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The Quest for Ecological Validity in Hearing Science: What It Is, Why It Matters, and How to Advance It (2020)
Journal Article
Keidser, G., Naylor, G., Brungart, D., Caduff, A., Campos, J., Carlile, S., …Smeds, K. (2020). The Quest for Ecological Validity in Hearing Science: What It Is, Why It Matters, and How to Advance It. Ear and Hearing, 41(Supplement 1), 5S-19S. https://doi.org/10.1097/AUD.0000000000000944

Ecological validity is a relatively new concept in hearing science. It has been cited as relevant with increasing frequency in publications over the past 20 years, but without any formal conceptual basis or clear motive. The sixth Eriksholm Workshop... Read More about The Quest for Ecological Validity in Hearing Science: What It Is, Why It Matters, and How to Advance It.

Biomedical engineering approaches to enhance therapeutic delivery for malignant glioma (2020)
Journal Article
McCrorie, P., Vasey, C. E., Smith, S. J., Marlow, M., Alexander, C., & Rahman, R. (2020). Biomedical engineering approaches to enhance therapeutic delivery for malignant glioma. Journal of Controlled Release, 328, 917-931. https://doi.org/10.1016/j.jconrel.2020.11.022

© 2020 We review the challenges of next-generation therapeutics for both systemic and localised delivery to brain tumours and discuss how recent engineering advances may be used to enhance brain penetration of systemic delivery therapies. The unmet c... Read More about Biomedical engineering approaches to enhance therapeutic delivery for malignant glioma.

Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis (2020)
Journal Article
Meng, D., Welton, T., Elsarraj, A., Morgan, P. S., das Nair, R., Constantinescu, C. S., …Dineen, R. A. (2020). Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis. Human Brain Mapping, 42(2), 495-509. https://doi.org/10.1002/hbm.25239

Three decades ago a series of parallel circuits were described involving the frontal cortex and deep grey matter structures, with putative roles in control of motor and oculomotor function, cognition, behaviour and emotion. The circuit comprising the... Read More about Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis.

Fasting and surgery timing (FaST) audit (2020)
Journal Article
El-Sharkawy, A. M., Daliya, P., Lewis-Lloyd, C., Adiamah, A., Malcolm, F. L., Boyd-Carson, H., …Wolff, J. (2021). Fasting and surgery timing (FaST) audit. Clinical Nutrition, 40(3), 1405-1412. https://doi.org/10.1016/j.clnu.2020.08.033

Background & aims

International guidance advocates the avoidance of prolonged preoperative fasting due to its negative impact on perioperative hydration. This study aimed to assess the adherence to these guidelines for fasting in patients undergoi... Read More about Fasting and surgery timing (FaST) audit.

Insights into conducting audiological research with clinical databases (2020)
Journal Article
Dillard, L. K., Saunders, G. H., Zobay, O., & Naylor, G. (2020). Insights into conducting audiological research with clinical databases. American Journal of Audiology, 29(3S), 676-681. https://doi.org/10.1044/2020_AJA-19-00067

The clinical data stored in electronic health records (EHRs) provide unique opportunities for audiological clinical research. In this viewpoint article, we share insights from our experience of working with a large clinical database of over 730,00... Read More about Insights into conducting audiological research with clinical databases.

Effect of short-term integrated palliative care on patient-reported outcomes among people with advanced long-term neurological conditions : A randomized clinical trial (2020)
Journal Article
Gao, W., Wilson, R., Hepgul, N., Yi, D., Evans, C., Bajwah, S., …Higginson, I. J. (2020). Effect of short-term integrated palliative care on patient-reported outcomes among people with advanced long-term neurological conditions : A randomized clinical trial. JAMA Network Open, 3(8), Article e2015061. https://doi.org/10.1001/jamanetworkopen.2020.15061

Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier (2020)
Journal Article
Alelwani, W., Elmorsy, E., Kattan, S. W., Babteen, N. A., Alnajeebi, A. M., Al-Ghafari, A., & Carter, W. G. (2020). Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier. Toxicology Letters, 333, 184-191. https://doi.org/10.1016/j.toxlet.2020.08.006

Carbamazepine (CBZ) is a widely employed anti-seizure medication that crosses the blood-brain barrier (BBB) to exert its anti-convulsant action. The effects of CBZ on components of the BBB have yet to be completely delineated. Hence the current study... Read More about Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier.

Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets (2020)
Journal Article
Kurozumi, S., Alsaleem, M., Monteiro, C. J., Bhardwaj, K., Joosten, S. E., Fujii, T., …Johnston, S. J. (2020). Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets. Breast Cancer Research, 22, Article 85. https://doi.org/10.1186/s13058-020-01324-4

© 2020 The Author(s). Background: Invasive lobular carcinoma (ILC) accounts for 10-15% of primary breast cancers and is typically estrogen receptor alpha positive (ER+) and ERBB2 non-amplified. Somatic mutations in ERBB2/3 are emerging as a tractable... Read More about Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.