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Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study

Zhu, Ruixin; Jalo, Elli; Silvestre, Marta P.; Poppitt, Sally D.; Handjieva-Darlenska, Teodora; Handjiev, Svetoslav; Huttunen-Lenz, Maija; Mackintosh, Kelly; Stratton, Gareth; Navas-Carretero, Santiago; Pietiläinen, Kirsi H.; Simpson, Elizabeth; Macdonald, Ian A.; Muirhead, Roslyn; Brand-Miller, Jennie; Fogelholm, Mikael; Færch, Kristine; Martinez, J. Alfredo; Westerterp-Plantenga, Margriet S.; Adam, Tanja C.; Raben, Anne


Ruixin Zhu

Elli Jalo

Marta P. Silvestre

Sally D. Poppitt

Teodora Handjieva-Darlenska

Svetoslav Handjiev

Maija Huttunen-Lenz

Kelly Mackintosh

Gareth Stratton

Santiago Navas-Carretero

Kirsi H. Pietiläinen

Elizabeth Simpson

Ian A. Macdonald

Roslyn Muirhead

Jennie Brand-Miller

Mikael Fogelholm

Kristine Færch

J. Alfredo Martinez

Margriet S. Westerterp-Plantenga

Tanja C. Adam

Anne Raben


OBJECTIVE: To examine whether the effect of a 3-year lifestyle intervention on body weight and cardiometabolic risk factors differs by prediabetes metabolic phenotype.

RESEARCH DESIGN AND METHODS: This post hoc analysis of the multicenter, randomized trial, PREVention of diabetes through lifestyle interventions and population studies In Europe and around the World (PREVIEW), included 1,510 participants with prediabetes (BMI ≥25 kg ⋅ m-2; defined using oral glucose tolerance tests). Of these, 58% had isolated impaired fasting glucose (iIFG), 6% had isolated impaired glucose tolerance (iIGT), and 36% had IFG+IGT; 73% had normal hemoglobin A1c (HbA1c; <39 mmol ⋅ mol-1) and 25% had intermediate HbA1c (39-47 mmol ⋅ mol-1). Participants underwent an 8-week diet-induced rapid weight loss, followed by a 148-week lifestyle-based weight maintenance intervention. Linear mixed models adjusted for intervention arm and other confounders were used.

RESULTS: In the available-case and complete-case analyses, participants with IFG+IGT had greater sustained weight loss after lifestyle intervention (adjusted mean at 156 weeks -3.5% [95% CI, -4.7%, -2.3%]) than those with iIFG (mean -2.5% [-3.6%, -1.3%]) relative to baseline (P = 0.011). Participants with IFG+IGT and iIFG had similar cardiometabolic benefits from the lifestyle intervention. The differences in cardiometabolic benefits between those with iIGT and IFG+IGT were minor or inconsistent in different analyses. Participants with normal versus intermediate HbA1c had similar weight loss over 3 years and minor differences in cardiometabolic benefits during weight loss, whereas those with normal HbA1c had greater improvements in fasting glucose, 2-h glucose (adjusted between-group difference at 156 weeks -0.54 mmol ⋅ L-1 [95% CI -0.70, -0.39], P < 0.001), and triglycerides (difference -0.07 mmol ⋅ L-1 [-0.11, -0.03], P < 0.001) during the lifestyle intervention.

CONCLUSIONS: Individuals with iIFG and IFG+IGT had similar improvements in cardiometabolic health from a lifestyle intervention. Those with normal HbA1c had greater improvements than those with intermediate HbA1c.


Zhu, R., Jalo, E., Silvestre, M. P., Poppitt, S. D., Handjieva-Darlenska, T., Handjiev, S., …Raben, A. (2022). Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study. Diabetes Care, 45(11), 2698-2708.

Journal Article Type Article
Acceptance Date Apr 25, 2022
Online Publication Date Jun 13, 2022
Publication Date 2022-11
Deposit Date Nov 25, 2022
Publicly Available Date Jan 26, 2023
Journal Diabetes Care
Print ISSN 0149-5992
Electronic ISSN 1935-5548
Peer Reviewed Peer Reviewed
Volume 45
Issue 11
Pages 2698-2708
Keywords Advanced and Specialized Nursing; Endocrinology, Diabetes and Metabolism; Internal Medicine
Public URL
Publisher URL


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