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Professor KIM THOMAS's Outputs (141)

How should minimally important change (MIC) scores for the Patient Oriented Eczema Measure (POEM) be interpreted?: a validation using varied methods (2018)
Journal Article
Howells, L., Ratib, S., Chalmers, J., Bradshaw, L., & Thomas, K. (2018). How should minimally important change (MIC) scores for the Patient Oriented Eczema Measure (POEM) be interpreted?: a validation using varied methods. British Journal of Dermatology, 178(5), https://doi.org/10.1111/bjd.16367

Background

The Patient Oriented Eczema Measure (POEM), scored 0-28, is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To date, two published studies have broadly concurred that the... Read More about How should minimally important change (MIC) scores for the Patient Oriented Eczema Measure (POEM) be interpreted?: a validation using varied methods.

Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts (2018)
Journal Article
Teasdale, E., Muller, I., Abdullah Sani, A., Thomas, K. S., Stuart, B., & Santer, M. (2018). Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. BMJ Open, 8(1), 1-7. https://doi.org/10.1136/bmjopen-2017-018652

Objectives: Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access inform... Read More about Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts.

What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology (2018)
Journal Article
Davies, E., Rogers, N. K., Lloyd-Lavery, A., Grindlay, D. J. C., & Thomas, K. S. (2018). What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology. Clinical and Experimental Dermatology, 43(4), 375-379. https://doi.org/10.1111/ced.13377

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 15 systematic reviews that were published... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology.

Which outcomes are reported in cellulitis trials?: results of a review of outcomes included in cellulitis trials and a patient priority setting survey (2017)
Journal Article
Smith, E., Patel, M., & Thomas, K. (2018). Which outcomes are reported in cellulitis trials?: results of a review of outcomes included in cellulitis trials and a patient priority setting survey. British Journal of Dermatology, 178(5), 1028-1034. https://doi.org/10.1111/bjd.16235

Background

There is an emerging need to develop consistent outcomes in clinical trials to allow effective comparison of treatment effects. No systematic review has previously looked at the reporting of outcome measures used in randomised controlle... Read More about Which outcomes are reported in cellulitis trials?: results of a review of outcomes included in cellulitis trials and a patient priority setting survey.

'When it goes back to my normal I suppose': A qualitative study using online focus groups to explore perceptions of 'control' among people with eczema and parents of children with eczema in the UK (2017)
Journal Article
Howells, L. M., Chalmers, J. R., Cowdell, F., Ratib, S., Santer, M., & Thomas, K. S. (2017). 'When it goes back to my normal I suppose': A qualitative study using online focus groups to explore perceptions of 'control' among people with eczema and parents of children with eczema in the UK. BMJ Open, 7, e017731. https://doi.org/10.1136/bmjopen-2017-017731

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Objective: To inform the development of a core outcome set... Read More about 'When it goes back to my normal I suppose': A qualitative study using online focus groups to explore perceptions of 'control' among people with eczema and parents of children with eczema in the UK.

A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria (2017)
Journal Article
Burden-Teh, E., Phillips, R., Thomas, K., Ratib, S., Grindlay, D., & Murphy, R. (2018). A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria. British Journal of Dermatology, 178(5), 1035-1043. https://doi.org/10.1111/bjd.16104

Background: The diagnosis of psoriasis in adults and children is made clinically, for both patient management and the selection of participants in research. Diagnostic criteria provide a structure for clinical assessment, which in turn helps standard... Read More about A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria.

The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHES randomised controlled trial (2017)
Journal Article
Wake, E., Batchelor, J. M., Lawton, S., Thomas, K., Harrison, E. F., & Cowdell, F. (2018). The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHES randomised controlled trial. British Journal of Dermatology, 178(1), 183-190. https://doi.org/10.1111/bjd.15909

Background: Many children suffer with skin diseases, but to date, most dermatological research has been done ‘on’ rather than ‘with’ children; in this study we actively sought the experiences of children and young people. Atopic eczema (AE) is a chro... Read More about The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHES randomised controlled trial.

Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial (2017)
Journal Article
Chalmers, J. R., Haines, R. H., Mitchell, E. J., Thomas, K. S., Brown, S. J., Ridd, M., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Bradshaw, L. E., Montgomery, A. A., Boyle, R. J., & Williams, H. C. (2017). Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial. Trials, 18(1), Article 343. https://doi.org/10.1186/s13063-017-2031-3

Background: Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a significant cost burden for... Read More about Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial.

Identifying priority areas for research into the diagnosis, treatment and prevention of cellulitis (erysipelas): results of a James Lind Alliance Priority Setting Partnership (2017)
Journal Article
Thomas, K., Brindle, R., Chalmers, J., Gamble, B., Francis, N., Hardy, D., Hooper, J., Keeley, V., Levell, N., McPhee, M., Metcalfe, L., Santer, M., Tarpey, M., Smart, P., Wallace, A., & Wilkes, S. (in press). Identifying priority areas for research into the diagnosis, treatment and prevention of cellulitis (erysipelas): results of a James Lind Alliance Priority Setting Partnership. British Journal of Dermatology, 177(2), https://doi.org/10.1111/bjd.15634

Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial (2017)
Journal Article
Mason, J., Thomas, K., Ormerod, A., Craig, F., Mitchell, E., Norrie, J., & Williams, H. (2017). Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial. British Journal of Dermatology, 177(6), 1527-1536. https://doi.org/10.1111/bjd.15561

Background

Pyoderma gangrenosum (PG) is a painful, ulcerating skin disease with poor evidence for management. Prednisolone and ciclosporin are the most commonly used treatments, although not previously compared within a randomised controlled trial... Read More about Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial.

Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review (2017)
Journal Article
Prayle, A., Cox, T., Smith, S., Rycroft-Malone, J., Thomas, K. S., Hughes, D. A., & Smyth, A. R. (in press). Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review. Thorax, https://doi.org/10.1136/thoraxjnl-2016-208790

Cochrane Reviews summarise best evidence and should inform guidelines. We assessed the use of Cochrane Reviews in the UK guidelines for paediatric respiratory disease. We found 21 guidelines which made 1025 recommendations, of which 96 could be infor... Read More about Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review.

Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks (2017)
Journal Article
Langan, S. M., Stuart, B., Bradshaw, L., Schmitt, J., Williams, H. C., & Thomas, K. S. (2017). Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks. Journal of Allergy and Clinical Immunology, 140(6), 1580-1586. https://doi.org/10.1016/j.jaci.2017.02.043

Background:Because atopic dermatitis (AD) is a relapsing, remitting disease, assessing long‐term control is important. Well controlled weeks (WCWs) have been used to assess asthma long‐term control, but never validated for AD.
Objectives: To assess... Read More about Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks.

Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial) (2017)
Journal Article
Thomas, K. S., Bradshaw, L. E., Sach, T. H., Batchelor, J. M., Lawton, S., Harrison, E. F., Haines, R. H., Ahmed, A., Williams, H. C., Dean, T., Burrows, N. P., Pollock, I., Duley, L., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Mitchell, E. J., Cowdell, F., …MacCallum, S. (2017). Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). PLoS Medicine, 14(4), Article e1002280. https://doi.org/10.1371/journal.pmed.1002280

© 2017 Thomas et al. Background: The role of clothing in the management of eczema (also called atopic dermatitis or atopic eczema) is poorly understood. This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to st... Read More about Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial).

Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial (2017)
Journal Article
Thomas, K. S., Bradshaw, L., Sach, T. H., Cowdell, F., Batchelor, J. M., Lawton, S., Harrison, E. F., Haines, R. H., Ahmed, A., Dean, T., Burrows, N. P., Pollock, I., Buckley, H., Williams, H. C., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Wake, E., …Montgomery, A. A. (2017). Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial. Health Technology Assessment, 21(16), https://doi.org/10.3310/hta21160

Background: Atopic eczema (AE) is a chronic, itchy, inflammatory skin condition that affects the quality of life of children and their families. The role of specialist clothing in the management of AE is poorly understood.
Objectives: To assess the... Read More about Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial.

Investigating the effect of independent blinded digital image assessment on the STOP GAP trial (2017)
Journal Article
Patsko, E., Godolphin, P. J., Thomas, K. S., Hepburn, T., Mitchell, E., Craig, F. E., Bath, P. M., & Montgomery, A. A. (2017). Investigating the effect of independent blinded digital image assessment on the STOP GAP trial. Trials, 18(1), Article 53. https://doi.org/10.1186/s13063-017-1779-9

Background
Blinding is the process of keeping treatment assignment hidden and is used to minimise the possibility of bias. Trials at high risk of bias have been shown to report larger treatment effects than low risk studies. In dermatology, one popu... Read More about Investigating the effect of independent blinded digital image assessment on the STOP GAP trial.

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease (2016)
Journal Article
Thomas, K. S., Batchelor, J. M., Bath-Hextall, F., Chalmers, J., Clarke, T., Crowe, S., Delamere, F. M., Eleftheriadou, V., Evans, N., Firkins, L., Greenlaw, N., Lansbury, L. E., Lawton, S., Layfield, C., Leonardi-Bee, J., Mason, J., Mitchell, E., Nankervis, H., Norrie, J., Nunn, A., …Williams, H. C. (2016). A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease. Programme Grants for Applied Research, 4(18), https://doi.org/10.3310/pgfar04180

Background

Skin diseases are very common and can have a large impact on the quality of life of patients and caregivers. This programme addressed four diseases: (1) eczema, (2) vitiligo, (3) squamous cell skin cancer (SCC) and (4) pyoderma gangreno... Read More about A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease.

What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention (2016)
Journal Article
Lloyd-Lavery, A., Rogers, N. K., Hatfield, S. J., Grindlay, D., Barnett, R., & Thomas, K. S. (2017). What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention. Clinical and Experimental Dermatology, 42(1), 3-7. https://doi.org/10.1111/ced.12967

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE). It provides a summary of key findings from 12 systematic reviews (SRs) that were published or indexed during 2014, and focuses on the treatm... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention.

Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement (2016)
Journal Article
Spuls, P., Gerbens, L., Simpson, E., Apfelbacher, C., Chalmers, J., Thomas, K., Prinsen, C., Kobyletzki, L. V., Singh, J., Williams, H. C., & Schmitt, J. (2017). Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement. British Journal of Dermatology, 176(4), 979-984. https://doi.org/10.1111/bjd.15179

Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, q... Read More about Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement.

What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes (2016)
Journal Article
Hatfield, S. J., Rogers, N. K., Lloyd-Lavery, A., Grindlay, D., Barnett, R., & Thomas, K. S. (2016). What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes. Clinical and Experimental Dermatology, 41(8), 843-846. https://doi.org/10.1111/ced.12977

This review summarizes key findings from nine systematic reviews on atopic eczema (AE) published or first indexed in 2014. It focuses on epidemiology, disease processes and methodological issues. There is reasonable evidence to conclude that high bir... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes.