Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation

Crossland, Hannah; Pereira, Suzette L.; Smith, Kenneth; Phillips, Bethan E.; Atherton, Philip J.

Abstract

Cocoa flavanols and fish oil omega-3 fatty acids are two bio-active nutrients that may improve muscle microvascular function, insulin sensitivity and mitochondrial function in older adults. We assessed changes in gene expression of these pathways in muscle from two nutritional intervention studies in older healthy volunteers: (i) 6-weeks daily fish oil supplementation in older females (3.4 g/d; age: 64.4 ± 0.8 y, BMI: 26.2 ± 0.7 kg/m2), and (ii) 7-day daily cocoa flavanol supplementation in older males (1050 mg/d; age: 70.1 ± 0.9 y, BMI: 25.7 ± 0.6 kg/m2). There was a main effect of 6-weeks fish oil supplementation on angiogenesis gene expression, with no overall changes in mitochondrial or insulin signaling genes. 7-day cocoa supplementation elicited changes in extracellular matrix (ECM) related genes. Thus, the effects of fish oil supplementation on vascular remodeling in skeletal muscle, and ECM remodeling with cocoa supplementation have emerged as areas for future study.

Citation

Crossland, H., Pereira, S. L., Smith, K., Phillips, B. E., & Atherton, P. J. (2019). Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation. Journal of Functional Foods, 56, 216-223. https://doi.org/10.1016/j.jff.2019.03.022

• Journal Article Type: Article
• Acceptance Date: Mar 15, 2019
• Online Publication Date: Mar 22, 2019
• Publication Date: May 1, 2019
• Deposit Date: Apr 1, 2019
• Publicly Available Date: Mar 23, 2020
• Journal: Journal of Functional Foods
• Print ISSN: 1756-4646
• Electronic ISSN: 2214-9414
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 56
• Pages: 216-223
• DOI: https://doi.org/10.1016/j.jff.2019.03.022
• Keywords: Skeletal muscle; Angiogenesis; Mitochondria; Gene expression
• Public URL: https://nottingham-repository.worktribe.com/output/1724535
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1756464619301422#s0045
• Additional Information: This article is maintained by: Elsevier; Article Title: Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation; Journal Title: Journal of Functional Foods; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jff.2019.03.022; Content Type: article; Copyright: © 2019 The Authors. Published by Elsevier Ltd.
• Contract Date: Apr 1, 2019