Outputs (17)

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission (2022)
Journal Article
Liu, T., Shilliday, F., Cook, A. D., Zeeshan, M., Brady, D., Tewari, R., Sutherland, C. J., Roberts, A. J., & Moores, C. A. (2022). Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nature Communications, 13(1), Article 6988. https://doi.org/10.1038/s41467-022-34710-x

Plasmodium species cause malaria and kill hundreds of thousands annually. The microtubule-based motor kinesin-8B is required for development of the flagellated Plasmodium male gamete, and its absence completely blocks parasite transmission. To unders... Read More about Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.

Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission (2022)
Journal Article
Zeeshan, M., Brady, D., Markus, R., Vaughan, S., Ferguson, D., Holder, A. A., & Tewari, R. (2022). Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission. Life Science Alliance, 5(9), Article e202101329. https://doi.org/10.26508/lsa.202101329

The centriole/basal body (CBB) is an evolutionarily conserved organelle acting as a microtubule organising centre (MTOC) to nucleate cilia, flagella, and the centrosome. SAS4/CPAP is a conserved component associated with BB biogenesis in many model f... Read More about Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission.

Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages (2021)
Journal Article
Zeeshan, M., Pandey, R., Subudhi, A. K., Ferguson, D. J., Kaur, G., Rashpa, R., Nugmanova, R., Brady, D., Bottrill, A. R., Vaughan, S., Brochet, M., Bollen, M., Pain, A., Holder, A. A., Guttery, D. S., & Tewari, R. (2021). Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages. Communications Biology, 4(1), Article 760. https://doi.org/10.1038/s42003-021-02273-0

PP1 is a conserved eukaryotic serine/threonine phosphatase that regulates many aspects of mitosis and meiosis, often working in concert with other phosphatases, such as CDC14 and CDC25. The proliferative stages of the malaria parasite life cycle incl... Read More about Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages.

Molecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species (2021)
Journal Article
Koreny, L., Zeeshan, M., Barylyuk, K., Tromer, E. C., van Hooff, J. J., Brady, D., Ke, H., Chelaghma, S., Ferguson, D. J., Eme, L., Tewari, R., & Waller, R. F. (2021). Molecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species. PLoS Biology, 19(3), Article e3001081. https://doi.org/10.1371/journal.pbio.3001081

The apical complex is the instrument of invasion used by apicomplexan parasites, and the conoid is a conspicuous feature of this apparatus found throughout this phylum. The conoid, however, is believed to be heavily reduced or missing from Plasmodium... Read More about Molecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species.

MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life (2020)
Journal Article
Guttery, D. S., Ramaprasad, A., Ferguson, D. J. P., Zeeshan, M., Pandey, R., Brady, D., Holder, A. A., Pain, A., & Tewari, R. (2020). MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life. Cells, 9(12), Article 2590. https://doi.org/10.3390/cells9122590

The meiotic recombination 11 protein (MRE11) plays a key role in DNA damage response and maintenance of genome stability. However, little is known about its function during development of the malaria parasite Plasmodium. Here, we present a functional... Read More about MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life.

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission (2020)
Journal Article
Balestra, A. C., Zeeshan, M., Rea, E., Pasquarello, C., Brusini, L., Mourier, T., Subudhi, A. K., Klages, N., Arboit, P., Pandey, R., Brady, D., Vaughan, S., Holder, A. A., Pain, A., Ferguson, D. J., Hainard, A., Tewari, R., & Brochet, M. (2020). A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission. eLife, 9, Article e56474. https://doi.org/10.7554/eLife.56474

© 2020, Balestra et al. Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of... Read More about A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission.

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission (2020)
Journal Article
Le Roch, K. G., Holder, A. A., Bottrill, A. R., Stanway, R. R., Wall, R. J., Tewari, R., Pandey, R., Abel, S., Boucher, M., Zeeshan, M., Wheatley, S., Batugedara, G., Hollin, T., Daniel, E., Rea, E., Freville, A., Lu, X. M., Gupta, D., & Brady, D. (2020). Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission. Cell Reports, 30(6), 1883-1897.e6. https://doi.org/10.1016/j.celrep.2020.01.033

Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear. Here we examine... Read More about Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.

Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission (2019)
Journal Article
Zeeshan, M., Shilliday, F., Liu, T., Abel, S., Mourier, T., Ferguson, D. J. P., Rea, E., Stanway, R. R., Roques, M., Williams, D., Daniel, E., Brady, D., Roberts, A. J., Holder, A. A., Pain, A., Le, K. G., Le Roch, R. G., Moores, C. A., & Tewari, R. (2019). Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission. PLoS Pathogens, 15(10), Article e1008048. https://doi.org/10.1371/journal.ppat.1008048

Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the plus ends of spindle microtubules and regulate the dynamics of these ends due, at least in some... Read More about Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.

Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission (2019)
Journal Article
Zeeshan, M., Ferguson, D. J., Abel, S., Burrrell, A., Rea, E., Brady, D., Daniel, E., Delves, M., Vaughan, S., Holder, A. A., Le Roch, K. G., Moores, C. A., & Tewari, R. (2019). Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission. Life Science Alliance, 2(4), 1-13. https://doi.org/10.26508/lsa.201900488

Eukaryotic flagella are conserved microtubule-based organelles that drive cell motility. Plasmodium, the causative agent of malaria, has a single flagellate stage: the male gamete in the mosquito. Three rounds of endomitotic division in male gametocy... Read More about Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission.

Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages (2019)
Journal Article
Wall, R. J., Zeeshan, M., Katris, N. J., Limenitakis, R., Rea, E., Stock, J., Brady, D., Waller, R. F., Holder, A. A., & Tewari, R. (2019). Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages. Cellular Microbiology, 21(10), Article e13082. https://doi.org/10.1111/cmi.13082

The myosin superfamily comprises of actin‐dependent eukaryotic molecular motors important in a variety of cellular functions. Although well studied in many systems, knowledge of their functions in Plasmodium, the causative agent of malaria, is restri... Read More about Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages.