels in the urine as well as plasma, with time points that extend into the terminal phase of excretion. To char... Read More about Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs.

The pharmacokinetics of orally administered butylscopolamine in greyhound dogs (2018)
Journal Article
Morris, T., Paine, S. W., Viljanto, M., Hudson, S., Gower, S., Pittorino, M., & Colgan, S. (2018). The pharmacokinetics of orally administered butylscopolamine in greyhound dogs. Journal of Veterinary Pharmacology and Therapeutics, 41(6), 790-794. https://doi.org/10.1111/jvp.12701

The oral tablet formulation of butylscopolamine, which is available without prescription, is commonly used by trainers of racing greyhounds to treat functional urethral obstruction. As medication control of butylscopolamine is therefore required for... Read More about The pharmacokinetics of orally administered butylscopolamine in greyhound dogs.