Outputs (138)

Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome (2018)
Journal Article
Blount, B. A., Gowers, G.-O. F., Ho, J. C. H., Ledesma-Amaro, R., Jovicevic, D., McKiernan, R. M., Xie, Z. X., Li, B. Z., Yuan, Y. J., & Ellis, T. (2018). Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome. Nature Communications, 9(1), Article 1932. https://doi.org/10.1038/s41467-018-03143-w

© 2018 The Author(s). Synthetic biology tools, such as modular parts and combinatorial DNA assembly, are routinely used to optimise the productivity of heterologous metabolic pathways for biosynthesis or substrate utilisation, yet it is well establis... Read More about Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome.

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle (2018)
Journal Article
Perrin, L., Loizides-Mangold, U., Chanon, S., Gobet, C., Hulo, N., Isenegger, L., Weger, B. D. .., Migliavacca, E., Charpagne, A., Betts, J. A., Walhin, J.-P., Templeman, I., Stokes, K., Thompson, D., Tsintzas, K., Robert, M., Howald, C., Riezman, H., Feige, J. N., Karagounis, L. G., …Dibner, C. (2018). Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle. eLife, 7, Article e34114. https://doi.org/10.7554/elife.34114.001

Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchro... Read More about Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle.

Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites (2018)
Journal Article
Luderman, K. D., Conroy, J. L., Free, R. B., Southall, N., Ferrer, M., Sanchez-Soto, M., Moritz, A. E., Willette, B. K. A., Fyfe, T. J., Jain, P., Titus, S., Hazelwood, L. A., Aubé, J., Lane, J. R., Frankowski, K. J., & Sibley, D. R. (2018). Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites. Molecular Pharmacology, 94(4), 1197-1209. https://doi.org/10.1124/mol.118.113175

The D1 dopamine receptor is linked to a variety of neuropsychiatric disorders and represents an attractive drug target for the enhancement of cognition in schizophrenia, Alzheimer disease, and other disorders. Positive allosteric modulators (PAMs), w... Read More about Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018)
Journal Article
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., Blagosklonny, M. V., …Kroemer, G. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25(3), 486-541. https://doi.org/10.1038/s41418-017-0012-4

Technical challenges of working with extracellular vesicles (2017)
Journal Article
Ramirez, M. I., Amorim, M. G., Gadelha, C., Milic, I., Welsh, J. A., Freitas, V. M., Nawaz, M., Akbar, N., Couch, Y., Makin, L., Cooke, F., Vettore, A. L., Batista, P. X., Freezor, R., Pezuk, J. A., Rosa-Fernandes, L., Carreira, A. C. O., Devitt, A., Jacobs, L., Silva, I. T., …Dias-Neto, E. (2018). Technical challenges of working with extracellular vesicles. Nanoscale, 10(3), 881-906. https://doi.org/10.1039/c7nr08360b

© 2018 The Royal Society of Chemistry. Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nanosi... Read More about Technical challenges of working with extracellular vesicles.

Photoinhibition of FeFe hydrogenase (2017)
Journal Article
Sensi, M., Baffert, C., Fradale, L., Gauquelin, C., Soucaille, P., Meynial-Salles, I., Bottin, H., De Gioia, L., Bruschi, M., Fourmond, V., Léger, C., & Bertini, L. (2017). Photoinhibition of FeFe hydrogenase. ACS Catalysis, 7(10), 7378-7387. https://doi.org/10.1021/acscatal.7b02252

© 2017 American Chemical Society. In the enzyme FeFe hydrogenase, hydrogen oxidation and production occur at the H-cluster, a Fe6S6 active site that bears intrinsic carbonyl and cyanide ligands. This enzyme has been coupled to photosensitizers to des... Read More about Photoinhibition of FeFe hydrogenase.

A kinetic view of GPCR allostery and biased agonism (2017)
Journal Article
Lane, J. R., May, L. T., Parton, R. G., Sexton, P. M., & Christopoulos, A. (2017). A kinetic view of GPCR allostery and biased agonism. Nature Chemical Biology, 13(9), 929-937. https://doi.org/10.1038/nchembio.2431

The genomic mosaicism of hybrid speciation (2017)
Journal Article
Elgvin, T. O., Trier, C. N., Tørresen, O. K., Hagen, I. J., Lien, S., Nederbragt, A. J., Ravinet, M., Jensen, H., & Sætre, G. P. (2017). The genomic mosaicism of hybrid speciation. Science Advances, 3(6), Article e1602996. https://doi.org/10.1126/sciadv.1602996

Copyright © 2017 The Authors, some rights reserved. Hybridization is widespread in nature and, in some instances, can result in the formation of a new hybrid species. We investigate the genetic foundation of this poorly understood process through who... Read More about The genomic mosaicism of hybrid speciation.

Contrasting effects of environment and genetics generate a continuum of parallel evolution (2017)
Journal Article
Stuart, Y. E., Veen, T., Weber, J. N., Hanson, D., Ravinet, M., Lohman, B. K., Thompson, C. J., Tasneem, T., Doggett, A., Izen, R., Ahmed, N., Barrett, R. D. H., Hendry, A. P., Peichel, C. L., & Bolnick, D. I. (2017). Contrasting effects of environment and genetics generate a continuum of parallel evolution. Nature Ecology and Evolution, 1(6), Article 0158. https://doi.org/10.1038/s41559-017-0158

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Parallel evolution of similar traits by independent populations in similar environments is considered strong evidence for adaptation by natural selection. Often, howev... Read More about Contrasting effects of environment and genetics generate a continuum of parallel evolution.

Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast (2017)
Journal Article
Awan, A. R., Blount, B. A., Bell, D. J., Shaw, W. M., Ho, J. C., McKiernan, R. M., & Ellis, T. (2017). Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast. Nature Communications, 8, Article 15202. https://doi.org/10.1038/ncomms15202

© The Author(s) 2017. Fungi are a valuable source of enzymatic diversity and therapeutic natural products including antibiotics. Here we engineer the baker’s yeast Saccharomyces cerevisiae to produce and secrete the antibiotic penicillin, a beta-lact... Read More about Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast.