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Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation

Crossland, Hannah; Pereira, Suzette L.; Smith, Kenneth; Phillips, Bethan E.; Atherton, Philip J.

Authors

Hannah Crossland

Suzette L. Pereira

KENNETH SMITH KEN.SMITH@NOTTINGHAM.AC.UK
Professor of Metabolic Mass Spectrometry

BETH PHILLIPS beth.phillips@nottingham.ac.uk
Professor of Translational Physiology

PHILIP ATHERTON philip.atherton@nottingham.ac.uk
Professor of Clinical, metabolic & Molecular Physiology



Abstract

Cocoa flavanols and fish oil omega-3 fatty acids are two bio-active nutrients that may improve muscle microvascular function, insulin sensitivity and mitochondrial function in older adults. We assessed changes in gene expression of these pathways in muscle from two nutritional intervention studies in older healthy volunteers: (i) 6-weeks daily fish oil supplementation in older females (3.4 g/d; age: 64.4 ± 0.8 y, BMI: 26.2 ± 0.7 kg/m2), and (ii) 7-day daily cocoa flavanol supplementation in older males (1050 mg/d; age: 70.1 ± 0.9 y, BMI: 25.7 ± 0.6 kg/m2). There was a main effect of 6-weeks fish oil supplementation on angiogenesis gene expression, with no overall changes in mitochondrial or insulin signaling genes. 7-day cocoa supplementation elicited changes in extracellular matrix (ECM) related genes. Thus, the effects of fish oil supplementation on vascular remodeling in skeletal muscle, and ECM remodeling with cocoa supplementation have emerged as areas for future study.

Citation

Crossland, H., Pereira, S. L., Smith, K., Phillips, B. E., & Atherton, P. J. (2019). Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation. Journal of Functional Foods, 56, 216-223. https://doi.org/10.1016/j.jff.2019.03.022

Journal Article Type Article
Acceptance Date Mar 15, 2019
Online Publication Date Mar 22, 2019
Publication Date May 1, 2019
Deposit Date Apr 1, 2019
Publicly Available Date Mar 23, 2020
Journal Journal of Functional Foods
Print ISSN 1756-4646
Electronic ISSN 2214-9414
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 56
Pages 216-223
DOI https://doi.org/10.1016/j.jff.2019.03.022
Keywords Skeletal muscle; Angiogenesis; Mitochondria; Gene expression
Public URL https://nottingham-repository.worktribe.com/output/1724535
Publisher URL https://www.sciencedirect.com/science/article/pii/S1756464619301422#s0045
Additional Information This article is maintained by: Elsevier; Article Title: Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation; Journal Title: Journal of Functional Foods; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jff.2019.03.022; Content Type: article; Copyright: © 2019 The Authors. Published by Elsevier Ltd.

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