Outputs (834)

Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival (2020)
Journal Article
Joseph, C., Alsaleem, M., Orah, N., Narasimha, P. L., Miligy, I. M., Kurozumi, S., Ellis, I. O., Mongan, N. P., Green, A. R., & Rakha, E. A. (2020). Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. Breast Cancer Research and Treatment, 182, 267–282. https://doi.org/10.1007/s10549-020-05670-x

Purpose: MMP9 is a matricellular protein associated with extracellular matrix (ECM) remodelling, that promotes tumour progression, and modulates the activity of cell adhesion molecules and cytokines. This study aims to assess the prognostic value of... Read More about Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival.

Exploration of temperature and shelf-life dependency of the therapeutically available Insulin Detemir (2020)
Journal Article
Beji, O., Gillis, R. B., Dinu, V., Jiwani, S. I., Gyasi-Antwi, P., Fisk, I. D., Meal, A., Morgan, P. S., Harding, S. E., Huang, S., Agugini, G., Fedele, F., & Adams, G. G. (2020). Exploration of temperature and shelf-life dependency of the therapeutically available Insulin Detemir. European Journal of Pharmaceutics and Biopharmaceutics, 152, 340-347. https://doi.org/10.1016/j.ejpb.2020.05.016

© 2020 Elsevier B.V. Purpose: Insulin, in typical use, undergoes multiple changes in temperature; from refrigerator, to room temperature, to body temperature. Although long-term storage temperature has been well-studied, the short term changes to ins... Read More about Exploration of temperature and shelf-life dependency of the therapeutically available Insulin Detemir.

Correlation between breast cancer and lifestyle within the Gulf Cooperation Council countries: A systematic review (2020)
Journal Article
Tanner, L. T. A., & Cheung, K. L. (2020). Correlation between breast cancer and lifestyle within the Gulf Cooperation Council countries: A systematic review. World Journal of Clinical Oncology, 11(4), 217-242. https://doi.org/10.5306/wjco.v11.i4.217

BACKGROUND
In the six Gulf Cooperation Council countries (GCCCs), Bahrain, Saudi Arabia, Kuwait, Oman, Qatar and the United Arab Emirates, breast cancer (BC) is the greatest cause of cancer incidence and mortality. Obesity and physical inactivity ar... Read More about Correlation between breast cancer and lifestyle within the Gulf Cooperation Council countries: A systematic review.

Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose (2020)
Journal Article
van Munster, J. M., Daly, P., Blythe, M. J., Ibbett, R., Kokolski, M., Gaddipati, S., Lindquist, E., Singan, V. R., Barry, K. W., Lipzen, A., Ngan, C. Y., Petzold, C. J., Chan, L. J. G., Arvas, M., Raulo, R., Pullan, S. T., Delmas, S., Grigoriev, I. V., Tucker, G. A., Simmons, B. A., & Archer, D. B. (2020). Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose. Biotechnology for Biofuels, 13(1), Article 69. https://doi.org/10.1186/s13068-020-01702-2

Background
Understanding how fungi degrade lignocellulose is a cornerstone of improving renewables-based biotechnology, in particular for the production of hydrolytic enzymes. Considerable progress has been made in investigating fungal degradation d... Read More about Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose.

Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups (2020)
Journal Article
Taylor, C., Tan, S., McClaughry, R., & Sharkey, D. (2020). Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups. Neonatology, 117(4), 513–516. https://doi.org/10.1159/000506427

Background: Hospital-acquired viral respiratory tract infections (VRTIs) cause significant morbidity and mortality in neonatal patients. This includes escalation of respiratory support, increased length of hospital stay, and need for home oxygen, as... Read More about Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups.

The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men (2020)
Journal Article
Davies, R. W., Bass, J. J., Carson, B. P., Norton, C., Kozior, M., Wilkinson, D. J., Brook, M. S., Atherton, P. J., Smith, K., & Jakeman, P. M. (2020). The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men. Nutrients, 12(3), Article 845. https://doi.org/10.3390/nu12030845

Background: The aim of this study was to investigate the effect of whey protein supplementation on myofibrillar protein synthesis (myoPS) and muscle recovery over a 7-d period of intensified resistance training (RT). Methods: In a double-blind random... Read More about The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men.

Treatment strategies and survival outcomes in breast cancer (2020)
Journal Article
Cheung, K. L. (2020). Treatment strategies and survival outcomes in breast cancer. Cancers, 12(3), Article 735. https://doi.org/10.3390/cancers12030735

Treatment strategies for breast cancer are wide-ranging and often based on a multi-modality approach, depending on the stage and biology of the tumour and the acceptance and tolerance of the patient. They may include surgery, radiotherapy, and system... Read More about Treatment strategies and survival outcomes in breast cancer.

A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids (2020)
Journal Article
Stamatopoulos, K., Pathak, S., Marciani, L., & Turner, D. (2020). A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids. Molecular Pharmaceutics, 17(4), 1310-1323. https://doi.org/10.1021/acs.molpharmaceut.0c00019

In vivo studies have shown cyclic bile salt (BS) outputs during fasting whereas higher amounts have been observed in fed states. This leads to fluctuations of intestinal BS concentrations ([BS]) that can affect the rate and extent of absorption of li... Read More about A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids.

Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review (2020)
Journal Article
Meek, C., Topcu, G., Moghaddam, N., & das Nair, R. (2021). Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review. Disability and Rehabilitation, 43(22), 3135-3146. https://doi.org/10.1080/09638288.2020.1734105

Purpose: To provide an overview of the experiences and needs of patients adjusting to life after receiving a diagnosis of secondary progressive multiple sclerosis (SPMS).

Method: We conducted a meta-ethnographic synthesis of qualitative studies on... Read More about Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review.

High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial (2020)
Journal Article
Blackwell, J. E. M., Doleman, B., Boereboom, C. L., Morton, A., Williams, S., Atherton, P., Smith, K., Williams, J. P., Phillips, B. E., & Lund, J. N. (2020). High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial. Prostate Cancer and Prostatic Diseases, 23, 696–704. https://doi.org/10.1038/s41391-020-0219-1

Objectives

To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks.

Subjects/patients and methods

A randomised... Read More about High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial.