Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes (2019)
Journal Article
Izquierdo, A., Fahrenberger, M., Persampieri, T., Benedict, M. Q., Giles, T., Catteruccia, F., …Dottorini, T. (2019). Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes. Life Science Alliance, 2(1), Article e00191. https://doi.org/10.26508/lsa.201800191

Modifications in gene expression determine many of the phenotypic differentiations between closely related species. This is particularly evident in reproductive tissues, where evolution of genes is more rapid, facilitating the appearance of distinct... Read More about Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes.

Engaging and developing the frontline clinical nurse to drive care excellence: evaluating the Chief Nurse Junior Excellence in Care Fellowship Initiative (2018)
Journal Article
Bramley, L., Manning, J., & Cooper, J. (2018). Engaging and developing the frontline clinical nurse to drive care excellence: evaluating the Chief Nurse Junior Excellence in Care Fellowship Initiative. International Journal of Research in Nursing, 16(12), 1977-1990. https://doi.org/10.1177/1744987118808843

Background

Global challenges in the development of a highly skilled and motivated nursing workforce, jeopardises the delivery of high quality care. Flexible and innovative workforce solutions are required to overcome these challenges.

Aims... Read More about Engaging and developing the frontline clinical nurse to drive care excellence: evaluating the Chief Nurse Junior Excellence in Care Fellowship Initiative.

Parents’ and carers’ experiences of transition and aftercare following a child’s discharge from a paediatric intensive care unit to an in-patient ward setting: A qualitative systematic review (2018)
Journal Article
Suleman, Z., Evans, C., & Manning, J. (2019). Parents’ and carers’ experiences of transition and aftercare following a child’s discharge from a paediatric intensive care unit to an in-patient ward setting: A qualitative systematic review. Intensive and Critical Care Nursing, 51, 35-44. https://doi.org/10.1016/j.iccn.2018.10.003

Objectives: To explore parents’ experiences of transition and aftercare following their child’s discharge from a pediatric intensive care unit to an inpatient ward.
Methods: A qualitative systematic review was conducted. Electronic databases CINAHL,... Read More about Parents’ and carers’ experiences of transition and aftercare following a child’s discharge from a paediatric intensive care unit to an in-patient ward setting: A qualitative systematic review.

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists (2018)
Journal Article
Adlere, I., Sun, S., Zarca, A., Roumen, L., Gozelle, M., Viciano, C. P., …Leurs, R. (2019). Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists. European Journal of Medicinal Chemistry, 162, 631-649. https://doi.org/10.1016/j.ejmech.2018.10.060

Using the available structural information of the chemokine receptor CXCR4, we present hit finding and hit exploration studies that make use of virtual fragment screening, design, synthesis and structure-activity relationship (SAR) studies. Fragment... Read More about Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.

Cortical correlates of speech intelligibility measured using functional near-infrared spectroscopy (fNIRS) (2018)
Journal Article
Lawrence, R. J., Wiggins, I. M., Anderson, C. A., Davies-Thompson, J., & Hartley, D. E. (2018). Cortical correlates of speech intelligibility measured using functional near-infrared spectroscopy (fNIRS). Hearing Research, 370, 53-64. https://doi.org/10.1016/j.heares.2018.09.005

Functional neuroimaging has identified that the temporal, frontal and parietal cortex support core aspects of speech processing. An objective measure of speech intelligibility based on cortical activation in these brain regions would be extremely use... Read More about Cortical correlates of speech intelligibility measured using functional near-infrared spectroscopy (fNIRS).

Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis (2018)
Journal Article
Mbanefo, E. C., Le, L., Pennington, L. F., Odegaard, J. I., Jardetzky, T. S., Alouffi, A., …Hsieh, M. H. (2018). Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis. FASEB Journal, 32(8), 4408-4419. https://doi.org/10.1096/fj.201701415r

Chemotherapy-induced hemorrhagic cystitis (CHC) can be difficult to manage. Prior work suggests that IL-4 alleviates ifosfamide-induced hemorrhagic cystitis (IHC), but systemically administered IL-4 causes significant side effects. We hypothesized th... Read More about Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis.

Proportionate methods for evaluating a simple digital mental health tool (2017)
Journal Article
Davies, E. B., Craven, M. P., Martin, J. L., & Simons, L. (2017). Proportionate methods for evaluating a simple digital mental health tool. Evidence-Based Mental Health, 20(4), 112-117. https://doi.org/10.1136/eb-2017-102755

Background: Traditional evaluation methods are not keeping pace with rapid developments in mobile health. More flexible methodologies are needed to evaluate mHealth technologies, particularly simple, self-help tools. One approach is to combine a var... Read More about Proportionate methods for evaluating a simple digital mental health tool.

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., …Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, https://doi.org/10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More about Principles of early human development and germ cell program from conserved model systems.

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development (2017)
Journal Article
Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., …Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. https://doi.org/10.1016/j.placenta.2017.02.018

The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy,... Read More about Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development.

Healing Spaces, Modern Architecture, and the Body (2016)
Book
Schrank, S., & Ekici, D. (2018). D. Ekici, & S. Schrank (Eds.). Healing Spaces, Modern Architecture, and the Body. London: Routledge. https://doi.org/10.4324/9781315586298

Healing Spaces, Modern Architecture, and the Body brings together cutting-edge scholarship examining the myriad ways that architects, urban planners, medical practitioners, and everyday people have applied modern ideas about health and the body to th... Read More about Healing Spaces, Modern Architecture, and the Body.

The Physiology of the House: Modern Architecture and the Science of Hygiene (2016)
Book Chapter
Ekici, D. (2018). The Physiology of the House: Modern Architecture and the Science of Hygiene. In Healing Spaces, Modern Architecture, and the Body (47-64). London: Routledge

Regulation of vascular endothelial growth factor in prostate cancer (2015)
Journal Article
de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D. M., …Mongan, N. P. (2015). Regulation of vascular endothelial growth factor in prostate cancer. Endocrine-Related Cancer, 22(3), Article R107-R123. https://doi.org/10.1530/ERC-15-0123

Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ∼30% will experience local recurrence or metast... Read More about Regulation of vascular endothelial growth factor in prostate cancer.

Privacy Preserving Corpus Linguistics: Investigating the Trajectories of Public Health Messaging Online
Report
McClaughlin, E., Nichele, E., Adolphs, S., Barnard, P., Clos, J., Knight, D., …Lang, A. (2022). Privacy Preserving Corpus Linguistics: Investigating the Trajectories of Public Health Messaging Online. University of Nottingham: AHRC/UKRI

The Coronavirus Discourses project supports public health partners Public Health Wales, Public Health England, and NHS Education for Scotland in addressing key challenges that the coronavirus pandemic presents in terms of understanding the flow and i... Read More about Privacy Preserving Corpus Linguistics: Investigating the Trajectories of Public Health Messaging Online.