Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies

Dellschaft, Neele; Hoad, Caroline; Marciani, Luca; Gowland, Penny; Spiller, Robin

Abstract

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide data for adequately powering future studies in this area. Methods: This collation brings together 29 studies including 954 participants (530 healthy, 54 diverticulosis, 255 IBS, 53 functional constipation, 12 cystic fibrosis, 15 Crohn's disease, 20 coeliac disease, 15 scleroderma) which have been carried out in a single centre using comparable study designs. Results: Fasting SBWC (mean 82 [SD 65]mL) shows high variability with a small decline with advancing age (healthy volunteers only; individual patient data). Fasting values are increased in untreated coeliac disease (202 [290]mL, P=0.004). Post-prandial SBWC shows less intra-individual variability than fasting values in healthy volunteers. SBWC is increased by eating, most markedly by high fat meals but also by fibre, both viscous and particulate. Indigestible residue accumulates in late post-prandial period but empties soon after ingestion of a high calorie meal which produces a significant drop (by 50 [52]mL) in healthy volunteers. The associated fall in SBWC is abnormal in people with cystic fibrosis (SBWC reduced by 10 [121]mL, P=0.002) and in people with irritable bowel syndrome with diarrhoea (SBWC reduced by 17 [43] mL, P=0.007). Conclusions: SBWC as assessed by MRI is a valuable biomarker indicating the balance of secretion and absorption in health and disease and the impact of treatments.

Citation

Dellschaft, N., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2022). Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Alimentary Pharmacology and Therapeutics, 55(3), 327-338. https://doi.org/10.1111/apt.16673

• Journal Article Type: Article
• Acceptance Date: Oct 13, 2021
• Online Publication Date: Oct 30, 2021
• Publication Date: Feb 1, 2022
• Deposit Date: Oct 25, 2021
• Publicly Available Date: Oct 31, 2022
• Journal: Alimentary Pharmacology and Therapeutics
• Print ISSN: 0269-2813
• Electronic ISSN: 1365-2036
• Peer Reviewed: Peer Reviewed
• Volume: 55
• Issue: 3
• Pages: 327-338
• DOI: https://doi.org/10.1111/apt.16673
• Keywords: Pharmacology (medical); Gastroenterology; Hepatology
• Public URL: https://nottingham-repository.worktribe.com/output/6535901
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/apt.16673
• Additional Information: This is the peer reviewed version of the following article: Dellschaft, N, Hoad, C, Marciani, L, Gowland, P, Spiller, R. Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Aliment Pharmacol Ther. 2022; 55: 327– 338., which has been published in final form at https://doi.org/10.1111/apt.16673. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.