Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview

De Leon, Jose; Rajkumar, Anto P.; Kaithi, Arun R.; Schoretsanitis, Georgios; Kane, John M.; Wang, Chuan Yue; Tang, Yi Lang; Lin, Shih Ku; Sue Hong, Kyung; Farooq, Saeed; Ng, Chee H.; Ruan, Can Jun; Andrade, Chittaranjan

Abstract

© 2020 Indian Psychiatric Society - South Zonal Branch | Published by Wolters Kluwer - Medknow. Since 1997, studies have found that Asians need lower clozapine doses than Caucasians. Caucasians with average clozapine metabolism may need from 300 to 600 mg/day to reach the therapeutic range (350 ng/ml). Thus, serum clozapine concentration-to-dose (C/D) ratios typically range between 0.60 (male smokers) and 1.20 (female non-smokers). A 2019 systematic review of clozapine levels demonstrated weighted mean C/D ratios of 1.57 in 876 East Asians and 1.07 in 1147 Caucasians (P

Citation

De Leon, J., Rajkumar, A. P., Kaithi, A. R., Schoretsanitis, G., Kane, J. M., Wang, C. Y., Tang, Y. L., Lin, S. K., Sue Hong, K., Farooq, S., Ng, C. H., Ruan, C. J., & Andrade, C. (2020). Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview. Indian Journal of Psychological Medicine, 42(1), 4-10. https://doi.org/10.4103/IJPSYM.IJPSYM_379_19

• Journal Article Type: Review
• Acceptance Date: Oct 7, 2019
• Online Publication Date: Jan 6, 2020
• Publication Date: Jan 1, 2020
• Deposit Date: Oct 15, 2019
• Publicly Available Date: Oct 15, 2019
• Journal: Indian Journal of Psychological Medicine
• Print ISSN: 0253-7176
• Electronic ISSN: 0975-1564
• Publisher: Medknow Publications
• Peer Reviewed: Peer Reviewed
• Volume: 42
• Issue: 1
• Pages: 4-10
• DOI: https://doi.org/10.4103/IJPSYM.IJPSYM_379_19
• Keywords: Clinical Psychology
• Public URL: https://nottingham-repository.worktribe.com/output/2836900
• Publisher URL: http://www.ijpm.info/article.asp?issn=0253-7176;year=2020;volume=42;issue=1;spage=4;epage=10;aulast=de
• Contract Date: Oct 15, 2019