Outputs (106)

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection (2021)
Journal Article
Monaghan, T. M., Duggal, N. A., Rosati, E., Griffin, R., Hughes, J., Roach, B., Yang, D. Y., Wang, C., Wong, K., Saxinger, L., Pučić-Baković, M., Vučković, F., Klicek, F., Lauc, G., Tighe, P., Mullish, B. H., Blanco, J. M., McDonald, J. A., Marchesi, J. R., Xue, N., …Kao, D. H. (2021). A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection. Cells, 10(11), Article 3234. https://doi.org/10.3390/cells10113234

Fecal microbiota transplantation (FMT) is highly effective in recurrent Clostridioides difficile infection (CDI); increasing evidence supports FMT in severe or fulminant Clostridioides difficile infection (SFCDI). However, the multifactorial mechanis... Read More about A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection.

Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies (2021)
Journal Article
Dellschaft, N., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2022). Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Alimentary Pharmacology and Therapeutics, 55(3), 327-338. https://doi.org/10.1111/apt.16673

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide dat... Read More about Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies.

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., Doherty, M., Fox, C. P., Mallen, C. D., & Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783-2791. https://doi.org/10.1093/rheumatology/keab790

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study (2021)
Journal Article
Houdmont, J., Daliya, P., Theophilidou, E., Adiamah, A., Hassard, J., Lobo, D. N., & East Midlands Surgical Academic Network (EMSAN) Burnout Study Group. (2022). Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study. World Journal of Surgery, 46(1), 1-9. https://doi.org/10.1007/s00268-021-06351-6

Background: Surgeon burnout has implications for patient safety and workforce sustainability. The aim of this study was to establish the prevalence of burnout among surgeons in the UK during the COVID-19 pandemic.

Methods: This cross-sectional on... Read More about Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study.

Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered? (2021)
Journal Article
Ljungqvist, O., & Lobo, D. N. (2021). Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered?. JAMA Surgery, 157(1), 41-42. https://doi.org/10.1001/jamasurg.2021.5273

Rosenberg and colleagues1 first proposed the use of nonabsorbable oral antibiotic preparation (OAB) for colorectal surgery in 1971. In a randomized clinical trial, they demonstrated a reduction in surgical site infection and anastomotic leak rates af... Read More about Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered?.

Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis (2021)
Journal Article
Anis, F. S., Adiamah, A., Lobo, D. N., & Sanyal, S. (2022). Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis. Journal of Gastroenterology and Hepatology, 37(3), 446-454. https://doi.org/10.1111/jgh.15711

Background and Aim: This meta-analysis aimed to estimate the incidence of splanchnic vein thrombosis (SVT) in patients with acute pancreatitis and assess the effects of therapeutic anticoagulation. Methods: Systematic searches of the Medline, Embase,... Read More about Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis.

Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans (2021)
Journal Article
Hornby, H., Collado-González, M., Zhang, X., Abrehart, N., Alshammari, M., Bakalis, S., Mackie, A., & Marciani, L. (2021). Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans. Nutrients, 13(10), Article 3626. https://doi.org/10.3390/nu13103626

Oral processing of food results in the formation of food boluses, which are then swallowed and reach the stomach for further digestion. The number, size and surface properties of the boluses will affect their processing and emptying from the stomach.... Read More about Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans.

Management of disease-related malnutrition for patients being treated in hospital (2021)
Journal Article
Schuetz, P., Seres, D., Lobo, D. N., Gomes, F., Kaegi-Braun, N., & Stanga, Z. (2021). Management of disease-related malnutrition for patients being treated in hospital. Lancet, 398(10314), 1927-1938. https://doi.org/10.1016/S0140-6736%2821%2901451-3

Disease-related malnutrition in adult patients who have been admitted to hospital is a syndrome associated with substantially increased morbidity, disability, short-term and long-term mortality, impaired recovery from illness, and cost of care. There... Read More about Management of disease-related malnutrition for patients being treated in hospital.

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers (2021)
Journal Article
Whitfield, J. B., Schwantes-An, T. H., Darlay, R., Aithal, G. P., Atkinson, S. R., Bataller, R., Botwin, G., Chalasani, N. P., Cordell, H. J., Daly, A. K., Day, C. P., Eyer, F., Foroud, T., Gleeson, D., Goldman, D., Haber, P. S., Jacquet, J. M., Liang, T., Liangpunsakul, S., Masson, S., …Seth, D. (2022). A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers. Journal of Hepatology, 76(2), 275-282. https://doi.org/10.1016/j.jhep.2021.10.005

Background & Aims: Only a minority of excess alcohol drinkers develop cirrhosis. We developed and evaluated risk stratification scores to identify those at highest risk. Methods: Three cohorts (GenomALC-1: n = 1,690, GenomALC-2: n = 3,037, UK Biobank... Read More about A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.

Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation (2021)
Journal Article
Al-Awadi, A., Grove, J., Taylor, M., Valdes, A., Vijay, A., Bawden, S., Gowland, P., & Aithal, G. (2021). Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation. BMJ Open, 11(10), Article e045802. https://doi.org/10.1136/bmjopen-2020-045802

Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipo... Read More about Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation.