Outputs (831)

BioDynaMo: a modular platform for high-performance agent-based simulation (2021)
Journal Article
Breitwieser, L., Hesam, A., de Montigny, J., Vavourakis, V., Iosif, A., Jennings, J., Kaiser, M., Manca, M., Di Meglio, A., & Al-Ars, Z. (2022). BioDynaMo: a modular platform for high-performance agent-based simulation. Bioinformatics, 38(2), 453-460. https://doi.org/10.1093/bioinformatics/btab649

Motivation

Agent-based modeling is an indispensable tool for studying complex biological systems. However, existing simulation platforms do not always take full advantage of modern hardware and often have a field-specific software design.

Resul... Read More about BioDynaMo: a modular platform for high-performance agent-based simulation.

Organisation kindness (2021)
Book Chapter
Cooper, N., & Evans, B. (2021). Organisation kindness. In A. Frain, S. Murphy, & J. Frain (Eds.), ABC of Clinical Resilience. Wiley-Blackwell

Book abstract:

For the healthcare professional, clinical resilience is about reconnecting with those stirrings which first motivated us to spend a career in the service of others. It is about recovering and maintaining the 'joy of practice' which... Read More about Organisation kindness.

Connectivity within regions characterizes epilepsy duration and treatment outcome (2021)
Journal Article
Chen, X., Wang, Y., Kopetzky, S. J., Butz‐Ostendorf, M., & Kaiser, M. (2021). Connectivity within regions characterizes epilepsy duration and treatment outcome. Human Brain Mapping, 42(12), 3777-3791. https://doi.org/10.1002/hbm.25464

Finding clear connectome biomarkers for temporal lobe epilepsy (TLE) patients, in particular at early disease stages, remains a challenge. Currently, the whole-brain structural connectomes are analyzed based on coarse parcellations (up to 1,000 nodes... Read More about Connectivity within regions characterizes epilepsy duration and treatment outcome.

Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus (2021)
Journal Article
Allen, C. M., Hall, C. A., Cox, N. E., Ryan, H., De Beer, T., & O'Donoghue, M. F. (2021). Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus. Epilepsy & Behavior Reports, 16, Article 100456. https://doi.org/10.1016/j.ebr.2021.100456

The ketogenic diet (KD) may have a role in treating super-refractory status epilepticus (SRSE). Predominantly used in paediatric epilepsy, there are few reports of its use in adults. We describe a 19-year-old man with UBE2A deficiency syndrome, drug... Read More about Adjunctive use of the ketogenic diet in a young adult with UBE2A deficiency syndrome and super-refractory status epilepticus.

Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity (2020)
Journal Article
Gascoyne, L. E., Brookes, M. J., Rathnaiah, M., Zia Ul Haq Katshu, M., Koelewijn, L., Williams, G., Kumar, J., Walters, J. T., Seedat, Z. A., Palaniyappan, L., William Deakin, J., Singh, K. D., Liddle, P. F., & Morris, P. G. (2021). Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity. NeuroImage: Clinical, 29, Article 102524. https://doi.org/10.1016/j.nicl.2020.102524

Magnetoencephalography (MEG) measures magnetic fields generated by synchronised neural current flow and provides direct inference on brain electrophysiology and connectivity, with high spatial and temporal resolution. The movement-related beta decrea... Read More about Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity.

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women (2020)
Journal Article
Steinthorsdottir, V., McGinnis, R., Williams, N. O., Stefansdottir, L., Thorleifsson, G., Shooter, S., Fadista, J., Sigurdsson, J. K., Auro, K. M., Berezina, G., Borges, M., Bumpstead, S., Bybjerg-Grauholm, J., Colgiu, I., Dolby, V. A., Dudbridge, F., Engel, S. M., Franklin, C. S., Frigge, M. L., Frisbaek, Y., …Morgan, L. (2020). Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nature Communications, 11(1), https://doi.org/10.1038/s41467-020-19733-6

Ion channels as therapeutic targets in high grade gliomas (2020)
Journal Article
Griffin, M., Khan, R., Basu, S., & Smith, S. (2020). Ion channels as therapeutic targets in high grade gliomas. Cancers, 12(10), Article 3068. https://doi.org/10.3390/cancers12103068

Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15 months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS cancer-related death in children and adults due to the aggressive nature of t... Read More about Ion channels as therapeutic targets in high grade gliomas.

Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro (2020)
Journal Article
Velickovic, K., Lugo Leija, H. A., Surrat, A., Kim, D.-H., Sacks, H., Symonds, M. E., & Sottile, V. (2020). Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro. Cellular Physiology and Biochemistry, 54(5), 917-927. https://doi.org/10.33594/000000278

Background/Aims: Glutamine is the most abundant amino acid in the body and has a metabolic role as a precursor for protein, amino sugar and nucleotide synthesis. After glucose, glutamine is the main source of energy in cells and has recently been sho... Read More about Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro.

What are the development priorities for management of type 2 diabetes by general practitioners in Ningbo, China: a qualitative study of patients’ and practitioners’ perspectives (2020)
Journal Article
Woolley, A., Li, L., Solomon, J., Li, J., Huang, K., Chahal, P., Chahal, P., Tu, G., Chahal, P., & Chattopadhyay, K. (2020). What are the development priorities for management of type 2 diabetes by general practitioners in Ningbo, China: a qualitative study of patients’ and practitioners’ perspectives. BMJ Open, 10(9), Article e037215. https://doi.org/10.1136/bmjopen-2020-037215

Objectives: To explore patient and general practitioner (GP)’s perspectives on primary care management of patients with type 2 diabetes (T2DM) in Ningbo, China. We aim to understand the current benefits and challenges, and to identify development pri... Read More about What are the development priorities for management of type 2 diabetes by general practitioners in Ningbo, China: a qualitative study of patients’ and practitioners’ perspectives.

Multimodal virtual environments: an opportunity to improve fire safety training? (2020)
Journal Article
Lawson, G., Roper, T., Shaw, E., Hsieh, M.-K., & Cobb, S. V. (2020). Multimodal virtual environments: an opportunity to improve fire safety training?. Policy and Practice in Health and Safety, 18(2), 155-168. https://doi.org/10.1080/14773996.2020.1796085

Fires and fire-related fatalities remain a tragic and frequent occurrence. Evidence has shown that humans adopt sub-optimal behaviours during fire incidents and, therefore, training is one possible means to improve occupant survival rates. We present... Read More about Multimodal virtual environments: an opportunity to improve fire safety training?.