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Outputs (390)

Lifestyle matters for maintenance of health and wellbeing in people aged 65 years and over: study protocol for a randomised controlled trial (2013)
Journal Article
Sprange, K., Mountain, G. A., Brazier, J., Cook, S. P., Craig, C., Hind, D., Walters, S. J., Windle, G., Woods, R., Keetharuth, A. D., Chater, T., & Horner, K. (2013). Lifestyle matters for maintenance of health and wellbeing in people aged 65 years and over: study protocol for a randomised controlled trial. Trials, 14, Article 302. https://doi.org/10.1186/1745-6215-14-302

Background
Healthy, active ageing is strongly associated with good mental wellbeing which in turn helps to prevent mental illness. However, more investment has been made into research into interventions to prevent mental illness than into those desi... Read More about Lifestyle matters for maintenance of health and wellbeing in people aged 65 years and over: study protocol for a randomised controlled trial.

Parents' experiences and satisfaction with care during the birth of their very preterm baby: a qualitative study (2013)
Journal Article
Sawyer, A., Rabe, H., Abbott, J., Gyte, G., Duley, L., & Ayers, S. (2013). Parents' experiences and satisfaction with care during the birth of their very preterm baby: a qualitative study. BJOG: An International Journal of Obstetrics and Gynaecology, 120(5), 637-643. https://doi.org/10.1111/1471-0528.12104

Objective: To assess parents' experiences and satisfaction with care during very preterm birth and to identify domains associated with positive and negative experiences of care.

Design: Qualitative study using semi-structured interviews.

Settin... Read More about Parents' experiences and satisfaction with care during the birth of their very preterm baby: a qualitative study.

The addition of a goal-based motivational interview to treatment as usual to enhance engagement and reduce dropouts in a personality disorder treatment service: results of a feasibility study for a randomized controlled trial (2013)
Journal Article
McMurran, M., Cox, W. M., Whitham, D., & Hedges, L. (2013). The addition of a goal-based motivational interview to treatment as usual to enhance engagement and reduce dropouts in a personality disorder treatment service: results of a feasibility study for a randomized controlled trial. Trials, 14(1), Article 50. https://doi.org/10.1186/1745-6215-14-50

Background: There are high rates of treatment non-completion for personality disorder and those who do not complete treatment have poorer outcomes. A goal-based motivational interview may increase service users’ readiness to engage with therapy and s... Read More about The addition of a goal-based motivational interview to treatment as usual to enhance engagement and reduce dropouts in a personality disorder treatment service: results of a feasibility study for a randomized controlled trial.

Axillary treatment for patients with early breast cancer and lymph node metastasis: systematic review protocol (2013)
Journal Article
Goyal, A., Duley, L., & Fakis, A. (2013). Axillary treatment for patients with early breast cancer and lymph node metastasis: systematic review protocol. World Journal of Surgical Oncology, 11(6), Article 6. https://doi.org/10.1186/1477-7819-11-6

Background: For patients with early breast cancer and lymph node metastasis, axillary treatment is widely recommended. This is either surgical removal of the axillary lymph nodes, or axillary radiotherapy. The rationale for axillary treatment is that... Read More about Axillary treatment for patients with early breast cancer and lymph node metastasis: systematic review protocol.

Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial (2011)
Journal Article
Edmans, J., Conroy, S., Harwood, R., Lewis, S., Elliott, R. A., Logan, P., Bradshaw, L., Franklin, M., & Gladman, J. (2011). Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial. Trials, 12, Article 200. https://doi.org/10.1186/1745-6215-12-200

Background
Many older people presenting to Acute Medical Units (AMU) are discharged after only a short stay (< 72 hours), yet many re-present to hospital or die within 1 year. Comprehensive Geriatric Assessment may improve patient outcomes for this... Read More about Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial.

Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops? (2011)
Journal Article
Clarke, C. E., Patel, S., Ives, N., Rick, C., Wheatley, K., & Gray, R. (2011). Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?. Movement Disorders, 26(7), 1187-1193. https://doi.org/10.1002/mds.23519

Background:

Evidence from clinical trials with monoamine oxidase type B inhibitors (TEMPO, ADAGIO and DATATOP) and levodopa (ELLDOPA) suggests that Parkinson's disease patients may benefit from treatment being commenced immediately on diagnosis ra... Read More about Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?.

RCT of treatments for pyoderma gangrenosum: time to get involved (2010)
Journal Article
Mitchell, E. (2010). RCT of treatments for pyoderma gangrenosum: time to get involved. Wounds UK, 6(4), 27-32

Background: Pyoderma gangrenosum (PG) is a rare, painful ulcerating skin condition that is often associated with underlying systemic disease such as inflammatory bowel disease, rheumatoid arthritis and haematological malignancies. There has been litt... Read More about RCT of treatments for pyoderma gangrenosum: time to get involved.

Systematic review of levodopa dose equivalency reporting in Parkinson's disease: Systematic Review of LED Reporting in PD (2010)
Journal Article
Tomlinson, C. L., Stowe, R., Patel, S., Rick, C., Gray, R., & Clarke, C. E. (2010). Systematic review of levodopa dose equivalency reporting in Parkinson's disease: Systematic Review of LED Reporting in PD. Movement Disorders, 25(15), 2649-2653. https://doi.org/10.1002/mds.23429

Interpretation of clinical trials comparing different drug regimens for Parkinson's disease (PD) is complicated by the different dose intensities used: higher doses of levodopa and, possibly, other drugs produce better symptomatic control but more la... Read More about Systematic review of levodopa dose equivalency reporting in Parkinson's disease: Systematic Review of LED Reporting in PD.

Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment (2008)
Journal Article
(2008). Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment. Leukemia, 22, 1395-1401. https://doi.org/10.1038/leu.2008.125

Relapse in acute myeloid leukaemia (AML) is mediated by survival of leukaemic stem cells following remission-induction chemotherapy. It would therefore be useful to identify therapeutic agents that target leukaemic stem cells. We devised a flow cytom... Read More about Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment.