Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity

Gascoyne, Lauren E.; Brookes, Matthew J.; Rathnaiah, Mohanbabu; Zia Ul Haq Katshu, Mohammad; Koelewijn, Loes; Williams, Gemma; Kumar, Jyothika; Walters, James T.R.; Seedat, Zelekha A.; Palaniyappan, Lena; William Deakin, J.F.; Singh, Krish D.; Liddle, Peter F.; Morris, Peter G.

Abstract

Magnetoencephalography (MEG) measures magnetic fields generated by synchronised neural current flow and provides direct inference on brain electrophysiology and connectivity, with high spatial and temporal resolution. The movement-related beta decrease (MRBD) and the post-movement beta rebound (PMBR) are well-characterised effects in magnetoencephalography (MEG), with the latter having been shown to relate to long-range network integrity. Our previous work has shown that the PMBR is diminished (relative to controls) in a group of schizophrenia patients. However, little is known about how this effect might differ in patients at different stages of illness and degrees of clinical severity. Here, we extend our previous findings showing that the MEG derived PMBR abnormality in schizophrenia exists in 29 recent-onset and 35 established cases (i.e., chronic patients), compared to 42 control cases. In established cases, PMBR is negatively correlated with severity of disorganization symptoms. Further, using a hidden Markov model analysis, we show that transient pan-spectral oscillatory ”bursts”, which underlie the PMBR, differ between healthy controls and patients. Results corroborate that PMBR is associated with disorganization of mental activity in schizophrenia.

Citation

Gascoyne, L. E., Brookes, M. J., Rathnaiah, M., Zia Ul Haq Katshu, M., Koelewijn, L., Williams, G., Kumar, J., Walters, J. T., Seedat, Z. A., Palaniyappan, L., William Deakin, J., Singh, K. D., Liddle, P. F., & Morris, P. G. (2021). Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity. NeuroImage: Clinical, 29, Article 102524. https://doi.org/10.1016/j.nicl.2020.102524

• Journal Article Type: Article
• Acceptance Date: Dec 1, 2020
• Online Publication Date: Dec 3, 2020
• Publication Date: Jan 1, 2021
• Deposit Date: Dec 9, 2020
• Publicly Available Date: Jan 4, 2021
• Journal: NeuroImage: Clinical
• Electronic ISSN: 2213-1582
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Article Number: 102524
• DOI: https://doi.org/10.1016/j.nicl.2020.102524
• Keywords: Cognitive Neuroscience; Radiology Nuclear Medicine and imaging; Neurology; Clinical Neurology
• Public URL: https://nottingham-repository.worktribe.com/output/5124605
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2213158220303612