Outputs (17)

Patient and Public Involvement and Engagement for PhD Students (2023)
Preprint / Working Paper
Gladman, J. R. F., Stocks, J., Phillips, B., Horobin, A., Wragg, A., Mundey, M., Woodcock, R., Braybrooke, R., Junor, A., Hendy, C., Morgan, K., Prior, M., & Humes, D. Patient and Public Involvement and Engagement for PhD Students

This paper aims to provide useful advice regarding the development of skills for patient and public involvement and engagement (PPIE) in research. The authors of this paper comprise experienced PhD supervisors and trainers, researchers leading PPIE a... Read More about Patient and Public Involvement and Engagement for PhD Students.

Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing (2020)
Journal Article
Wilkinson, D. J., Rodriguez-Blanco, G., Dunn, W. B., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Smith, K., Gallagher, I. J., & Atherton, P. J. (2020). Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing. Aging, 12(13), 12517-12533. https://doi.org/10.18632/aging.103513

Ageing compromises skeletal muscle mass and function through poorly defined molecular aetiology. Here we have used untargeted metabolomics using UHPLC-MS to profile muscle tissue from young (n=10, 25±4y), middle aged (n=18, 50±4y) and older (n=18, 70... Read More about Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing.

High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial (2020)
Journal Article
Blackwell, J. E. M., Doleman, B., Boereboom, C. L., Morton, A., Williams, S., Atherton, P., Smith, K., Williams, J. P., Phillips, B. E., & Lund, J. N. (2020). High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial. Prostate Cancer and Prostatic Diseases, 23, 696–704. https://doi.org/10.1038/s41391-020-0219-1

Objectives

To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks.

Subjects/patients and methods

A randomised... Read More about High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial.

A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection (2019)
Journal Article
Hossain, T., Phillips, B. E., Doleman, B., Lund, J. N., & Williams, J. P. (2020). A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection. Clinical Nutrition, 39(7), 2055-2061. https://doi.org/10.1016/j.clnu.2019.09.009

Background

Resection of colorectal cancer (CRC) initiates inflammation, mediated at least partly by NFĸB (nuclear factor kappa-light-chain-enhancer of activated B-cells), leading to muscle catabolism and reduced physical performance. Eicosapentaen... Read More about A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection.

The effect of oral essential amino acids on incretin hormone production in youth and ageing (2019)
Journal Article
Abdulla, H., Bass, J., Stokes, T., Gorissen, S., McGlory, C., Phillips, B., Phillips, S., Smith, K., Idris, I., & Atherton, P. (2019). The effect of oral essential amino acids on incretin hormone production in youth and ageing. Endocrinology, Diabetes and Metabolism, 2(4), Article e00085. https://doi.org/10.1002/edm2.85

Background
The effect of substantive doses of essential amino acids (EAA) on incretin and insulin production, and the impact of age upon this effect, is ill‐defined.

Methods
A 15‐g oral EAA drink was administered to young (N = 8; 26 ± 4.4 years)... Read More about The effect of oral essential amino acids on incretin hormone production in youth and ageing.

Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients (2019)
Journal Article
Boereboom, C. L., Blackwell, J. E., Williams, J. P., Phillips, B. E., & Lund, J. N. (2019). Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients. Scandinavian Journal of Medicine and Science in Sports, 29(9), 1383-1391. https://doi.org/10.1111/sms.13460

Background: Preoperative cardiorespiratory fitness (CRF) in colorectal cancer patients has been shown to affect postoperative outcomes. The aim of this study was to test the feasibility of high-intensity interval training (HIT) for improving fitness... Read More about Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients.

Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation (2019)
Journal Article
Crossland, H., Pereira, S. L., Smith, K., Phillips, B. E., & Atherton, P. J. (2019). Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation. Journal of Functional Foods, 56, 216-223. https://doi.org/10.1016/j.jff.2019.03.022

Cocoa flavanols and fish oil omega-3 fatty acids are two bio-active nutrients that may improve muscle microvascular function, insulin sensitivity and mitochondrial function in older adults. We assessed changes in gene expression of these pathways in... Read More about Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation.

A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults (2018)
Journal Article
Din, U., Brook, M., Selby, A. L., Quinlan, J. I., Boereboom, C., Abdullah, H., Franchi, M., Narici, M. V., Phillips, B. E., Williams, J., Rathmacher, J. A., Wilkinson, D., Atherton, P. J., & Smith, K. (2019). A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults. Clinical Nutrition, 38(5), 2071-2078. https://doi.org/10.1016/j.clnu.2018.09.025

Age-related sarcopenia and dynapenia are associated with frailty and metabolic diseases. Resistance exercise training (RET) adjuvant to evidence-based nutritional intervention(s) have been shown as mitigating strategies. Given that HMB supplementatio... Read More about A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults.

Short-term (<8 weeks) high-intensity interval training in diseased cohorts (2018)
Journal Article
Blackwell, J. E., Doleman, B., Herrod, P., Ricketts, S., Phillips, B. E., Lund, J. N., & Williams, J. P. (2018). Short-term (

Background & Aim:
Exercise training regimes can lead to improvements in measures of cardiorespiratory fitness (CRF), improved general health, and reduced morbidity and overall mortality risk. High intensity interval training (HIIT) offers a time-eff... Read More about Short-term (<8 weeks) high-intensity interval training in diseased cohorts.

Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis (2018)
Journal Article
Herrod, P. J., Doleman, B., Blackwell, J. E., O’Boyle, F., Williams, J. P., Lund, J. N., & Phillips, B. E. (in press). Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis. Journal of the American Society of Hypertension, 12(4), https://doi.org/10.1016/j.jash.2018.01.008

The incidence of hypertension increases with advancing age and represents a significant burden of disease. Lifestyle modification represents the first-line intervention in treatment algorithms; however, the majority of evidence for this comes from st... Read More about Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis.