Outputs (25)

Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening (2025)
Presentation / Conference Contribution
Yong, L. X., Zhou, Z., Vallières, C., He, Y., Cuzzucoli Crucitti, V., Alexander, M. R., Avery, S., Wildman, R., & Irvine, D. (2024, August). Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening. Presented at International Conference on Computational & Experimental Engineering and Sciences, Singapore, Singapore

The fungal pathogen Candida albicans (C. albicans) is particularly problematic for immunocompromised patients and those with medical implants. Introducing Candida-resistant medical devices could potentially reduce mortality rates from such infections... Read More about Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening.

Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices (2024)
Journal Article
Yong, L. X., Sefton, J., Vallières, C., Rance, G. A., Hill, J., Cuzzucoli Crucitti, V., Dundas, A. A., Rose, F. R., Alexander, M. R., Wildman, R., He, Y., Avery, S. V., & Irvine, D. J. (2024). Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices. ACS Applied Materials and Interfaces, 16(40), 54508–54519. https://doi.org/10.1021/acsami.4c04833

This study reports the development of the first copolymer material that (i) is resistant to fungal attachment and hence biofilm formation, (ii) operates via a nonkilling mechanism, i.e., avoids the use of antifungal actives and the emergence of funga... Read More about Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices.

Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient (2024)
Journal Article
Rivers, G., Lion, A., Putri, N. R. E., Rance, G. A., Moloney, C., Taresco, V., Crucitti, V. C., Constantin, H., Evangelista Barreiros, M. I., Cantu, L. R., Tuck, C. J., Rose, F. R., Hague, R. J., Roberts, C. J., Turyanska, L., Wildman, R. D., & He, Y. (2024). Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient. Materials Today Advances, 22, Article 100493. https://doi.org/10.1016/j.mtadv.2024.100493

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing e... Read More about Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient.

Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient (2024)
Journal Article
Rivers, G., Lion, A., Rofiqoh Eviana Putri, N., Rance, G., Moloney, C., Taresco, V., Crucitti, V. C., Constantin, H., Inê Evangelista Barreiros, M., Cantu, L. R., Tuck, C., Rose, F. R. A. J., Hague, R. J. M., Roberts, C. J., Turyanska, L., Wildman, R. D., & He, Y. (2024). Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient. Materials Today Advances, 22, Article 100493. https://doi.org/10.1016/j.mtadv.2024.100493

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing e... Read More about Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient.

Co-assembling living material as an in vitro lung epithelial infection model (2023)
Journal Article
Wu, Y., Romero, M., Robertson, S. N., Fenn, S., Fisher, L., Willingham, I., Martinez Pomares, L., Ligorio, C., Hill, J., Bu, W., Zhou, Z., Wildman, R. D., Ghaemmaghami, A. M., Sun, H., Sun, J., Cámara, M., & Mata, A. (2024). Co-assembling living material as an in vitro lung epithelial infection model. Matter, 7(1), 216-236. https://doi.org/10.1016/j.matt.2023.10.029

Biofilms are robust living 3D materials that play key roles in nature but also cause major problems, such as tolerance to antibiotic treatment. Recreation of these living structures in vitro is critical to understand their biology and develop solutio... Read More about Co-assembling living material as an in vitro lung epithelial infection model.

A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection (2023)
Journal Article
Crawford, L. A., Cuzzucoli Crucitti, V., Stimpson, A., Morgan, C., Blake, J., Wildman, R. D., Hook, A. L., Alexander, M. R., Irvine, D. J., & Avery, S. V. (2023). A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection. Green Chemistry, 25(21), 8558-8569. https://doi.org/10.1039/d3gc01911j

Fungicidal compounds are actives widely used for crop protection from fungal infection, but they can also kill beneficial organisms, enter the food chain and promote resistant pathogen strains from overuse. Here we report the first field crop trial o... Read More about A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection.

Innate immune cell instruction using micron-scale 3D objects of varied architecture and polymer chemistry: The ChemoArchiChip (2023)
Journal Article
Vassey, M., Ma, L., Kämmerling, L., Mbadugha, C., Trindade, G. F., Figueredo, G. P., Pappalardo, F., Hutchinson, J., Markus, R., Rajani, S., Hu, Q., Winkler, D. A., Irvine, D. J., Hague, R., Ghaemmaghami, A. M., Wildman, R., & Alexander, M. R. (2023). Innate immune cell instruction using micron-scale 3D objects of varied architecture and polymer chemistry: The ChemoArchiChip. Matter, 6(3), 887-906. https://doi.org/10.1016/j.matt.2023.01.002

To design effective immunomodulatory implants, innate immune cell interactions at the surface of biomaterials need to be controlled and understood. The architectural design freedom of two-photon polymerization is used to produce arrays of surface-mou... Read More about Innate immune cell instruction using micron-scale 3D objects of varied architecture and polymer chemistry: The ChemoArchiChip.

Predictive Molecular Design and Structure–Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials (2023)
Journal Article
Cuzzucoli Crucitti, V., Ilchev, A., Moore, J. C., Fowler, H. R., Dubern, J.-F., Sanni, O., Xue, X., Husband, B. K., Dundas, A. A., Smith, S., Wildman, J. L., Taresco, V., Williams, P., Alexander, M. R., Howdle, S. M., Wildman, R. D., Stockman, R. A., & Irvine, D. J. (2023). Predictive Molecular Design and Structure–Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials. Biomacromolecules, 24(2), 576-591. https://doi.org/10.1021/acs.biomac.2c00721

Presented in this work is the use of a molecular descriptor, termed the α parameter, to aid in the design of a series of novel, terpene-based, and sustainable polymers that were resistant to biofilm formation by the model bacterial pathogen Pseudomon... Read More about Predictive Molecular Design and Structure–Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials.

Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing (2022)
Journal Article
Latif, A., Fisher, L. E., Dundas, A. A., Crucitti, V. C., Imir, Z., Lawler, K., Pappalard, F., Muir, B. W., Wildman, R., Irvine, D. J., Alexander, M. R., & Ghaemmaghami, A. M. (2024). Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing. Advanced Materials, 36(43), Article 2208364. https://doi.org/10.1002/adma.202208364

Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell type involv... Read More about Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing.

Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites (2022)
Preprint / Working Paper
he, Y., Begines, B., Trindade, G., Abdi, M., dubern, J.-F., Prina, E., Hook, A., Choong, G., Ledesma, J., Tuck, C., R. A. J. Rose, F., Hague, R., Roberts, C., De Focatiis, D., Ashcroft, I., Williams, P., Irvine, D., alexander, M., & Wildman, R. Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites

As our understanding of disease grows, it is becoming established that treatment needs to be personalized and targeted to the needs of the individual. In this paper we show that multi-material inkjet-based 3D printing, when backed with generative des... Read More about Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites.