Dr ANTO RAJAMANI's Outputs (15)

Systematic review of pharmacological interventions for people with Lewy body dementia (2022)
Journal Article
Watts, K. E., Storr, N. J., Barr, P. G., & Rajkumar, A. P. (2022). Systematic review of pharmacological interventions for people with Lewy body dementia. Aging and Mental Health, 27(2), 203-216. https://doi.org/10.1080/13607863.2022.2032601

Objective: Lewy body dementia (LBD) is the second most common neurodegenerative dementia, and it causes earlier mortality and more morbidity than Alzheimer’s disease. Reviewing current evidence on its pharmacological management is essential for devel... Read More about Systematic review of pharmacological interventions for people with Lewy body dementia.

Next-generation RNA-Sequencing of serum small extracellular vesicles discovers potential diagnostic biomarkers for dementia with Lewy bodies (2020)
Journal Article
Rajkumar, A. P., Hye, A., Lange, J., Rashid Manesh, Y., Ballard, C., Fladby, T., & Aarsland, D. (2021). Next-generation RNA-Sequencing of serum small extracellular vesicles discovers potential diagnostic biomarkers for dementia with Lewy bodies. American Journal of Geriatric Psychiatry, 29(6), 573-584. https://doi.org/10.1016/j.jagp.2020.10.012

Objectives: There is an urgent clinical need for identifying blood-based diagnostic biomarkers for Dementia with Lewy Bodies (DLB). Transcriptomic studies have reported unique RNA changes in post-mortem DLB brains. Small extracellular vesicles (SEV)... Read More about Next-generation RNA-Sequencing of serum small extracellular vesicles discovers potential diagnostic biomarkers for dementia with Lewy bodies.

Perspectives of GCSE students attending a psychiatry summer school in south London (2020)
Journal Article
Wyke, C., de Bernier, G.-L., Lam, C. C. S. F., Holt, C., Butler, S., Rajamani, A. P. R., & Wilson Jones, C. (2021). Perspectives of GCSE students attending a psychiatry summer school in south London. BJPsych Bulletin, 45(2), 114-119. https://doi.org/10.1192/bjb.2020.76

AIMS AND METHOD

To evaluate a pilot psychiatry summer school for GCSE students in terms of participant experience, impact on attitudes to mental illness and perception of psychiatry as a career option. This was performed using the Community Attitu... Read More about Perspectives of GCSE students attending a psychiatry summer school in south London.

Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice (2020)
Journal Article
Rajkumar, A. P., Qvist, P., Donskov, J. G., Lazarus, R., Pallesen, J., Nava, N., …Børglum, A. D. (2020). Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice. Translational Psychiatry, 10(1), Article 239. https://doi.org/10.1038/s41398-020-00914-2

The schizophrenia-associated gene, BRD1, encodes an epigenetic regulator in which chromatin interactome is enriched with genes implicated in mental health. Alterations in histone modifications and epigenetic regulation contribute to brain transcripto... Read More about Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders (2020)
Journal Article
Ashton, N. J., Hye, A., Rajkumar, A. P., Leuzy, A., Snowden, S., Suárez-Calvet, M., …Aarsland, D. (2020). An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders. Nature Reviews Neurology, 16, 265-284. https://doi.org/10.1038/s41582-020-0348-0

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for... Read More about An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders.

Systematic review of gene expression studies in people with Lewy body dementia (2020)
Journal Article
Chowdhury, A., & Rajkumar, A. P. (2020). Systematic review of gene expression studies in people with Lewy body dementia. Acta Neuropsychiatrica, 32(6), 281-292. https://doi.org/10.1017/neu.2020.13

Objectives:
Lewy body dementia (LBD) is the second most prevalent neurodegenerative dementia, and it causes more morbidity and mortality than Alzheimer's disease. Several genetic associations of LBD have been reported, and their functional implicati... Read More about Systematic review of gene expression studies in people with Lewy body dementia.

Systematic review of genetic association studies in people with Lewy body dementia (2020)
Journal Article
Sanghvi, H., Singh, R., Morrin, H., & Rajkumar, A. P. (2020). Systematic review of genetic association studies in people with Lewy body dementia. International Journal of Geriatric Psychiatry, 35(5), 436-448. https://doi.org/10.1002/gps.5260

Objectives

Lewy body dementia (LBD) causes more morbidity, disability, and earlier mortality than Alzheimer disease. Molecular mechanisms underlying neurodegeneration in LBD are poorly understood. We aimed to do a systematic review of all genetic... Read More about Systematic review of genetic association studies in people with Lewy body dementia.

Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview (2020)
Journal Article
De Leon, J., Rajkumar, A. P., Kaithi, A. R., Schoretsanitis, G., Kane, J. M., Wang, C. Y., …Andrade, C. (2020). Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview. Indian Journal of Psychological Medicine, 42(1), 4-10. https://doi.org/10.4103/IJPSYM.IJPSYM_379_19

© 2020 Indian Psychiatric Society - South Zonal Branch | Published by Wolters Kluwer - Medknow. Since 1997, studies have found that Asians need lower clozapine doses than Caucasians. Caucasians with average clozapine metabolism may need from 300 to 6... Read More about Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview.

Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13% (2019)
Journal Article
Ruan, C.-J., Wang, C.-Y., Tang, Y.-L., Lin, S.-K., Lee, S.-T., Hong, K. S., …De Leon, J. (2019). Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13%. Journal of Clinical Psychopharmacology, 39(6), 644-648. https://doi.org/10.1097/JCP.0000000000001125

Purpose/Background: Clozapine clearance is influenced by sex, smoking status, ethnicity, co-prescription of inducers or inhibitors, obesity and inflammation. In 126 Beijing inpatients, we measured repeated trough steady-state serum concentrations and... Read More about Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13%.

Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease (2019)
Journal Article
D’Souza, T., & Rajkumar, A. P. (2019). Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease. Acta Neuropsychiatrica, 1-13. https://doi.org/10.1017/neu.2019.28

Objective:
Cognitive impairment and depression are among the most prevalent and most disabling non-motor symptoms in Parkinson’s disease (PD). The genetic factors that are associated with these symptoms remain uncertain. This systematic review aims... Read More about Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease.

Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation (2019)
Journal Article
Rajkumar, A. P., Bidkhori, G., Shoaie, S., Clarke, E., Morrin, H., Hye, A., …Aarsland, D. (2020). Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation. American Journal of Geriatric Psychiatry, 28(1), 75-86. https://doi.org/10.1016/j.jagp.2019.06.007

Objectives: Prevalence of Lewy body dementias (LBD) is second only to Alzheimer's disease (AD) among people with neurodegenerative dementia. LBD cause earlier mortality, more intense neuropsychiatric symptoms, more caregivers' burden, and higher cost... Read More about Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation.

Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study (2017)
Journal Article
Rajkumar, A. P., Horsdal, H. T., Wimberley, T., Cohen, D., Mors, O., Børglum, A. D., & Gasse, C. (2017). Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study. American Journal of Psychiatry, 174(7), 686-694. https://doi.org/10.1176/appi.ajp.2016.16040442

Objective: Diabetes mellitus contributes to excessive cardiovascular deaths and reduced life expectancy in schizophrenia. This population-based cohort study investigated the endogenous risk for diabetes in antipsychotic-naive schizophrenia and evalua... Read More about Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study.

The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice (2016)
Journal Article
Børglum, A. D., Qvist, P., Didriksen, M., Christensen, J. H., Mors, O., Vardya, I., …Dyrvig, M. (2017). The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice. Biological Psychiatry, 82(1), 62-76. https://doi.org/10.1016/j.biopsych.2016.08.037

Health, Social, and Economic Variables Associated with Depression Among Older People in Low and Middle Income Countries: World Health Organization Study on Global AGEing and Adult Health (2016)
Journal Article
Brinda, E. M., Rajkumar, A. P., Attermann, J., Gerdtham, U. G., Enemark, U., & Jacob, K. S. (2016). Health, Social, and Economic Variables Associated with Depression Among Older People in Low and Middle Income Countries: World Health Organization Study on Global AGEing and Adult Health. American Journal of Geriatric Psychiatry, 24(12), 1196-1208. https://doi.org/10.1016/j.jagp.2016.07.016

Objective
Although depression among older people is an important public health problem worldwide, systematic studies evaluating its prevalence and determinants in low and middle income countries (LMICs) are sparse. The biopsychosocial model of dep... Read More about Health, Social, and Economic Variables Associated with Depression Among Older People in Low and Middle Income Countries: World Health Organization Study on Global AGEing and Adult Health.

Apathy and Its Response to Antipsychotic Review and Nonpharmacological Interventions in People With Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial (2016)
Journal Article
Rajkumar, A. P., Ballard, C., Fossey, J., Corbett, A., Woods, B., Orrell, M., …Testad, I. (2016). Apathy and Its Response to Antipsychotic Review and Nonpharmacological Interventions in People With Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial. Journal of the American Medical Directors Association, 17(8), 741-747. https://doi.org/10.1016/j.jamda.2016.04.006

Objectives
Apathy is common, impactful, and difficult to manage in people with dementia. We evaluated the efficacy of nonpharmacological interventions, exercise, and social interaction, in combination with antipsychotic review, to reduce apathy in p... Read More about Apathy and Its Response to Antipsychotic Review and Nonpharmacological Interventions in People With Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial.