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Dr Mischa Zelzer's Outputs (17)

PLGA-PEG-PLGA hydrogels induce cytotoxicity in conventional in vitro assays (2024)
Journal Article
Stewart, C. L., Hook, A. L., Zelzer, M., Marlow, M., & Piccinini, A. M. (2024). PLGA-PEG-PLGA hydrogels induce cytotoxicity in conventional in vitro assays. Cell Biochemistry and Function, 42(5), Article e4097. https://doi.org/10.1002/cbf.4097

We identified that PLGA-PEG-PLGA hydrogels, which have been used in human clinical trials and possess a demonstrable safety profile, induced significant cytotoxicity in conventional in vitro assays. This major contradiction may lead to inconsistent a... Read More about PLGA-PEG-PLGA hydrogels induce cytotoxicity in conventional in vitro assays.

Cellular and microenvironmental cues that promote macrophage fusion and foreign body response (2024)
Journal Article
Stewart, C. L., Marlow, M., Zelzer, M., Hook, A. L., & Piccinini, A. M. (in press). Cellular and microenvironmental cues that promote macrophage fusion and foreign body response. Frontiers in Immunology, 15, https://doi.org/10.3389/fimmu.2024.1411872

During the foreign body response (FBR), macrophages fuse to form foreign body giant cells (FBGCs). Modulation of FBGC formation can prevent biomaterial degradation and loss of therapeutic efficacy. However, the microenvironmental cues that dictate FB... Read More about Cellular and microenvironmental cues that promote macrophage fusion and foreign body response.

A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus (2022)
Journal Article
Catania, R., Onion, D., Russo, E., Zelzer, M., Mantovani, G., Huett, A., & Stolnik, S. (2022). A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus. RSC Advances, 12(26), 16561-16569. https://doi.org/10.1039/d2ra02307e

Control over intracellular release of therapeutic compounds incorporated into nano-carriers will open new possibilities for targeted treatments of various diseases including cancer, and viral and bacterial infections. Here we report our study on mech... Read More about A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus.

Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration (2022)
Journal Article
Teja Surikutchi, B., Obenza-Otero, R., Russo, E., Zelzer, M., Golán Cancela, I., Costoya, J. A., Crecente Campo, J., José Alonso, M., & Marlow, M. (2022). Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration. International Journal of Pharmaceutics, 622, Article 121828. https://doi.org/10.1016/j.ijpharm.2022.121828

Intraperitoneal (IP) drug delivery of chemotherapeutic agents, administered through hyperthermal intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosolized chemotherapy (PIPAC), is effective for the treatment of peritoneal malig... Read More about Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration.

Quantifiable correlation of ToF-SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content (2022)
Journal Article
Taylor, M., Simoes, F., Smith, J., Genapathy, S., Canning, A., Lledos, M., Chan, W. C., Denning, C., Scurr, D. J., Steven, R. T., Spencer, S. J., Shard, A. G., Alexander, M. R., & Zelzer, M. (2022). Quantifiable correlation of ToF-SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content. Surface and Interface Analysis, 54(4), 417-432. https://doi.org/10.1002/sia.7052

Peptide-coated surfaces are widely employed in biomaterial design, but quantifiable correlation between surface composition and biological response is challenging due to, for example, instrumental limitations, a lack of suitable model surfaces or lim... Read More about Quantifiable correlation of ToF-SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content.

Surface-controlled spatially heterogeneous physical properties of a supramolecular gel with homogeneous chemical composition (2021)
Journal Article
Yang, B., Lledos, M., Akhtar, R., Ciccone, G., Jiang, L., Russo, E., Rajput, S., Jin, C., Angelereou, M. G. F., Arnold, T., Rawle, J., Vassalli, M., Marlow, M., Adams, D. J., & Zelzer, M. (2021). Surface-controlled spatially heterogeneous physical properties of a supramolecular gel with homogeneous chemical composition. Chemical Science, 12(42), 14260-14269. https://doi.org/10.1039/d1sc04671c

Controlling supramolecular self-assembly across multiple length scales to prepare gels with localised properties is challenging. Most strategies concentrate on fabricating gels with heterogeneous components, where localised properties are generated b... Read More about Surface-controlled spatially heterogeneous physical properties of a supramolecular gel with homogeneous chemical composition.

Hydrophobicity of surface-immobilised molecules influences architectures formed via interfacial self-assembly of nucleoside-based gelators (2018)
Journal Article
Angelerou, M. G. F., Yang, B., Arnold, T., Rawle, J., Marlow, M., & Zelzer, M. (2018). Hydrophobicity of surface-immobilised molecules influences architectures formed via interfacial self-assembly of nucleoside-based gelators. Soft Matter, 14(48), 9851-9855. https://doi.org/10.1039/c8sm01868e

Surface-mediated self-assembly has potential in biomaterial development but underlying rules governing surface-gelator interactions are poorly understood. Here, we correlate surface properties with structural characterization data of nucleoside-based... Read More about Hydrophobicity of surface-immobilised molecules influences architectures formed via interfacial self-assembly of nucleoside-based gelators.

Surface-Mediated Supramolecular Self-Assembly of Protein, Peptide, and Nucleoside Derivatives: From Surface Design to the Underlying Mechanism and Tailored Functions (2018)
Journal Article
Yang, B., Adams, D. J., Marlow, M., & Zelzer, M. (2018). Surface-Mediated Supramolecular Self-Assembly of Protein, Peptide, and Nucleoside Derivatives: From Surface Design to the Underlying Mechanism and Tailored Functions. Langmuir, 34(50), 15109-15125. https://doi.org/10.1021/acs.langmuir.8b01165

Among the many parameters that have been explored to exercise control over self-assembly processes, the influence of surface properties on self-assembly has been recognized as important but has received considerably less attention than other factors.... Read More about Surface-Mediated Supramolecular Self-Assembly of Protein, Peptide, and Nucleoside Derivatives: From Surface Design to the Underlying Mechanism and Tailored Functions.

Supramolecular nucleoside-based gel: molecular dynamics simulation and characterization of its nanoarchitecture and self-assembly mechanism (2018)
Journal Article
Angelerou, M. G., Frederix, P. W., Wallace, M., Yang, B., Rodger, A., Adams, D. J., Marlow, M., & Zelzer, M. (2018). Supramolecular nucleoside-based gel: molecular dynamics simulation and characterization of its nanoarchitecture and self-assembly mechanism. Langmuir, 34(23), https://doi.org/10.1021/acs.langmuir.8b00646

Among the diversity of existing supramolecular hydrogels, nucleic acid-based hydrogels are of particular interest for potential drug delivery and tissue engineering applications because of their inherent biocompatibility. Hydrogel performance is dire... Read More about Supramolecular nucleoside-based gel: molecular dynamics simulation and characterization of its nanoarchitecture and self-assembly mechanism.

Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation (2016)
Journal Article
Roberts, J., Sahoo, J., McNamara, L., Burgess, K., Yang, J., Alakpa, E., Anderson, H., Hay, J., Turner, L.-A., Yarwood, S., Zelzer, M., Oreffo, R., Ulijn, R., & Dalby, M. (2016). Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation. ACS Nano, 10(7), 6667-6679. https://doi.org/10.1021/acsnano.6b01765

Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use challenging. Tr... Read More about Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation.

Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks (2015)
Journal Article
Van Nuffel, S., Parmenter, C. D., Scurr, D. J., Russell, N. A., & Zelzer, M. (in press). Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks. Analyst, 141(1), https://doi.org/10.1039/c5an01743b

Advanced data analysis tools are crucial for the application of ToF-SIMS analysis to biological samples. Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of ne... Read More about Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks.

3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling (2015)
Journal Article
Taylor, M., Scurr, D., Lutolf, M., Buttery, L. D., Zelzer, M., & Alexander, M. R. (2015). 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling. Biointerphases, 11(2), Article 02A301. https://doi.org/10.1116/1.4928209

Hydrogels have been used extensively in bioengineering as artificial cell culture supports. Investigation of the interrelationship between cellular response to the hydrogel and its chemistry ideally requires methods that allow characterization withou... Read More about 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling.

Responsive cell–material interfaces (2015)
Journal Article
Dhowre, H. S., Rajput, S., Russell, N. A., & Zelzer, M. (2015). Responsive cell–material interfaces. Nanomedicine, 10(5), https://doi.org/10.2217/nnm.14.225

Major design aspects for novel biomaterials are driven by the desire to mimic more varied and complex properties of a natural cellular environment with man-made materials. The development of stimulus responsive materials makes considerable contributi... Read More about Responsive cell–material interfaces.

Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides (2014)
Journal Article
Krishna Mohan Nalluri, S., Shivarova, N., Kanibolotsky, A. L., Zelzer, M., Gupta, S., Frederix, P. W., Skabara, P. J., Gleskova, H., & Ulijn, R. V. (2014). Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides. Langmuir, 30(41), 12429-12437. https://doi.org/10.1021/la503459y

We demonstrate the nonaqueous self-assembly of a low-molecular-mass organic gelator based on an electroactive p-type tetrathiafulvalene (TTF)–dipeptide bioconjugate. We show that a TTF moiety appended with diphenylalanine amide derivative (TTF-FF-NH2... Read More about Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides.

Interface and surface analysis for pharmaceutical applications: challenges and recent advances (2014)
Journal Article
Piggott, M. J., & Zelzer, M. (2014). Interface and surface analysis for pharmaceutical applications: challenges and recent advances. Chimica Oggi, 32(5),

Innovation in R&D is a key target for the pharmaceutical sector to address some of the challenges it currently faces. This review discusses these challenges in the context of pharmaceutically relevant surfaces and interfaces. The surface properties o... Read More about Interface and surface analysis for pharmaceutical applications: challenges and recent advances.