Outputs (391)

Managing an impacted fetal head at caesarean section: a UK survey of healthcare professionals and parents (2022)
Journal Article
Hanley, S. J., Walker, K. F., Wakefield, N., Plachcinski, R., Pallotti, P., Tempest, N., Pillai, A., Thornton, J., Jones, N., & Mitchell, E. J. (2022). Managing an impacted fetal head at caesarean section: a UK survey of healthcare professionals and parents. European Journal of Obstetrics and Gynecology and Reproductive Biology, 271, 88-92. https://doi.org/10.1016/j.ejogrb.2022.01.033

Objective(s)
To understand current practice, expertise and training requirements for management of an impacted fetal head (IFH) at caesarean section (CS) in the UK, and whether a clinical trial of techniques to manage an IFH is acceptable.

Study... Read More about Managing an impacted fetal head at caesarean section: a UK survey of healthcare professionals and parents.

A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT (2022)
Journal Article
Daniels, J., Dixon, E. F., Gill, A., Bishop, J., D'Amico, M., Ahmed, K., Dodds, J., Tryposkiadis, K., Wilks, M., Millar, M., Husain, S., Gray, J., Whiley, A., Moore, P. V., Munetsi, R. L., Hemming, K., Roberts, T., Plumb, J., Deeks, J., Khan, K. S., & Thangaratinam, S. (2022). A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT. Health Technology Assessment, 26(12), 1-82. https://doi.org/10.3310/BICF1187

BACKGROUND: Mother-to-baby transmission of group B Streptococcus (Streptococcus agalactiae) is the main cause of early-onset infection. OBJECTIVES: We investigated if intrapartum antibiotic prophylaxis directed by a rapid intrapartum test reduces mat... Read More about A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT.

Less is more. Discovering the latent factors of trait resilience (2022)
Journal Article
Maltby, J., & Hall, S. S. (2022). Less is more. Discovering the latent factors of trait resilience. Journal of Research in Personality, 97, Article 104193. https://doi.org/10.1016/j.jrp.2022.104193

The current paper establishes the latent factors of many direct or proxy trait resilience assessments. Study 1 (n = 849) demonstrates four latent factors (recovery, sustainability, adaptability, and social cohesion) among 61 direct and proxy assessme... Read More about Less is more. Discovering the latent factors of trait resilience.

The FEED1 trial: protocol for a randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30–33 weeks gestational age) (2022)
Journal Article
Mitchell, E. J., Meakin, G., Anderson, J., Dorling, J., Gale, C., Haines, R., Kenyan, C., Johnson, M. J., McGuire, W., Mistry, H., Montgomery, A., Oddie, S., Ogollah, R., Pallotti, P., Partlett, C., Walker, K. F., & Ojha, S. (2022). The FEED1 trial: protocol for a randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30–33 weeks gestational age). Trials, 23(1), Article 64. https://doi.org/10.1186/s13063-021-05994-z

Background: In the UK, approximately 8% of live births are preterm (before 37 weeks gestation), more than 90% of whom are born between 30 and 36 weeks, forming the largest proportion of a neonatal units’ workload. Neonatologists are cautious in initi... Read More about The FEED1 trial: protocol for a randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30–33 weeks gestational age).

Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study (2022)
Journal Article
Daniels, J. P., Dixon, E., Gill, A., Bishop, J., Wilks, M., Millar, M., Gray, J., Roberts, T. E., Plumb, J., Deeks, J. J., Hemming, K., Khan, K. S., Thangaratinam, S., & Collaboative Group, G. (2022). Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study. BMC Medicine, 20, Article 9. https://doi.org/10.1186/s12916-021-02202-2

Background: Mother-to-baby transmission of group B Streptococcus (GBS) is the main cause of early-onset infection. We evaluated whether, in women with clinical risk factors for early neonatal infection, the use of point-of-care rapid intrapartum test... Read More about Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study.

Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze) (2022)
Journal Article
Maheshwari, A., Bell, J. L., Bhide, P., Brison, D., Child, T., Chong, H. Y., Cheong, Y., Cole, C., Coomarasamy, A., Cutting, R., Hardy, P., Hamoda, H., Khalaf, Y., Kurinczuk, J. J., Juszczak, E., Lavery, S., Linsell, L., Macklon, N., Mathur, R., Pundir, J., …Bhattacharya, S. (2022). Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze). Human Reproduction, 37(3), 476-487. https://doi.org/10.1093/humrep/deab279

STUDY QUESTION: Does a policy of elective freezing of embryos, followed by frozen embryo transfer result in a higher healthy baby rate, after first embryo transfer, when compared with the current policy of transferring fresh embryos? SUMMARY ANSWER:... Read More about Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze).

First‐trimester ultrasound detection of fetal heart anomalies: systematic review and meta‐analysis (2022)
Journal Article
Karim, J. N., Bradburn, E., Roberts, N., Papageorghiou, A. T., Alfirevic, Z., Chudleigh, T., Goodman, H., Ioannou, C., Longworth, H., Nicolaides, K. H., Pandya, P., Smith, G., Thilaganathan, B., Thornton, J., Rivero-Arias, O., Campbell, H., Juszczak, E., Linsell, L., Wilson, E., Hinton, L., …Yaz, G. (2022). First‐trimester ultrasound detection of fetal heart anomalies: systematic review and meta‐analysis. Ultrasound in Obstetrics and Gynaecology, 59(1), 11-25. https://doi.org/10.1002/uog.23740

Objectives: To determine the diagnostic accuracy of ultrasound at 11–14 weeks' gestation in the detection of fetal cardiac abnormalities and to evaluate factors that impact the detection rate. Methods: This was a systematic review of studies evaluati... Read More about First‐trimester ultrasound detection of fetal heart anomalies: systematic review and meta‐analysis.

Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences (2022)
Journal Article
Nomikos, P. A., Hall, M. C., Fuller, A., Ogollah, R., Valdes, A. M., Doherty, M., Walsh, D. A., das Nair, R., & Abhishek, A. (2022). Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences. PLoS ONE, 17(1), Article e0262422. https://doi.org/10.1371/journal.pone.0262422

Objectives The overall purpose of this research programme is to develop and test the feasibility of a complex intervention for knee pain delivered by a nurse, and comprising both non-pharmacological and pharmacological interventions. In this first ph... Read More about Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences.

Lactic acid gel versus metronidazole for recurrent bacterial vaginosis in women aged 16 years and over: the VITA RCT (2022)
Journal Article
Armstrong-Buisseret, L., Brittain, C., Kai, J., David, M., Anstey Watkins, J., Ozolins, M., Jackson, L., Abdali, Z., Hepburn, T., Griffiths, F., Montgomery, A., Daniels, J., Manley, A., Dean, G., & Ross, J. D. (2022). Lactic acid gel versus metronidazole for recurrent bacterial vaginosis in women aged 16 years and over: the VITA RCT. Health Technology Assessment, 26(2), 1-170. https://doi.org/10.3310/ZZKH4176

BACKGROUND: Bacterial vaginosis is a common and distressing condition associated with serious comorbidities. Antibiotic treatment is usually clinically effective in the short term, but recurrence is common and side effects can occur. OBJECTIVES: The... Read More about Lactic acid gel versus metronidazole for recurrent bacterial vaginosis in women aged 16 years and over: the VITA RCT.

Long-term Effectiveness of Adjuvant Treatment with Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared with Dopamine Agonists among Patients with Parkinson Disease Uncontrolled by Levodopa Therapy: The PD MED Randomized Clinical Trial (2021)
Journal Article
Gray, R., Patel, S., Ives, N., Rick, C., Woolley, R., Muzerengi, S., Gray, A., Jenkinson, C., McIntosh, E., Wheatley, K., Williams, A., & Clarke, C. E. (2022). Long-term Effectiveness of Adjuvant Treatment with Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared with Dopamine Agonists among Patients with Parkinson Disease Uncontrolled by Levodopa Therapy: The PD MED Randomized Clinical Trial. JAMA Neurology, 79(2), 131-140. https://doi.org/10.1001/jamaneurol.2021.4736

Importance: Many people with Parkinson disease (PD) develop motor complications that are uncontrolled by levodopa dose adjustment. Among these patients, it is uncertain which drug class is more effective as adjuvant therapy. Objective: To compare the... Read More about Long-term Effectiveness of Adjuvant Treatment with Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared with Dopamine Agonists among Patients with Parkinson Disease Uncontrolled by Levodopa Therapy: The PD MED Randomized Clinical Trial.