Jose De Leon
Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview
De Leon, Jose; Rajkumar, Anto P.; Kaithi, Arun R.; Schoretsanitis, Georgios; Kane, John M.; Wang, Chuan Yue; Tang, Yi Lang; Lin, Shih Ku; Sue Hong, Kyung; Farooq, Saeed; Ng, Chee H.; Ruan, Can Jun; Andrade, Chittaranjan
Authors
Dr ANTO RAJAMANI Anto.Rajamani@nottingham.ac.uk
Clinical Associate Professor
Arun R. Kaithi
Georgios Schoretsanitis
John M. Kane
Chuan Yue Wang
Yi Lang Tang
Shih Ku Lin
Kyung Sue Hong
Saeed Farooq
Chee H. Ng
Can Jun Ruan
Chittaranjan Andrade
Abstract
© 2020 Indian Psychiatric Society - South Zonal Branch | Published by Wolters Kluwer - Medknow. Since 1997, studies have found that Asians need lower clozapine doses than Caucasians. Caucasians with average clozapine metabolism may need from 300 to 600 mg/day to reach the therapeutic range (350 ng/ml). Thus, serum clozapine concentration-to-dose (C/D) ratios typically range between 0.60 (male smokers) and 1.20 (female non-smokers). A 2019 systematic review of clozapine levels demonstrated weighted mean C/D ratios of 1.57 in 876 East Asians and 1.07 in 1147 Caucasians (P
Citation
De Leon, J., Rajkumar, A. P., Kaithi, A. R., Schoretsanitis, G., Kane, J. M., Wang, C. Y., …Andrade, C. (2020). Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview. Indian Journal of Psychological Medicine, 42(1), 4-10. https://doi.org/10.4103/IJPSYM.IJPSYM_379_19
Journal Article Type | Review |
---|---|
Acceptance Date | Oct 7, 2019 |
Online Publication Date | Jan 6, 2020 |
Publication Date | Jan 1, 2020 |
Deposit Date | Oct 15, 2019 |
Publicly Available Date | Oct 15, 2019 |
Journal | Indian Journal of Psychological Medicine |
Print ISSN | 0253-7176 |
Electronic ISSN | 0975-1564 |
Publisher | Medknow Publications |
Peer Reviewed | Peer Reviewed |
Volume | 42 |
Issue | 1 |
Pages | 4-10 |
DOI | https://doi.org/10.4103/IJPSYM.IJPSYM_379_19 |
Keywords | Clinical Psychology |
Public URL | https://nottingham-repository.worktribe.com/output/2836900 |
Publisher URL | http://www.ijpm.info/article.asp?issn=0253-7176;year=2020;volume=42;issue=1;spage=4;epage=10;aulast=de |
Contract Date | Oct 15, 2019 |
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