Outputs (831)

Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial (2013)
Journal Article
Bath-Hextall, F., Ozolins, M., Armstrong, S. J., Colver, G. B., Perkins, W., Miller, P. S., & Williams, H. C. (2014). Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial. Lancet Oncology, 15(1), 96-105. https://doi.org/10.1016/S1470-2045%2813%2970530-8

Background
Basal-cell carcinoma is the most common form of skin cancer and its incidence is increasing worldwide. We aimed to assess the effectiveness of imiquimod cream versus surgical excision in patients with low-risk basal-cell carcinoma.

Met... Read More about Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial.

Can theory of mind deficits be measured reliably in people with mild and moderate Alzheimer’s dementia? (2013)
Journal Article
Choong, C. S., & Doody, G. A. (2013). Can theory of mind deficits be measured reliably in people with mild and moderate Alzheimer’s dementia?. BMC Psychology, 1(Decemb), Article 9. https://doi.org/10.1186/2050-7283-1-28

Background
Patients suffering from Alzheimer’s dementia develop difficulties in social functioning. This has led to an interest in the study of “theory of mind” in this population. However, difficulty has arisen because the associated cognitive dema... Read More about Can theory of mind deficits be measured reliably in people with mild and moderate Alzheimer’s dementia?.

Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors (2013)
Journal Article
Rodriguez Gutierrez, D., Awwad, A., Meijer, L., Manita, M., Jaspan, T., Dineen, R. A., Grundy, R. G., & Auer, D. P. (in press). Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. American Journal of Neuroradiology, 35(5), https://doi.org/10.3174/ajnr.A3784

BACKGROUND AND PURPOSE: Qualitative radiologic MR imaging review affords limited differentiation among types of pediatric posterior fossa brain tumors and cannot detect histologic or molecular subtypes, which could help to stratify treatment. This st... Read More about Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors.

Spending by primary care practices-does it show what we expect? (2013)
Journal Article
James, M., & Stokes, E. (2014). Spending by primary care practices-does it show what we expect?. International Journal of Health Planning and Management, 29(3), 244-259. https://doi.org/10.1002/hpm.2224

Background
Over recent years, a number of policies and financial incentives in primary care have been proposed to tackle issues such as deprivation and health outcomes. This article investigates the association between healthcare spending, deprivati... Read More about Spending by primary care practices-does it show what we expect?.

Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data (2013)
Journal Article
Shah, M., Orton, E., Tata, L., Gomes, C., & Kendrick, D. (2013). Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data. Burns, 39(7), https://doi.org/10.1016/j.burns.2013.03.022

Scald injury is common, accounting for half of all burns in pre-school children. Most scalds are preventable and health professionals can play an important role in targeting interventions to those at greatest risk. However, the potential for routinel... Read More about Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data.

Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects (2013)
Journal Article
Chaddock, G., Lam, C., Hoad, C., Costigan, C., Cox, E. F., Placidi, E., Thexton, I., Wright, J., Blackshaw, P. E., Perkins, A. C., Marciani, L., Gowland, P. A., & Spiller, R. C. (2014). Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects. Neurogastroenterology and Motility, 26(2), 205-214. https://doi.org/10.1111/nmo.12249

Background: Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation. The aim of this study was to compare novel magnetic resonance imaging (MRI) tests for mea... Read More about Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects.

Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix (2013)
Journal Article
Rahman, C. V., Smith, S. J., Morgan, P. S., Langmack, K. A., Clarke, P. A., Ritchie, A. A., Macarthur, D. C., Rose, F. R., Shakesheff, K. M., Grundy, R. G., & Rahman, R. (2013). Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PLoS ONE, 8(10), Article e77435. https://doi.org/10.1371/journal.pone.0077435

INTRODUCTION

Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the potential to better target micro-deposits of cancer cells in brain parenchyma beyond the resected cavity. Here we evaluate clinical utility... Read More about Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix.

Exon skipping and gene transfer restore dystrophin expression in human induced pluripotent stem cells-cardiomyocytes harboring DMD mutations (2013)
Journal Article
Dick, E., Kalra, S., Anderson, D., George, V., Ritso, M., Laval, S. H., Barresi, R., Asrtsma-Rus, A., Lochmueller, H., & Denning, C. (2013). Exon skipping and gene transfer restore dystrophin expression in human induced pluripotent stem cells-cardiomyocytes harboring DMD mutations. Stem Cells and Development, 22(20), https://doi.org/10.1089/scd.2013.0135

With an incidence of 1:3,500 to 5,000 in male children, Duchenne muscular dystrophy (DMD) is an X-linked disorder in which progressive muscle degeneration occurs and affected boys usually die in their twenties or thirties. Cardiac involvement occurs... Read More about Exon skipping and gene transfer restore dystrophin expression in human induced pluripotent stem cells-cardiomyocytes harboring DMD mutations.

The use of routine outcome measures in two child and adolescent mental health services: a completed audit cycle (2013)
Journal Article
Hall, C. L., Moldavsky, M., Baldwin, L., Marriott, M., Newell, K., Taylor, J., Sayal, K., & Hollis, C. (2013). The use of routine outcome measures in two child and adolescent mental health services: a completed audit cycle. BMC Psychiatry, 13(270), https://doi.org/10.1186/1471-244X-13-270

Background:
Routine outcome measurement (ROM) is important for assessing the clinical effectiveness of health services and for monitoring patient outcomes. Within Child and Adolescent Mental Health Services (CAMHS) in the UK the adoption of ROM in C... Read More about The use of routine outcome measures in two child and adolescent mental health services: a completed audit cycle.

A psychometric comparison of two carer quality of life questionnaires in Huntington's disease: implications for neurodegenerative disorders - a response to: Hagell and Smith (2013) Journal of Huntington’s Disease 2(3) 315-322 (2013)
Journal Article
Aubeeluck, A., Buchanan, H., & Stupple, E. J. (2013). A psychometric comparison of two carer quality of life questionnaires in Huntington's disease: implications for neurodegenerative disorders - a response to: Hagell and Smith (2013) Journal of Huntington’s Disease 2(3) 315-322. Journal of Huntington's Disease, 2(4),