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Outputs (831)

Continuous Glucose Monitoring in the management of medication in care home residents with Type 2 Diabetes (eDMED): A protocol for a feasibility study (2025)
Journal Article
Welford, A. E., Ridgeway, J., Gillies, C., Choudhary, P., Hegde, V. 4., Khunti, K., & Seidu, S. (2025). Continuous Glucose Monitoring in the management of medication in care home residents with Type 2 Diabetes (eDMED): A protocol for a feasibility study. Diabetes Therapy, https://doi.org/10.1007/s13300-025-01740-9

Aims:
Overprescribing is common in older adults with diabetes, potentially leading to hospitalisation and reduced quality of life. Additionally, diabetes care in older adults is often complicated by multiple interacting conditions and cognitive im... Read More about Continuous Glucose Monitoring in the management of medication in care home residents with Type 2 Diabetes (eDMED): A protocol for a feasibility study.

Recorded mental health recovery narratives for people with mental health problems and informal carers: the NEON research programme including 3 RCTs (2025)
Journal Article
Slade, M., Rennick-Egglestone, S., Ali, Y., Newby, C., Yeo, C., Roe, J., Hui, A., Charles, A., Hare-Duke, L., Paterson, L., Gavan, S. P., Slade, E., Kotera, Y., Priebe, S., Thornicroft, G., Keppens, J., Elliott, R., Pollock, K., Repper, J., Robotham, D., …Llewellyn-Beardsley, J. (in press). Recorded mental health recovery narratives for people with mental health problems and informal carers: the NEON research programme including 3 RCTs. Programme Grants for Applied Research,

Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom (2025)
Journal Article
Wilson, L. E., Knaggs, R. D., Avery, A. J., Thornley, T., Moss, J., Baamer, R. M., & Boyd, M. J. (2025). Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom. PAIN Reports, 10(2), Article e1246. https://doi.org/10.1097/PR9.0000000000001246

Introduction:
Knowledge of the potential for harm and adverse effects from long-term opioid medicines has led to reduced prescribing in recent years. However, the number of patients receiving opioid prescriptions from primary care in England remains... Read More about Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom.

Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception (2025)
Journal Article
McGing, J. J., Serres, S., Nicholas, R., Gupta, A., Radford, S. J., Nixon, A. V., Mallinson, J., Bradley, C., Bawden, S., Francis, S. T., Greenhaff, P. L., & Moran, G. W. (2025). Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception. Journal of Crohn's and Colitis, 19(1), Article jjae194. https://doi.org/10.1093/ecco-jcc/

Background & Objective

IBD fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and functio... Read More about Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception.

Wound imaging software and digital platform to assist review of surgical wounds using patient smartphones: The development and evaluation of artificial intelligence (WISDOM AI study) (2024)
Journal Article
Rochon, M., Tanner, J., Jurkiewicz, J., Beckhelling, J., Aondoakaa, A., Wilson, K., Dhoonmoon, L., Underwood, M., Mason, L., Harris, R., & Cariaga, K. (2024). Wound imaging software and digital platform to assist review of surgical wounds using patient smartphones: The development and evaluation of artificial intelligence (WISDOM AI study). PLoS ONE, 19(12), Article e0315384. https://doi.org/10.1371/journal.pone.0315384

Introduction Surgical patients frequently experience post-operative complications at home. Digital remote monitoring of surgical wounds via image-based systems has emerged as a promising solution for early detection and intervention. However, the inc... Read More about Wound imaging software and digital platform to assist review of surgical wounds using patient smartphones: The development and evaluation of artificial intelligence (WISDOM AI study).

Synthetic cerebral blood vessel generator for training anatomically plausible deep learning models (2024)
Presentation / Conference Contribution
Kenyon, G., Lau, S., Perperidis, A., CHAPPELL, M., & Jenkinson, M. (2024, July). Synthetic cerebral blood vessel generator for training anatomically plausible deep learning models. Presented at MIUA - Medical Image Understanding and Analysis - 2024, Manchester

Blood vessel networks, with their complex geometrical and topological characteristics, play a significant role in diagnosing and understanding various cerebrovascular diseases. Deep learning (DL) segmentation methods can aid in analysing these struct... Read More about Synthetic cerebral blood vessel generator for training anatomically plausible deep learning models.

Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task (2024)
Journal Article
Hock, R. M., Owusu-Amoah, N., Waite, L., Muir, C., Stevenson, C. W., Bonardi, C., & Cassaday, H. J. (2024). Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task. Behavioral Neuroscience, 138(6), 420-432. https://doi.org/10.1037/bne0000603

Healthy cognition requires inhibitory modulation of associative learning; conversely, impaired inhibitory discrimination is implicated in behavioral disorders. The medial prefrontal cortex (mPFC) and its dopamine innervation are key to understanding... Read More about Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task.

A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI) (2024)
Journal Article
Yule, A., Ng, C., Recto, A., Lockwood, F., Dellschaft, N. S., Hoad, C. L., Zagoya, C., Mainz, J. G., Major, G., Barr, H. L., Gowland, P. A., Stewart, I., Marciani, L., Spiller, R. C., & Smyth, A. R. (2024). A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI). Journal of Cystic Fibrosis, 23(5), 984-990. https://doi.org/10.1016/j.jcf.2024.08.001

Background

Gastrointestinal (GI) symptoms in cystic fibrosis (CF) are common and disruptive. The effect of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the GI tract is not fully understood. The aim was to use magnetic r... Read More about A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI).

Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences (2024)
Preprint / Working Paper
Deakin, B., Liddle, E., Rathnaiah, M., Gregory, C., Katshu, M., Wiliams, G., Conen, S., Smallman, R., Koelewijn, L. C., Anton, A., Kumar, J., Gasgoyne, L. E., Chen, C., Nikkheslat, N., Evans, J., Lanz, B., Walters, J., Talbot, P., Palaniyappan, L., Singh, K. D., …Liddle, P. F. Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences

It is widely thought that the onset of psychotic symptoms in schizophrenia may arise from an early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late residual damage phase associated with persistent negative symptoms.... Read More about Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences.