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SBRC-Nottingham: sustainable routes to platform chemicals from C1 wastes Gases (2016)
Journal Article
Burbidge, A., & Minton, N. P. (2016). SBRC-Nottingham: sustainable routes to platform chemicals from C1 wastes Gases. Biochemical Society Transactions, 44(3), (684-686). doi:10.1042/BST20160010. ISSN 0300-5127

SBRC-Nottingham (www.sbrc-nottingham.ac.uk) was one of the first three UK university-based Synthetic Biology Research Centres (SBRCs) to be funded by the BBSRC and EPSRC as part of the recommendations made in the UKs Synthetic Biology Roadmap. It was... Read More about SBRC-Nottingham: sustainable routes to platform chemicals from C1 wastes Gases.

The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study (2006)
Journal Article
Zachariou, M., Dissanayake, D., Owen, M. R., Mason, R., & Coombes, S. The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study. Neurocomputing, 70(10/12), doi:10.1016/j.neucom.2006.10.065

Gating of sensory (e.g. auditory) information has been demonstrated as a reduction in the auditory-evoked potential responses recorded in the brain of both normal animals and human subjects. Auditory gating is perturbed in schizophrenic patients and... Read More about The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study.

Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis (2008)
Journal Article
Zachariou, M., Dissanayake, D. W. N., Coombes, S., Owen, M. R., & Mason, R. (in press). Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis. Cognitive Neurodynamics, 2, doi:10.1007/s11571-008-9050-4

Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific... Read More about Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis.

The transposon-like correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus (2011)
Journal Article
Siddique, A., Buisine, N., & Chalmers, R. (2011). The transposon-like correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus. PLoS Genetics, 7(1), doi:10.1371/journal.pgen.1001277

Neisseria meningitidis is the primary causative agent of bacterial meningitis. The genome is rich in repetitive DNA and almost 2% is occupied by a diminutive transposon called the Correia element. Here we report a bioinformatic analysis defining eigh... Read More about The transposon-like correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus.

H-NS mediates the dissociation of a refractory protein–DNA complex during Tn10/IS10 transposition (2011)
Journal Article
Liu, D., Haniford, D. B., & Chalmers, R. (2011). H-NS mediates the dissociation of a refractory protein–DNA complex during Tn10/IS10 transposition. Nucleic Acids Research, 39(15), doi:10.1093/nar/gkr309

Tn10/IS10 transposition takes place in the context of a protein–DNA complex called a transpososome. During the reaction, the transpososome undergoes several conformational changes. The host proteins IHF and H-NS, which also are global regulators of g... Read More about H-NS mediates the dissociation of a refractory protein–DNA complex during Tn10/IS10 transposition.

Base flipping in Tn10 transposition: an active flip and capture mechanism (2009)
Journal Article
Bischerour, J., & Chalmers, R. (2009). Base flipping in Tn10 transposition: an active flip and capture mechanism. PLoS ONE, 4(7), doi:10.1371/journal.pone.0006201

The bacterial Tn5 and Tn10 transposases have a single active site that cuts both strands of DNA at their respective transposon ends. This is achieved using a hairpin intermediate that requires the DNA to change conformation during the reaction. In Tn... Read More about Base flipping in Tn10 transposition: an active flip and capture mechanism.

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ (2011)
Journal Article
Begitt, A., Droescher, M., Knobeloch, K., & Vinkemeier, U. (2011). SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ. Blood, 118(4), doi:10.1182/blood-2011-04-347930

The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation. This occurs both directly through decreasing STAT1 tyrosine phosphorylation and indir... Read More about SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.

Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart (2011)
Journal Article
Rutland, C. S., Polo-Parada, L., Ehler, E., Alibhai, A., Thorpe, A., Suren, S., …Loughna, S. (2011). Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart. Development, 138(18), doi:10.1242/dev.059063

The expression and function of embryonic myosin heavy chain (eMYH) has not been investigated within the early developing heart. This is despite the knowledge that other structural proteins, such as alpha and beta myosin heavy chains and cardiac alpha... Read More about Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart.

Dimerization of ABCG2 analysed by bimolecular fluorescence complementation (2011)
Journal Article
Haider, A. J., Briggs, D., Self, T. J., Chilvers, H. L., Holliday, N. D., & Kerr, I. D. (2011). Dimerization of ABCG2 analysed by bimolecular fluorescence complementation. PLoS ONE, 6(10), doi:10.1371/journal.pone.0025818

ABCG2 is one of three human ATP binding cassette transporters that are functionally capable of exporting a diverse range of substrates from cells. The physiological consequence of ABCG2 multidrug transport activity in leukaemia, and some solid tumour... Read More about Dimerization of ABCG2 analysed by bimolecular fluorescence complementation.