Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans

Hornby, Hannah; Collado-González, Mar; Zhang, Xue; Abrehart, Nichola; Alshammari, Meshari; Bakalis, Serafim; Mackie, Alan; Marciani, Luca

Abstract

Oral processing of food results in the formation of food boluses, which are then swallowed and reach the stomach for further digestion. The number, size and surface properties of the boluses will affect their processing and emptying from the stomach. Knowledge of these parameters, however, is incomplete due to limitations of the techniques used. In this work, non-invasive magnetic resonance imaging (MRI) was used for the first time to measure boluses in the stomach a few minutes after swallowing. Three groups of nine healthy participants were fed three different meals: chicken and roasted vegetables (Meal 1), bread and jam (Meal 2) and cheese and yogurt (Meal 3), and then, their stomach content was imaged. The median number of boluses within the stomach was 282, 106 and 9 for Meal 1, Meal 2 and Meal 3 (p < 0.0001) with an average volume of 0.47 mL, 2.4 mL and 13.6 mL, respectively (p < 0.0001). The cohesiveness as well as the meal composition seem to play a key role in the resulting boluses. These new in vivo data from undisturbed organ imaging can improve knowledge of the digestion process, which will, in turn, inform in vitro and in silico modelling of digestion, thus improving their in vitro/in vivo relevance.

Citation

Hornby, H., Collado-González, M., Zhang, X., Abrehart, N., Alshammari, M., Bakalis, S., …Marciani, L. (2021). Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans. Nutrients, 13(10), Article 3626. https://doi.org/10.3390/nu13103626

• Journal Article Type: Article
• Acceptance Date: Oct 12, 2021
• Online Publication Date: Oct 16, 2021
• Publication Date: Oct 16, 2021
• Deposit Date: Jan 30, 2022
• Publicly Available Date: Jan 31, 2022
• Journal: Nutrients
• Electronic ISSN: 2072-6643
• Publisher: MDPI AG
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 10
• Article Number: 3626
• DOI: https://doi.org/10.3390/nu13103626
• Keywords: Food Science; Nutrition and Dietetics
• Public URL: https://nottingham-repository.worktribe.com/output/7356498
• Publisher URL: https://www.mdpi.com/2072-6643/13/10/3626