The pharmacokinetics of orally administered butylscopolamine in greyhound dogs

Morris, Tim; Paine, Stuart W.; Viljanto, Marjaana; Hudson, Simon; Gower, Simon; Pittorino, Melissa; Colgan, Sally

Abstract

The oral tablet formulation of butylscopolamine, which is available without prescription, is commonly used by trainers of racing greyhounds to treat functional urethral obstruction. As medication control of butylscopolamine is therefore required for such use to ensure the integrity of greyhound racing an administration study was performed in six greyhounds to determine the pharmacokinetics of orally administered butylscopolamine. A single dose of one 10 mg butylscopolamine tablet was administered orally to simulate this use in greyhound racing. Blood, urine and faeces were collected at regular intervals from the greyhounds for up to 9 days and butylscopolamine concentrations determined. There was some, but very limited, absorption of butylscopolamine, with rapid elimination from plasma with a mean half-life of 2 hours. Urine concentrations initially declined in a similar manner to the plasma pharmacokinetics but then entered a much longer half-life of approximately 50 hours. Faecal concentrations declined to very low levels between 48 and 120 hours. The use of orally administered butylscopolamine for functional urethral obstruction in greyhounds is unjustified due this very limited drug absorption. Medication control of butylscopolamine’s anti-spasmodic effect on the digestive tract is possible by setting screening limits based on the urinary and faecal drug levels as determined in this study.

Citation

Morris, T., Paine, S. W., Viljanto, M., Hudson, S., Gower, S., Pittorino, M., & Colgan, S. (2018). The pharmacokinetics of orally administered butylscopolamine in greyhound dogs. Journal of Veterinary Pharmacology and Therapeutics, 41(6), 790-794. https://doi.org/10.1111/jvp.12701

• Journal Article Type: Article
• Acceptance Date: Jul 10, 2018
• Online Publication Date: Aug 3, 2018
• Publication Date: 2018-12
• Deposit Date: Oct 8, 2018
• Publicly Available Date: Aug 4, 2019
• Journal: Journal of Veterinary Pharmacology and Therapeutics
• Print ISSN: 0140-7783
• Electronic ISSN: 1365-2885
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 41
• Issue: 6
• Pages: 790-794
• DOI: https://doi.org/10.1111/jvp.12701
• Keywords: butylscopolamine; greyhound; pharmacokinetics; plasma
• Public URL: https://nottingham-repository.worktribe.com/output/1150925
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jvp.12701
• Additional Information: This is the peer reviewed version of the following article: The pharmacokinetics of orally administered butylscopolamine in greyhound dogs, Tim Morris, Stuart W. Paine, Marjaana Viljanto, Simon Hudson, Simon Gower, Melissa Pittorino, Sally Colgan, Journal of Veterinary Pharmacology and Therapeutics (2018), which has been published in final form at 10.1111/jvp.12701. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• Contract Date: Oct 8, 2018