Time or place? Dissociation between object-in-place and relative recency in young APPswe/PS1dE9 mice.

Bonardi, Charlotte; Pardon, Marie-Christine; Armstrong, Paul

Abstract

This study tests the predictions of a novel analysis of recognition memory based on a theory of associative learning, according to which recognition comprises two independent underlying processes, one relying on the to-be-recognized item having been experienced recently (self-generated priming), and the other on it being predicted by some other stimulus (retrieval-generated priming). A single experiment examined recognition performance in the amyloid precursor protein (APP)swe/PS1dE9 (APP/PS1) mouse, a double-transgenic model of Alzheimer's disease (AD), and wild type (WT) littermates. Performance on two variants of the spontaneous object recognition (SOR) was compared in 5-month-old APPswe/PS1dE9 (APP/PS1) mice, a double-transgenic model of AD, and their WT littermates, using junk objects. In the relative recency task animals were exposed to object A, and then object B, followed by a test with both A and B. In the object-in-place task the mice were exposed to both A and B, and then tested with two copies of A, occupying the same positions as the preeexposed objects. The WT mice showed a preference for exploring the first-presented object A in the relative recency task, and the copy of A in the "wrong" position (i.e., the one placed where B had been during the preexposure phase) in the object-in-place task. The APP/PS1 mice performed like the WT mice in the relative recency task, but showed a selective impairment in the object-in-place task. We interpret these findings in terms of-Wagner's (Information processing in animals: Memory Mechanisms, 1981, Erlbaum) theory of associative learning, sometimes opponent process (SOP), as a selective deficit in retrieval-generated priming.

• Journal Article Type: Article
• Acceptance Date: Oct 27, 2020
• Online Publication Date: Feb 1, 2021
• Publication Date: Feb 1, 2021
• Deposit Date: Oct 28, 2020
• Publicly Available Date: Feb 1, 2021
• Journal: Behavioral Neuroscience
• Print ISSN: 0735-7044
• Electronic ISSN: 1939-0084
• Publisher: American Psychological Association
• Peer Reviewed: Peer Reviewed
• Volume: 135
• Issue: 1
• Pages: 39-50
• DOI: https://doi.org/10.1037/bne0000431
• Keywords: Behavioral Neuroscience
• Public URL: https://nottingham-repository.worktribe.com/output/4996191
• Publisher URL: https://content.apa.org/record/2021-35829-005
• Additional Information: ©American Psychological Association, 2021. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. Please do not copy or cite without author's permission. The final article is available, upon publication, at: https://content.apa.org/doi/10.1037/bne0000431