The effect of oral essential amino acids on incretin hormone production in youth and ageing
Abdulla, H.; Bass, J.J.; Stokes, T.; Gorissen, S.H.M.; McGlory, C.; Phillips, B.E.; Phillips, S.M.; Smith, K.; Idris, I.; Atherton, P.J.
JOSEPH BASS JOSEPH.BASS2@NOTTINGHAM.AC.UK
BETH PHILLIPS email@example.com
KENNETH SMITH KEN.SMITH@NOTTINGHAM.AC.UK
Professor of Metabolic Mass Spectrometry
ISKANDAR IDRIS Iskandar.Idris@nottingham.ac.uk
Clinical Associate Professor & Honoraryconsultant Physician
PHILIP ATHERTON firstname.lastname@example.org
Professor of Clinical, metabolic & Molecular Physiology
The effect of substantive doses of essential amino acids (EAA) on incretin and insulin production, and the impact of age upon this effect, is ill‐defined.
A 15‐g oral EAA drink was administered to young (N = 8; 26 ± 4.4 years) and older (N = 8; 69 ± 3.8 years) healthy volunteers. Another group of younger volunteers (N = 9; 21 ± 1.9 years) was given IV infusions to achieve equivalent plasma amino acids (AA) profiles. Plasma AA, insulin, glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic peptide (GIP) were quantified over 2 hours.
In younger recruits, EAA‐induced rapid insulinaemia and aminoacidaemia with total amino acids(AA), EAA and branched chain amino acids (BCAA) matched between oral and IV groups. Insulin peaked at 39 ± 29 pmol L−1 at 30 minutes following oral feeding compared to 22 ± 9 pmol L−1 at 60 minutes following IV feeding (P: NS). EAA peaked at 3395 μmol L−1 at 45 minutes during IV infusion compared to 2892 μmol L−1 following oral intake (Feeding effect: P [less than] 0.0001. Oral vs IV feeding: P: NS). There was an 11% greater increase in insulin levels in the 120 minutes duration of the study in response to oral EAA as opposed to IV EAA. GIP increased following oral EAA (452 pmol L−1 vs 232 pmol L−1, P [less than] 0.05). Age did not impact insulin or incretins production.
Postprandial rises in EAA levels lead to rapid insulinaemia which is higher with oral compared with IV EAA, that is attributed more to GIP and unaffected by age. This finding supports EAA, on their own or as part of high‐protein meal, as nutritive therapeutics in impaired glycaemia and ageing.
Abdulla, H., Bass, J., Stokes, T., Gorissen, S., McGlory, C., Phillips, B., …Atherton, P. (2019). The effect of oral essential amino acids on incretin hormone production in youth and ageing. Endocrinology, Diabetes and Metabolism, 2(4), https://doi.org/10.1002/edm2.85
|Journal Article Type||Article|
|Acceptance Date||Jun 15, 2019|
|Online Publication Date||Jul 26, 2019|
|Deposit Date||Jul 8, 2019|
|Publicly Available Date||Aug 5, 2019|
|Peer Reviewed||Peer Reviewed|
|Keywords||Incretins, Insulin, Incretin effect, Essential amino acids, Ageing|
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