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Outputs (138)

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage (2021)
Journal Article
Zhu, Q., Sang, F., Withey, S., Tang, W., Dietmann, S., Klisch, D., Ramos-Ibeas, P., Zhang, H., Requena, C. E., Loose, M., Surani, M. A., & Alberio, R. (2021). Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage. Cell Reports, 34(6), Article 108735. https://doi.org/10.1016/j.celrep.2021.108735

Investigations of the human germline and programming are challenging because of limited access to embryonic material. However, the pig as a model may provide insights into transcriptional network and epigenetic reprogramming applicable to both specie... Read More about Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage.

Time or place? Dissociation between object-in-place and relative recency in young APPswe/PS1dE9 mice. (2021)
Journal Article
Bonardi, C., Pardon, M.-C., & Armstrong, P. (2021). Time or place? Dissociation between object-in-place and relative recency in young APPswe/PS1dE9 mice. Behavioral Neuroscience, 135(1), 39-50. https://doi.org/10.1037/bne0000431

This study tests the predictions of a novel analysis of recognition memory based on a theory of associative learning, according to which recognition comprises two independent underlying processes, one relying on the to-be-recognized item having been... Read More about Time or place? Dissociation between object-in-place and relative recency in young APPswe/PS1dE9 mice..

Molecular phylogeny of the orthurethra (panpulmonata: Stylommatophora) (2021)
Journal Article
Saadi, A. J., Mordan, P. B., & Wade, C. M. (2021). Molecular phylogeny of the orthurethra (panpulmonata: Stylommatophora). Zoological Journal of the Linnean Society, 193(3), 1126-1140. https://doi.org/10.1093/zoolinnean/zlaa168

We have undertaken a molecular analysis of the Orthurethra, one of the major groups of stylommatophoran land snails and slugs. Approximately 4000 nucleotides of the rRNA gene cluster [5.8S, internal transcribed spacer 2 (ITS2) and almost the full-len... Read More about Molecular phylogeny of the orthurethra (panpulmonata: Stylommatophora).

A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes (2020)
Journal Article
Ramzan, I., Taylor, M., Phillips, B., Wilkinson, D., Smith, K., Hession, K., Idris, I., & Atherton, P. (2021). A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes. Nutrients, 13(1), Article 95. https://doi.org/10.3390/nu13010095

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Elevated circulating branched-chain amino acids (BCAAs; isoleucine, leucine, and valine) are associated with obesity and type 2 diabetes (T2D). Reducing circulatory BCAAs by dietary restrictio... Read More about A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes.

The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo (2020)
Journal Article
Bass, J. J., Kazi, A. A., Deane, C. S., Nakhuda, A., Ashcroft, S. P., Brook, M. S., Wilkinson, D. J., Phillips, B. E., Philp, A., Tarum, J., Kadi, F., Andersen, D., Garcia, A. M., Smith, K., Gallagher, I. J., Szewczyk, N. J., Cleasby, M. E., & Atherton, P. J. (2021). The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo. Journal of Physiology, 599(3), 963-979. https://doi.org/10.1113/JP280652

Key points: Reduced vitamin D receptor (VDR) expression prompts skeletal muscle atrophy. Atrophy occurs through catabolic processes, namely the induction of autophagy, while anabolism remains unchanged. In response to VDR-knockdown mitochondrial func... Read More about The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo.

Stat3 oxidation-dependent regulation of gene expression impacts on developmental processes and involves cooperation with Hif-1α (2020)
Journal Article
Grillo, M., Palmer, C., Holmes, N., Sang, F., Larner, A. C., Bhosale, R., & Shaw, P. E. (2020). Stat3 oxidation-dependent regulation of gene expression impacts on developmental processes and involves cooperation with Hif-1α. PLoS ONE, 15(12), Article e0244255. https://doi.org/10.1371/journal.pone.0244255

© 2020 Grillo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Stat3 oxidation-dependent regulation of gene expression impacts on developmental processes and involves cooperation with Hif-1α.

Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells (2020)
Journal Article
Stoddart, L. A., Kindon, N. D., Otun, O., Harwood, C. R., Patera, F., Veprintsev, D. B., Woolard, J., Briddon, S. J., Franks, H. A., Hill, S. J., & Kellam, B. (2020). Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells. Communications Biology, 3(1), Article 722. https://doi.org/10.1038/s42003-020-01451-w

© 2020, The Author(s). To study the localisation of G protein-coupled receptors (GPCR) in their native cellular environment requires their visualisation through fluorescent labelling. To overcome the requirement for genetic modification of the recept... Read More about Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells.

The Sustainable Path to a Circular Bioeconomy (2020)
Journal Article
Hadley Kershaw, E., Hartley, S., Mcleod, C., & Polson, P. (2021). The Sustainable Path to a Circular Bioeconomy. Trends in Biotechnology, 39(6), 542-545. https://doi.org/10.1016/j.tibtech.2020.10.015

Circular bioeconomy is gaining prominence in academic, policy, and industry contexts, linking circular economy and bioeconomy agendas in service of sustainability. However, it is at risk of developing in narrow, unsustainable ways. A sustainable path... Read More about The Sustainable Path to a Circular Bioeconomy.

Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock (2020)
Journal Article
Ralevic, V. (2021). Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock. Purinergic Signalling, 17, 63-69. https://doi.org/10.1007/s11302-020-09734-x

© 2020, The Author(s). Geoffrey Burnstock made groundbreaking discoveries on the physiological roles of purinergic receptors and led on P2 purinergic receptor classification. His knowledge, vision and leadership inspired and influenced the internatio... Read More about Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock.