Outputs (41)

Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function (2020)
Journal Article
Atkins, R., Constantin-Teodosiu, D., Varadhan, K. K., Constantin, D., Lobo, D. N., & Greenhaff, P. L. (2021). Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function. Clinical Nutrition, 40(3), 1046-1051. https://doi.org/10.1016/j.clnu.2020.07.006

© 2020 The Author(s) Background & aims: This post hoc study aimed to determine whether major elective abdominal surgery had any acute impact on mitochondrial pyruvate dehydrogenase complex (PDC) activity and maximal mitochondrial ATP production rates... Read More about Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function.

Perioperative nutrition: Recommendations from the ESPEN expert group (2020)
Journal Article
Lobo, D. N., Gianotti, L., Adiamah, A., Barazzoni, R., Deutz, N., Dhatariya, K., …Weimann, A. (2020). Perioperative nutrition: Recommendations from the ESPEN expert group. Clinical Nutrition, 39(11), 3211-3227. https://doi.org/10.1016/j.clnu.2020.03.038

© 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Malnutrition has been recognized as a major risk factor for adverse postoperative outcomes. The ESPEN Symposium on perioperative nutrition was held in N... Read More about Perioperative nutrition: Recommendations from the ESPEN expert group.

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men (2019)
Journal Article
Gharahdaghi, N., Rudrappa, S., Brook, M. S., Idris, I., Crossland, H., Hamrock, C., …Atherton, P. J. (2019). Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men. Journal of Cachexia, Sarcopenia and Muscle, 10(6), 1276-1294. https://doi.org/10.1002/jcsm.12472

Background: The andropause is associated with declines in serum testosterone (T), loss of muscle mass (sarcopenia) and frailty. Two major interventions purported to offset sarcopenia are anabolic steroid therapies and resistance exercise training (RE... Read More about Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men.

Impact of transcutaneous neuromuscular electrical stimulation or resistance exercise on skeletal muscle mRNA expression in COPD (2019)
Journal Article
Latimer, L., Constantin, D., Greening, N., Calvert, L., Menon, M., & Greenhaff, P. (2019). Impact of transcutaneous neuromuscular electrical stimulation or resistance exercise on skeletal muscle mRNA expression in COPD. International Journal of Chronic Obstructive Pulmonary Disease, 14, 1355-1364. https://doi.org/10.2147/COPD.S189896

Background: Voluntary resistance exercise (RE) training increases muscle mass and strength in patients with chronic obstructive pulmonary disease (COPD). Nonvolitional transcutaneous neuromuscular electrical stimulation (NMES) may be an alternative s... Read More about Impact of transcutaneous neuromuscular electrical stimulation or resistance exercise on skeletal muscle mRNA expression in COPD.

Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans (2018)
Journal Article
Gaffney, C. J., Pollard, A., Barratt, T. F., Constantin-Teodosiu, D., Greenhaff, P. L., & Szewczyk, N. J. (2018). Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans. Aging, 10(11), 3382-3396. https://doi.org/10.18632/aging.101654

Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. C. elegans, a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here,... Read More about Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans.

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points (2018)
Journal Article
Crossland, H., Skirrow, S., Puthucheary, Z. A., Constantin-Teodosiu, D., & Greenhaff, P. L. (2018). The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points. Journal of Physiology, 597(5), 1259-1270. https://doi.org/10.1113/jp275444

Loss of muscle mass and insulin sensitivity are common phenotypic traits of immobilisation and increased inflammatory burden. The suppression of muscle protein synthesis is the primary driver of muscle mass loss in human immobilisation, and includes... Read More about The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points.

Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance (2018)
Journal Article
Handzlik, M., Constantin-Teodosiu, D., Greenhaff, P. L., & Cole, M. (2018). Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance. Journal of Physiology, 596(15), 3357-3369. https://doi.org/10.1113/JP275357

The pattern of metabolic reprogramming in chronic hypoxia shares similarities with that following myocardial infarction or hypertrophy, however the response of the chronically hypoxic heart to subsequent acute injury, and the role of metabolism is no... Read More about Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance.

Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake (2018)
Journal Article
Constantin-Teodosiu, D., Cederblad, G., Bergstrom, M., & Greenhaff, P. L. (2019). Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake. Clinical Nutrition, 38(2), 948-953. https://doi.org/10.1016/j.clnu.2018.02.001

© 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Exercise activates muscle pyruvate dehydrogenase complex (PDC), but moderate intensity exercise fails to fully activate muscle PDC after high-fat diet [... Read More about Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake.

Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery (2017)
Journal Article
Varadhan, K. K., Constantin-Teodosiu, D., Constantin, D., Greenhaff, P. L., & Lobo, D. N. (2017). Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery. Clinical Nutrition, 37(6, Part A), 2178-2185. https://doi.org/10.1016/j.clnu.2017.10.020

Background & aims: Postoperative hyperglycaemia is common in patients having major surgery and is associated with adverse outcomes. This study aimed to determine whether bacteraemia contributed to postoperative systemic inflammation, and whether incr... Read More about Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article
Mitchell, W. K., Phillips, B. E., Hill, I., Greenhaff, P. L., Lund, J. N., Williams, J. P., …Atherton, P. J. (2017). Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men. Clinical Science, 131(21), https://doi.org/10.1042/CS20171230

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.