Outputs (85)

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ (2011)
Journal Article
Begitt, A., Droescher, M., Knobeloch, K.-P., & Vinkemeier, U. (2011). SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ. Blood, 118(4), https://doi.org/10.1182/blood-2011-04-347930

The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation. This occurs both directly through decreasing STAT1 tyrosine phosphorylation and indir... Read More about SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.

STAT1 signaling is not regulated by a phosphorylation-acetylation switch (2011)
Journal Article
Antunes, F., Marg, A., & Vinkemeier, U. (2011). STAT1 signaling is not regulated by a phosphorylation-acetylation switch. Molecular and Cellular Biology, 31(14), https://doi.org/10.1128/MCB.05300-11

The treatment of cells with histone deacetylase inhibitors (HDACi) was reported to reveal the acetylation of
STAT1 at lysine 410 and lysine 413 (O. H. Kra¨mer et al., Genes Dev. 20:473–485, 2006). STAT1 acetylation was
proposed to regulate apoptosi... Read More about STAT1 signaling is not regulated by a phosphorylation-acetylation switch.

H-NS mediates the dissociation of a refractory protein–DNA complex during Tn10/IS10 transposition (2011)
Journal Article
Liu, D., Haniford, D. B., & Chalmers, R. (2011). H-NS mediates the dissociation of a refractory protein–DNA complex during Tn10/IS10 transposition. Nucleic Acids Research, 39(15), https://doi.org/10.1093/nar/gkr309

Tn10/IS10 transposition takes place in the context of a protein–DNA complex called a transpososome. During the reaction, the transpososome undergoes several conformational changes. The host proteins IHF and H-NS, which also are global regulators of g... Read More about H-NS mediates the dissociation of a refractory protein–DNA complex during Tn10/IS10 transposition.

Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling (2011)
Journal Article
Baker, J. G., Hill, S. J., & Summers, R. J. (2011). Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends in Pharmacological Sciences, 32(4), https://doi.org/10.1016/j.tips.2011.02.010

Sir James Black developed β-blockers, one of the most useful groups of drugs in use today. Not only are they being used for their original purpose to treat angina and cardiac arrhythmias, but they are also effective therapeutics for hypertension, car... Read More about Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling.

The transposon-like correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus (2011)
Journal Article
Siddique, A., Buisine, N., & Chalmers, R. (2011). The transposon-like correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus. PLoS Genetics, 7(1), Article 13. https://doi.org/10.1371/journal.pgen.1001277

Neisseria meningitidis is the primary causative agent of bacterial meningitis. The genome is rich in repetitive DNA and almost 2% is occupied by a diminutive transposon called the Correia element. Here we report a bioinformatic analysis defining eigh... Read More about The transposon-like correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus.

Nuclear survivin: cellular consequences and therapeutic implications (2011)
Book Chapter
Wheatley, S. P. (2011). Nuclear survivin: cellular consequences and therapeutic implications. In H. Gali-Muhtasib (Ed.), Advances in cancer therapy. InTech. https://doi.org/10.5772/24795

The great deluge algorithm explores neighbouring solutions which are accepted if they are better than the best solution so far or if the detriment in quality is no larger than the current water level. In the original great deluge method, the water le... Read More about Nuclear survivin: cellular consequences and therapeutic implications.

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain (2010)
Journal Article
Sagar, D. R., Staniaszek, L. E., Okine, B. N., Woodhams, S., Norris, L. M., Pearson, R. G., Garle, M. J., Alexander, S. P., Bennett, A. J., Barrett, D. A., Kendall, D. A., Scammell, B. E., & Chapman, V. (2010). Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Arthritis and Rheumatism, 62(12), https://doi.org/10.1002/art.27698

Objective. To investigate the impact of an experimental
model of osteoarthritis (OA) on spinal nociceptive
processing and the role of the inhibitory endocannabinoid
system in regulating sensory processing at the
spinal level.
Methods. Experiment... Read More about Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain.

Base flipping in Tn10 transposition: an active flip and capture mechanism (2009)
Journal Article
Bischerour, J., & Chalmers, R. (2009). Base flipping in Tn10 transposition: an active flip and capture mechanism. PLoS ONE, 4(7), Article e6201. https://doi.org/10.1371/journal.pone.0006201

The bacterial Tn5 and Tn10 transposases have a single active site that cuts both strands of DNA at their respective transposon ends. This is achieved using a hairpin intermediate that requires the DNA to change conformation during the reaction. In Tn... Read More about Base flipping in Tn10 transposition: an active flip and capture mechanism.

Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis (2008)
Journal Article
Zachariou, M., Dissanayake, D. W. N., Coombes, S., Owen, M. R., & Mason, R. (in press). Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis. Cognitive Neurodynamics, 2, https://doi.org/10.1007/s11571-008-9050-4

Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific... Read More about Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis.

Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells (2007)
Journal Article
van Leeuwen, I. M. M., Byrne, H. M., Jensen, O. E., & King, J. R. (2007). Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells. Journal of Theoretical Biology, 247(1), 77-102. https://doi.org/10.1016/j.jtbi.2007.01.019

Wnt signalling is involved in a wide range of physiological and pathological processes. The presence of an extracellular Wnt stimulus induces cytoplasmic stabilisation and nuclear translocation of beta-catenin, a protein that also plays an essential... Read More about Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells.