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Outputs (57)

Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development (2023)
Journal Article
Cornwall, N., Knaggs, R., Woodcock, C., Ashworth, J., Harrisson, S. A., Dikomitis, L., …on behalf of the PROMPPT team. (2023). Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development. British Journal of Pain, https://doi.org/10.1177/20494637231221688

Introduction Regular review of patients prescribed opioids for persistent non-cancer pain (PCNP) is recommended but not routinely undertaken. The PROMPPT (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led... Read More about Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development.

Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records (2023)
Journal Article
Joseph, R. M., Knaggs, R. D., Coupland, C. A., Taylor, A., Vinogradova, Y., Butler, D., …Jack, R. H. (2023). Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records. BMC Geriatrics, 23(1), Article 435. https://doi.org/10.1186/s12877-023-04143-2

Background Medication reviews in primary care provide an opportunity to review and discuss the safety and appropriateness of a person’s medicines. However, there is limited evidence about access to and the impact of routine medication reviews for old... Read More about Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records.

Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data (2023)
Journal Article
Coates, G., Clewes, P., Lohan, C., Stevenson, H., Wood, R., Tritton, T., …Walsh, D. (2023). Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data. BMJ Open, 13(7), Article e067545. https://doi.org/10.1136/bmjopen-2022-067545

Objective: Despite the prevalence of osteoarthritis (OA) in England, few studies have examined the health economic impact of chronic pain associated with OA. The aim of this study was to compare outcomes in patients with moderate-to-severe chronic pa... Read More about Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data.

Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis (2023)
Journal Article
Liu, S., Athar, A., Quach, D., Patanwala, A. E., Naylor, J. M., Stevens, J. A., …Penm, J. (2023). Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis. Anaesthesia, 78(10), 1225-1236. https://doi.org/10.1111/anae.16085

Prescription of modified-release opioids for acute postoperative pain is widespread despite evidence to show their use may be associated with an increased risk of adverse effects. This systematic review and meta-analysis aimed to examine the availabl... Read More about Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis.

Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study (2023)
Journal Article
Liu, S., Patanwala, A. E., Naylor, J. M., Levy, N., Knaggs, R., Stevens, J. A., …Penm, J. (2023). Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study. Anaesthesia, 78(10), 1237-1248. https://doi.org/10.1111/anae.16070

Modified-release opioids are often prescribed for the management of moderate to severe acute pain following total hip and knee arthroplasty, despite recommendations against their use due to increasing concerns regarding harm. The primary objective of... Read More about Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study.

Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., & Lobo, D. N. (2023). Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England. Anaesthesia, 78(9), 1081-1092. https://doi.org/10.1111/anae.16055

This retrospective cohort study on adults undergoing colectomy from 2010 to 2019 used linked primary (Clinical Practice Research Datalink), and secondary (Hospital Episode Statistics) care data to determine the prevalence of persistent postoperative... Read More about Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. (0000). The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study. British Journal of Surgery, 110(Supplement 3), Article znad101.128. https://doi.org/10.1093/bjs/znad101.128

Introduction Opioid prescribing patterns after discharge following colectomy within a population from England are not well characterised. This study aimed to report changes in opioid prescribing prevalence, formulation choices and opioid analgesics o... Read More about O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study.

O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England. British Journal of Surgery, 110(Supplement 3), Article znad101.087. https://doi.org/10.1093/bjs/znad101.087

Introduction Little is known regarding whether opioid prescriptions following colectomy lead to persistent use. We aimed to determine the prevalence of persistent post-discharge opioid use following colectomy, stratified by preadmission opioid exposu... Read More about O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England.

Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data (2023)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2023). Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data. Pain Practice, https://doi.org/10.1111/papr.13212

Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti-epileptic d... Read More about Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data.

Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study (2022)
Journal Article
Anderson, C., Iqbal, A., Knaggs, R., & Toh, L. S. (2023). Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study. International Journal of Clinical Pharmacy, 45, 220-232. https://doi.org/10.1007/s11096-022-01493-6

Background Opioids are commonly used for the management of chronic non-malignant pain in Pakistan; but there is a lack of literature around precursors or motivators in the use of opioids. Aim The study holistically explored factors contributing towa... Read More about Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study.

Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong (2022)
Journal Article
Crush, J., Levy, N., Knaggs, R. D., & Lobo, D. N. (2022). Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong. British Journal of Anaesthesia, 129(2), 137-142. https://doi.org/10.1016/j.bja.2022.03.004

Opioids have a vital role in alleviating pain from cancer and surgery. Despite good intentions, it is now recognised that the original WHO Cancer Pain Relief guidance from 1986, in which opioids were classified as either weak or strong, has been both... Read More about Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong.

System-level policies on appropriate opioid use, a multi-stakeholder consensus (2022)
Journal Article
Forget, P., Patullo, C., Hill, D., Ambekar, A., Baldacchino, A., Cata, J., …Gilbert, S. (2022). System-level policies on appropriate opioid use, a multi-stakeholder consensus. BMC Health Services Research, 22(1), Article 329. https://doi.org/10.1186/s12913-022-07696-x

Background: This consensus statement was developed because there are concerns about the appropriate use of opioids for acute pain management, with opposing views in the literature. Consensus statement on policies for system-level interventions may he... Read More about System-level policies on appropriate opioid use, a multi-stakeholder consensus.

Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records. Evidence-Based Mental Health, 25(4), 169-176. https://doi.org/10.1136/ebmental-2021-300355

BACKGROUND: Studies report an increased risk of self-harm or suicide in people prescribed mirtazapine compared with other antidepressants. OBJECTIVES: To compare the risk of serious self-harm in people prescribed mirtazapine versus other antidepressa... Read More about Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records. BMC Medicine, 20(1), Article 43. https://doi.org/10.1186/s12916-022-02247-x

Background Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults prescribed mirtazapine or other s... Read More about The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records.

Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review (2022)
Journal Article
Baamer, R. M., Iqbal, A., Lobo, D. N., Knaggs, R. D., Levy, N. A., & Toh, L. S. (2022). Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review. British Journal of Anaesthesia, 128(5), 874-888. https://doi.org/10.1016/j.bja.2021.11.032

Background: We aimed to appraise the evidence relating to the measurement properties of unidimensional tools to quantify pain after surgery. Furthermore, we wished to identify the tools used to assess interference of pain with functional recovery. Me... Read More about Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review.

Association between opioid-related deaths and prescribed opioid dose and psychotropic medicines in England: a case-crossover study (2021)
Journal Article
Chen, T., Knaggs, R. D., & Chen, L. (2021). Association between opioid-related deaths and prescribed opioid dose and psychotropic medicines in England: a case-crossover study. British Journal of Anaesthesia, 127(5), 789-797. https://doi.org/10.1016/j.bja.2021.06.049

Background Opioid-overdose deaths are associated with poisoning with prescription and illicit opioids in the USA. In contrast, opioid-related deaths (ORDs) in the UK often involve drugs and substances of misuse, and may not be associated with a hi... Read More about Association between opioid-related deaths and prescribed opioid dose and psychotropic medicines in England: a case-crossover study.

Association between opioid‐related deaths and persistent opioid prescribing in primary care in England: a nested case‐control study (2021)
Journal Article
Chen, T., Knaggs, R. D., & Chen, L. (2022). Association between opioid‐related deaths and persistent opioid prescribing in primary care in England: a nested case‐control study. British Journal of Clinical Pharmacology, 88(2), 798-809. https://doi.org/10.1111/bcp.15028

Aim This study aimed to evaluate the association between opioid-related deaths and persistent opioid utilisation in the United Kingdom (UK). Methods This nested case-control study used the UK Clinical Practice Research Datalink, linking the Offi... Read More about Association between opioid‐related deaths and persistent opioid prescribing in primary care in England: a nested case‐control study.

Characterising the outcomes, impacts and implementation challenges of advanced clinical practice roles in the UK: A scoping review (2021)
Journal Article
Evans, C., Poku, B. A., Pearce, R., Eldridge, J., Hendrick, P., Knaggs, R., …Collier, R. (2021). Characterising the outcomes, impacts and implementation challenges of advanced clinical practice roles in the UK: A scoping review. BMJ Open, 11(8), Article e048171. https://doi.org/10.1136/bmjopen-2020-048171

Objectives In response to demographic and health system pressures, the development of non-medical advanced clinical practice (ACP) roles is a key component of National Health Service workforce transformation policy in the UK. This review was undertak... Read More about Characterising the outcomes, impacts and implementation challenges of advanced clinical practice roles in the UK: A scoping review.

Collaboration between adult patients and practitioners when making decisions about prescribing opioid medicines for chronic non-cancer pain in primary care: a scoping review (2021)
Journal Article
Bathia, N. S., McAskill, R. E., Hancox, J. E., & Knaggs, R. D. (2022). Collaboration between adult patients and practitioners when making decisions about prescribing opioid medicines for chronic non-cancer pain in primary care: a scoping review. British Journal of Pain, 16(1), 119-126. https://doi.org/10.1177/20494637211025560

Background: Long-term opioid therapy (>12 months) is not effective for improving chronic non-cancer pain and function. Where patients are not experiencing pain relief with long-term opioids, the opioid should be tapered and discontinuation considered... Read More about Collaboration between adult patients and practitioners when making decisions about prescribing opioid medicines for chronic non-cancer pain in primary care: a scoping review.

Is Europe also facing an opioid crisis? ? A survey of European Pain Federation chapters (2021)
Journal Article
Häuser, W., Buchser, E., Finn, D., Dom, G., Fors, E., Heiskanen, T., …Morlion, B. (2021). Is Europe also facing an opioid crisis? ‐ A survey of European Pain Federation chapters. European Journal of Pain, 25(8), 1760-1769. https://doi.org/10.1002/ejp.1786

Background There is considerable public interest in whether Europe is facing an opioid crisis comparable to the one in the United States and the contribution of opioid prescriptions for pain to a potential opioid crisis. Methods A task force... Read More about Is Europe also facing an opioid crisis? ? A survey of European Pain Federation chapters.

Characterization and Associated Costs of Constipation Relating to Exposure to Strong Opioids in England: An Observational Study (2021)
Journal Article
Morgan, C. L., Jenkins-Jones, S., Knaggs, R., Currie, C., Conway, P., Poole, C. D., & Berni, E. (2021). Characterization and Associated Costs of Constipation Relating to Exposure to Strong Opioids in England: An Observational Study. Clinical Therapeutics, https://doi.org/10.1016/j.clinthera.2021.03.021

Purpose Opioid use is associated with gastrointestinal adverse events, including nausea and constipation. We used a real-world dataset to characterize the health care burden associated with opioid-induced constipation (OIC) with particular emphasis... Read More about Characterization and Associated Costs of Constipation Relating to Exposure to Strong Opioids in England: An Observational Study.

Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records (2021)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2021). Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records. Osteoarthritis and Cartilage, 3(2), Article 100165. https://doi.org/10.1016/j.ocarto.2021.100165

Objective To examine the association between the current use of analgesics and the risk of falls in people with knee osteoarthritis (KOA). Methods A retrospective cohort study using data from the UK Clinical Practice Research Datalink, with... Read More about Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records.

Surgery and opioids: evidence-based expert consensus guidelines on the perioperative use of opioids in the United Kingdom (2021)
Journal Article
Srivastava, D., Hill, S., Carty, S., Rockett, M., Bastable, R., Knaggs, R., …Wilkinson, P. (2021). Surgery and opioids: evidence-based expert consensus guidelines on the perioperative use of opioids in the United Kingdom. British Journal of Anaesthesia, 126(6), 1208-1216. https://doi.org/10.1016/j.bja.2021.02.030

There are significant concerns regarding prescription and misuse of prescription opioids in the perioperative period. The Faculty of Pain Medicine at the Royal College of Anaesthetists have produced this evidence-based expert consensus guideline on s... Read More about Surgery and opioids: evidence-based expert consensus guidelines on the perioperative use of opioids in the United Kingdom.

Opioid prescription at postoperative discharge: a retrospective observational cohort study (2021)
Journal Article
Daliya, P., Adiamah, A., Roslan, F., Theophilidou, E., Knaggs, R., Levy, N., & Lobo, D. (2021). Opioid prescription at postoperative discharge: a retrospective observational cohort study. Anaesthesia, 76(10), 1367-1376. https://doi.org/10.1111/anae.15460

Opioid misuse is now considered a major public health epidemic in North America, with substantial social and financial consequences. As well as socio-economic and commercial drivers, modifiable risk-factors that have resulted in this crisis have been... Read More about Opioid prescription at postoperative discharge: a retrospective observational cohort study.

Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink (2021)
Journal Article
Peach, E., Pearce, F., Gibson, J., Cooper, A., Chen, L., & Knaggs, R. (2021). Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink. American Journal of Epidemiology, 190(7), 1324-1331. https://doi.org/10.1093/aje/kwab042

Self-controlled study designs can be used to assess the association between exposures and acute outcomes while controlling for important confounders. Using routinely collected health data, a self-controlled case series design was used to investigate... Read More about Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

Evidence-based clinical practice guidelines on the management of pain in older people – a summary report (2020)
Journal Article
Dunham, M., Schofield, P., & Knaggs, R. (2022). Evidence-based clinical practice guidelines on the management of pain in older people – a summary report. British Journal of Pain, 16(1), 6-13. https://doi.org/10.1177/2049463720976155

Objective: The objective of this study is to develop an update of the evidence-based guidelines for the management of pain in older people. Design: Review of evidence since 2010 using a systematic and consensus approach is performed. Results: Recogni... Read More about Evidence-based clinical practice guidelines on the management of pain in older people – a summary report.

Role of pharmacists in optimising opioid therapy for chronic non-malignant pain; A systematic review (2020)
Journal Article
Iqbal, A., Knaggs, R. D., Anderson, C., & Toh, L. S. (2022). Role of pharmacists in optimising opioid therapy for chronic non-malignant pain; A systematic review. Research in Social and Administrative Pharmacy, 18(3), 2352-2366. https://doi.org/10.1016/j.sapharm.2020.11.014

Background: Opioid optimisation is a global issue in Chronic Non-malignant Pain (CNMP) management. Objective: This systematic review aims to assess the effectiveness of interventions delivered by pharmacists in outpatient clinical settings, community... Read More about Role of pharmacists in optimising opioid therapy for chronic non-malignant pain; A systematic review.

The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety (2020)
Journal Article
Foo, I., Macfarlane, A. J. R., Srivastava, D., Bhaskar, A., Barker, H., Knaggs, R., …Smith, A. F. (2021). The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety. Anaesthesia, 76(2), 238-250. https://doi.org/10.1111/anae.15270

Intravenous lidocaine is used widely for its effect on postoperative pain and recovery but it can be, and has been, fatal when used inappropriately and incorrectly. The risk‐benefit ratio of i.v. lidocaine varies with type of surgery and with patient... Read More about The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety.

Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use? (2020)
Journal Article
Mody, S., Kirkdale, C. L., Thornley, T., Dickinson, A., Avery, A. J., Knaggs, R., …Bastable, R. (2020). Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use?. Pharmacy, 8(4), Article 185. https://doi.org/10.3390/pharmacy8040185

The misuse of opioids, including codeine which is sold over-the-counter (OTC) in United Kingdom (UK) community pharmacies, is a growing public health concern. An educational Patient Safety Card was developed and piloted to see if it nudged customers... Read More about Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use?.

An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients (2020)
Journal Article
Levy, N., Quinlan, J., El‐Boghdadly, K., Fawcett, W. J., Agarwal, V., Bastable, R. B., …Macintyre, P. E. (2020). An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients. Anaesthesia, 76(4), 520-536. https://doi.org/10.1111/anae.15262

This international multidisciplinary consensus statement was developed to provide balanced guidance on the safe peri‐operative use of opioids in adults. An international panel of healthcare professionals evaluated the literature relating to postopera... Read More about An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients.

Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study (2020)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Butler, D., …Hippisley-Cox, J. (2020). Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study. PLoS Medicine, 17(7), Article e1003215. https://doi.org/10.1371/journal.pmed.1003215

BACKGROUND: The use of antidepressants in children and adolescents remains controversial. We examined trends over time and variation in antidepressant prescribing in children and young people in England and whether the drugs prescribed reflected UK l... Read More about Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.

Particulate steroids in axial spinal blockade and the increasing role of patient consent: Les grains de sable dans l’engrenage (2020)
Journal Article
Munglani, R., Knaggs, R., & Eyre, G. (2020). Particulate steroids in axial spinal blockade and the increasing role of patient consent: Les grains de sable dans l’engrenage. British Journal of Pain, 14(2), 141-146. https://doi.org/10.1177/2049463720921199

The complexity of modern medical practice is such that it is very unlikely that on any single issue we can give a definitive answer in any circumstance, and in our view the medical debate as to the use of particulate corticosteroid medicines in axial... Read More about Particulate steroids in axial spinal blockade and the increasing role of patient consent: Les grains de sable dans l’engrenage.

Characterising the evidence base for advanced clinical practice in the UK: A scoping review protocol (2020)
Journal Article
Evans, C., Poku, B., Pearce, R., Eldridge, J., Hendrick, P., Knaggs, R., …Collier, R. (2020). Characterising the evidence base for advanced clinical practice in the UK: A scoping review protocol. BMJ Open, 10(5), Article e036192. https://doi.org/10.1136/bmjopen-2019-036192

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction A global health workforce crisis, coupled with ageing populations, wars and the rise of non-com... Read More about Characterising the evidence base for advanced clinical practice in the UK: A scoping review protocol.

Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database (2020)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C., Butler, D., Hollis, C., Morriss, R., …Hippisley-Cox, J. (2020). Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database. BMC Medicine, 18(1), https://doi.org/10.1186/s12916-020-01560-7

© 2020 The Author(s). Background: Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in children an... Read More about Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database.

Impact of smoking status on the efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review (2020)
Journal Article
Sonnex, K., Alleemudder, H., & Knaggs, R. (2020). Impact of smoking status on the efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review. BMJ Open, 10(4), https://doi.org/10.1136/bmjopen-2020-037509

Objectives: Inhaled corticosteroids (ICS) reduce exacerbation rates and the decline in lung function in people with chronic obstructive pulmonary disease (COPD). There is evidence that smoking causes ‘steroid resistance’ and thus reduces the effect o... Read More about Impact of smoking status on the efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review.

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Cipriani, A., …Hippisley-Cox, J. (2019). Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22(3), 129-133. https://doi.org/10.1136/ebmental-2019-300097

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.

Prescription opioids: regional variation and socioeconomic status: evidence from primary care in England (2019)
Journal Article
Chen, T., Chen, L., Kerry, M., & Knaggs, R. D. (2019). Prescription opioids: regional variation and socioeconomic status: evidence from primary care in England. International Journal of Drug Policy, 64, 87-94. https://doi.org/10.1016/j.drugpo.2018.10.013

Background: This study aimed to quantify dispensed opioid prescriptions among primary care practices throughout England and investigate its association with socioeconomic status (SES). Methods: This cross-sectional study used publicly available data... Read More about Prescription opioids: regional variation and socioeconomic status: evidence from primary care in England.

Interventions for the reduction of prescribed opioid use in chronic non-cancer pain (2017)
Journal Article
Eccleston, C., Fisher, E., Thomas, K. H., Hearn, L., Derry, S., Stannard, C., …Moore, R. A. (in press). Interventions for the reduction of prescribed opioid use in chronic non-cancer pain. Cochrane Database of Systematic Reviews, 11, Article CD010323. https://doi.org/10.1002/14651858.CD010323.pub3

Background This is the first update of the original Cochrane Review published in 2013. The conclusions of this review have not changed from the 2013 publication. People with chronic non-cancer pain who are prescribed and are taking opioids can hav... Read More about Interventions for the reduction of prescribed opioid use in chronic non-cancer pain.

A 15-year overview of increasing tramadol utilisation and associated mortality and the impact of tramadol classification in the United Kingdom (2017)
Journal Article
Chen, T., Chen, L., & Knaggs, R. D. (2018). A 15-year overview of increasing tramadol utilisation and associated mortality and the impact of tramadol classification in the United Kingdom. Pharmacoepidemiology and Drug Safety, 27(5), 487-494. https://doi.org/10.1002/pds.4320

Purpose This study aimed to develop hypotheses to explain the increasing tramadol utilisation, evaluate the impact of tramadol classification, and explore the trend between tramadol utilisation and related deaths in the United Kingdom. Methods... Read More about A 15-year overview of increasing tramadol utilisation and associated mortality and the impact of tramadol classification in the United Kingdom.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., …Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis (2017)
Journal Article
Janknegt, R., van den Beuken, M., Schiere, S., Überall, M., Knaggs, R., Hanley, J., & Thronaes, M. (in press). Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis. European Journal of Hospital Pharmacy, 25(3), https://doi.org/10.1136/ejhpharm-2016-001127

Drug selection of rapid acting fentanyl formulations in the treatment of breakthrough pain in patients with cancer is performed by the System of Objectified Judgement Analysis method. All seven available formulations were included in the analysis. Th... Read More about Rapid acting fentanyl formulations in breakthrough pain in cancer: drug selection by means of the System of Objectified Judgement Analysis.

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults (2016)
Journal Article
Wiffen, P. J., Knaggs, R., Derry, S., Cole, P., Phillips, T., & Moore, R. A. (2016). Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD012227. https://doi.org/10.1002/14651858.CD012227.pub2

BACKGROUND Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies. OBJECTIVES To... Read More about Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.

Hydromorphone for cancer pain (2016)
Journal Article
Bao, Y. J., Hou, W., Kong, X. Y., Yang, L., Xia, J., Hua, B. J., & Knaggs, R. (2016). Hydromorphone for cancer pain. Cochrane Database of Systematic Reviews, Article CD011108. https://doi.org/10.1002/14651858.CD011108.pub2

BACKGROUND Cancer pain is an important and distressing symptom that tends to increase in frequency and intensity as the cancer advances. For people with advanced cancer, the prevalence of pain can be as high as 90%. It has been estimated that 30%... Read More about Hydromorphone for cancer pain.

Fentanyl for neuropathic pain in adults (2016)
Journal Article
Derry, S., Stannard, C., Cole, P., Wiffen, P. J., Knaggs, R., Aldington, D., & Moore, R. A. (2016). Fentanyl for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD011605. https://doi.org/10.1002/14651858.CD011605.pub2

BACKGROUND Opioid drugs, including fentanyl, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for fentanyl, a... Read More about Fentanyl for neuropathic pain in adults.

Is tapentadol different from classical opioids?: a review of the evidence (2016)
Journal Article
Langford, R. M., Knaggs, R., Farquhar-Smith, P., & Dickenson, A. H. (2016). Is tapentadol different from classical opioids?: a review of the evidence. British Journal of Pain, 10(4), https://doi.org/10.1177/2049463716657363

Tapentadol is a single molecule able to deliver analgesia by two distinct mechanisms, a feature which differentiates it from many other analgesics. Pre-clinical data demonstrate two mechanisms of action: mu-opioid receptor agonist activity and noradr... Read More about Is tapentadol different from classical opioids?: a review of the evidence.

Hydromorphone for neuropathic pain in adults (2016)
Journal Article
Stannard, C., Gaskell, H., Derry, S., Aldington, D., Cole, P., Cooper, T. E., …Moore, R. A. (2016). Hydromorphone for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD011604. https://doi.org/10.1002/14651858.CD011604.pub2

BACKGROUND Opioid drugs, including hydromorphone, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for hydrom... Read More about Hydromorphone for neuropathic pain in adults.

Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol (2016)
Journal Article
AlAujan, S., AlMazrou, S., Knaggs, R. D., & Elliott, R. A. (2016). Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol. Journal of Multidisciplinary Healthcare, 9, https://doi.org/10.2147/JMDH.S97904

BACKGROUND Low back pain (LBP) and fibromyalgia (FM), also known as chronic widespread pain (CWP), are highly prevalent chronic painful conditions that have substantial impact on patients, health care systems, and society. Diagnosis is complex and... Read More about Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol.

Buprenorphine for neuropathic pain in adults (2015)
Journal Article
Wiffen, P. J., Derry, S., Moore, R. A., Stannard, C., Aldington, D., Cole, P., & Knaggs, R. (2015). Buprenorphine for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD011603. https://doi.org/10.1002/14651858.CD011603.pub2

BACKGROUND Opioid drugs, including buprenorphine, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for bupren... Read More about Buprenorphine for neuropathic pain in adults.

Acupuncture or low frequency infrared treatment for low back pain in Chinese patients: a discrete choice experiment (2015)
Journal Article
Chen, L., Cheng, L., Zhang, Y., He, Z., & Knaggs, R. (2015). Acupuncture or low frequency infrared treatment for low back pain in Chinese patients: a discrete choice experiment. PLoS ONE, 10(5), Article e0126912. https://doi.org/10.1371/journal.pone.0126912

Acupuncture is a popular but controversial treatment option for low back pain. In China, it is practised as traditional Chinese medicine; other treatment strategies for low back pain are commonly practised as Western medicine. Research on patient pre... Read More about Acupuncture or low frequency infrared treatment for low back pain in Chinese patients: a discrete choice experiment.