Outputs (28)

Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study (2023)
Journal Article
Zhu, R., Huttunen-Lenz, M., Stratton, G., Handjieva-Darlenska, T., Handjiev, S., Sundvall, J., …Raben, A. (2023). Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study. International Journal of Obesity, 47(9), 833–840. https://doi.org/10.1038/s41366-023-01328-y

Background/Objectives Some individuals with overweight/obesity may be relatively metabolically healthy (MHO) and have a lower risk of cardiovascular disease than those with metabolically unhealthy overweight/obesity (MUO). We aimed to compare change... Read More about Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study.

Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study (2023)
Journal Article
Della Corte, K., Jalo, E., Kaartinen, N. E., Simpson, L., Taylor, M. A., Muirhead, R., …Brand-Miller, J. (2023). Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study. Nutrients, 15(9), Article 2083. https://doi.org/10.3390/nu15092083

Background: Dietary sugars are often linked to the development of overweight and type 2 diabetes (T2D) but inconsistencies remain. Objective: We investigated associations of added, free, and total sugars, and glycaemic index (GI) with indices of gluc... Read More about Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study.

The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males (2023)
Journal Article
Trim, W. V., Walhin, J. P., Koumanov, F., Turner, J. E., Shur, N. F., Simpson, E. J., …Thompson, D. (2023). The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males. Clinical Nutrition, 42(4), 532-540. https://doi.org/10.1016/j.clnu.2023.02.006

Background & aims: It is unclear if dietary adjustments to maintain energy balance during reduced physical activity can offset inactivity-induced reductions in insulin sensitivity and glucose disposal to produce normal daily glucose concentrations an... Read More about The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males.

Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial (2023)
Journal Article
Simpson, E. J., Mendis, B., Dunlop, M., Schroeter, H., Kwik-Uribe, C., & Macdonald, I. A. (2023). Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial. Nutrients, 15(3), Article 565. https://doi.org/10.3390/nu15030565

There is interest in the impact that dietary interventions can have on preventing the transition from insulin resistance to type 2 diabetes, including a suggestion that the bioactive components of cocoa may enhance fasting insulin sensitivity. Howeve... Read More about Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial.

Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study (2023)
Journal Article
Horstman, A. M., Bawden, S. J., Spicer, A., Darwish, N., Goyer, A., Egli, L., …Simpson, E. J. (2023). Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study. American Journal of Clinical Nutrition, 117(4), 709-716. https://doi.org/10.1016/j.ajcnut.2023.01.014

Background: Owing to its role in glucose homeostasis, liver glycogen concentration ([LGly]) can be a marker of altered metabolism seen in disorders that impact the health of children. However, there is a paucity of normative data for this measure in... Read More about Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study.

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization (2022)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Chivaka, P. K., Constantin, D., Cordon, S. M., …Greenhaff, P. L. (2022). Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2999-3013. https://doi.org/10.1002/jcsm.13075

Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers... Read More about Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization.

Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study (2022)
Journal Article
Zhu, R., Jalo, E., Silvestre, M. P., Poppitt, S. D., Handjieva-Darlenska, T., Handjiev, S., …Raben, A. (2022). Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study. Diabetes Care, 45(11), 2698-2708. https://doi.org/10.2337/dc22-0549

OBJECTIVE: To examine whether the effect of a 3-year lifestyle intervention on body weight and cardiometabolic risk factors differs by prediabetes metabolic phenotype. RESEARCH DESIGN AND METHODS: This post hoc analysis of the multicenter, random... Read More about Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study.

Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW (2022)
Journal Article
Zhu, R., Craciun, I., Bernhards-Werge, J., Jalo, E., Poppitt, S. D., Silvestre, M. P., …Raben, A. (2022). Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW. Diabetologia, 65(8), 1262-1277. https://doi.org/10.1007/s00125-022-05716-3

Aims/hypothesis Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aime... Read More about Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW.

Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement (2022)
Journal Article
Mekjavic, I. B., Amon, M., Simpson, E. J., Kölegård, R., Eiken, O., & Macdonald, I. A. (2022). Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement. Frontiers in Physiology, 12, Article 801833. https://doi.org/10.3389/fphys.2021.801833

Due to the observations of weight loss at high altitude, normobaric hypoxia has been considered as a method of weight loss in obese individuals. With this regard, the aim of the present study was to determine the effect of hypoxia per se on metabolis... Read More about Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement.

Associations of quantity and quality of carbohydrate sources with subjective appetite sensations during 3-year weight-loss maintenance: Results from the PREVIEW intervention study (2021)
Journal Article
Zhu, R., Larsen, T. M., Poppitt, S. D., Silvestre, M. P., Fogelholm, M., Jalo, E., …Raben, A. (2022). Associations of quantity and quality of carbohydrate sources with subjective appetite sensations during 3-year weight-loss maintenance: Results from the PREVIEW intervention study. Clinical Nutrition, 41(1), 219-230. https://doi.org/10.1016/j.clnu.2021.11.038

Background & aims The association of quantity and quality of carbohydrate sources with appetite during long-term weight-loss maintenance (WLM) after intentional weight loss (WL) is unclear. We aimed to investigate longitudinal associations of quanti... Read More about Associations of quantity and quality of carbohydrate sources with subjective appetite sensations during 3-year weight-loss maintenance: Results from the PREVIEW intervention study.