Outputs (138)

Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens (2020)
Journal Article
Vallières, C., Singh, N., Alexander, C., & Avery, S. V. (2020). Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens. ACS Infectious Diseases, 6(11), 2950-2958. https://doi.org/10.1021/acsinfecdis.0c00405

With the spread of drug resistance, new antimicrobials are urgently needed. Here, we set out to tackle this problem by high-throughput exploration for novel antifungal synergies among combinations of approved, nonantifungal drugs; a novel strategy ex... Read More about Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens.

Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation (2020)
Journal Article
Cooper, A. H., Hanmer, J. M., Chapman, V., & Hathway, G. J. (2020). Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation. PAIN Reports, 5(6), Article e872. https://doi.org/10.1097/PR9.0000000000000872

Introduction: Inflammation during the neonatal period can exacerbate pain severity following reinjury in adulthood. This is driven by alterations in the postnatal development of spinal and supraspinal nociceptive circuitry. However, the contribution... Read More about Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation.

Global sexual fertility in the opportunistic pathogen aspergillus fumigatus and identification of new supermater strains (2020)
Journal Article
Swilaiman, S. S., O’Gorman, C. M., Du, W., Sugui, J. A., Del Buono, J., Brock, M., Kwon-Chung, K. J., Szakacs, G., & Dyer, P. S. (2020). Global sexual fertility in the opportunistic pathogen aspergillus fumigatus and identification of new supermater strains. Journal of Fungi, 6(4), Article 258. https://doi.org/10.3390/jof6040258

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. A sexual cycle in Aspergillus fumigatus was first described in 2009 with isolates from Dublin, Ireland. However, the extent to which worldwide isolates can undergo sexual reproduction has rema... Read More about Global sexual fertility in the opportunistic pathogen aspergillus fumigatus and identification of new supermater strains.

CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes (2020)
Journal Article
Kondrashov, A., Mohd Yusof, N. A., Hasan, A., Goulding, J., Kodagoda, T., Hoang, D. M., Vo, N. T., Melarangi, T., Dolatshad, N., Gorelik, J., Hill, S. J., Harding, S. E., & Denning, C. (2021). CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes. Molecular Therapy - Methods and Clinical Development, 20, 39-53. https://doi.org/10.1016/j.omtm.2020.10.019

© 2020 During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β2AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association... Read More about CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes.

Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies (2020)
Journal Article
Kilpatrick, L. E., & Hill, S. J. (2021). Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies. Current Opinion in Endocrine and Metabolic Research, 16, 102-112. https://doi.org/10.1016/j.coemr.2020.10.003

© 2020 The Authors Alterations in signalling due to bidirectional transactivation of G protein-coupled receptor (GPCRs) and receptor tyrosine kinases (RTKs) are well established. Transactivation significantly diversifies signalling networks within a... Read More about Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies.

Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites (2020)
Journal Article
Zeeshan, M., Brady, D., Stanway, R. R., Moores, C., Holder, A. A., & Tewari, R. (2020). Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites. Frontiers in Cellular and Infection Microbiology, 10, Article 583812. https://doi.org/10.3389/fcimb.2020.583812

© Copyright © 2020 Zeeshan, Brady, Stanway, Moores, Holder and Tewari. Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for prope... Read More about Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites.

The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review (2020)
Journal Article
Williams, M., Todd, I., & Fairclough, L. C. (2020). The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review. Inflammation Research, https://doi.org/10.1007/s00011-020-01408-z

© 2020, The Author(s). Objective and design: This systematic review aims to establish the role of CD8 + T lymphocytes in COPD. Methods: Forty-eight papers published in the last 15years were identified for inclusion. Results: CD8 + T-cells are increas... Read More about The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review.

Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression (2020)
Journal Article
Villota, S. D., Toledo-Rodriguez, M., & Leach, L. (2021). Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression. Diabetologia, 64, 195-210. https://doi.org/10.1007/s00125-020-05290-6

© 2020, The Author(s). Aims/hypothesis: Reduced occupancy of junctional occludin is a feature of human placental vessels in the diabetic milieu. However, the functional consequence of this and whether this loss is due to differential expression of oc... Read More about Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression.

Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments (2020)
Journal Article
Harvey, H. J., Wildman, R. D., Mooney, S. J., & Avery, S. V. (2020). Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments. Computational and Structural Biotechnology Journal, 18, 2860-2866. https://doi.org/10.1016/j.csbj.2020.09.030

© 2020 The Author(s) Spatial structure over scales ranging from nanometres to centimetres (and beyond) varies markedly in diverse habitats and the industry-relevant settings that support microbial activity. Developing an understanding of the interpla... Read More about Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments.

Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age (2020)
Journal Article
Sayda, M. H., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2020). Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age. Nutrients, 12(10), Article 3029. https://doi.org/10.3390/nu12103029

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support and regulation of tissue protein regulation and also as energy substrates. However, p... Read More about Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age.